3SS1
| Clostridium difficile toxin A (TcdA) glucolsyltransferase domain | Descriptor: | MANGANESE (II) ION, Toxin A | Authors: | Pruitt, R.N, Chumbler, N.M, Farrow, M.A, Seeback, S.A, Friedman, D.B, Spiller, B.W, Lacy, D.B. | Deposit date: | 2011-07-07 | Release date: | 2012-02-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity. J.Biol.Chem., 287, 2012
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4DMW
| Crystal structure of the GT domain of Clostridium difficile toxin A (TcdA) in complex with UDP and Manganese | Descriptor: | MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE | Authors: | Malito, E, D'Urzo, N, Bottomley, M.J, Biancucci, M, Scarselli, M, Maione, D, Martinelli, M. | Deposit date: | 2012-02-08 | Release date: | 2012-07-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release. Febs J., 279, 2012
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4DMV
| Crystal structure of the GT domain of Clostridium difficile Toxin A | Descriptor: | Toxin A | Authors: | Malito, E, D'Urzo, N, Bottomley, M.J, Biancucci, M, Maione, D, Scarselli, M, Martinelli, M. | Deposit date: | 2012-02-08 | Release date: | 2012-07-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release. Febs J., 279, 2012
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2BVL
| Crystal structure of the catalytic domain of toxin B from Clostridium difficile in complex with UDP, Glc and manganese ion | Descriptor: | HEXATANTALUM DODECABROMIDE, MANGANESE (II) ION, SULFATE ION, ... | Authors: | Reinert, D.J, Jank, T, Aktories, K, Schulz, G.E. | Deposit date: | 2005-06-30 | Release date: | 2005-08-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis for the Function of Clostridium Difficile Toxin B. J.Mol.Biol., 351, 2005
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2BVM
| Crystal structure of the catalytic domain of toxin B from Clostridium difficile in complex with UDP, Glc and manganese ion | Descriptor: | MANGANESE (II) ION, SULFATE ION, TOXIN B, ... | Authors: | Reinert, D.J, Jank, T, Aktories, K, Schulz, G.E. | Deposit date: | 2005-06-30 | Release date: | 2005-08-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural Basis for the Function of Clostridium Difficile Toxin B. J.Mol.Biol., 351, 2005
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3SRZ
| Clostridium difficile toxin A (TcdA) glucolsyltransferase domain bound to UDP-glucose | Descriptor: | MANGANESE (II) ION, Toxin A, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Pruitt, R.N, Chumbler, N.M, Farrow, M.A, Seeback, S.A, Friedman, D.B, Spiller, B.W, Lacy, D.B. | Deposit date: | 2011-07-07 | Release date: | 2012-02-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity. J.Biol.Chem., 287, 2012
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6OQ8
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2VK9
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9BON
| Crystal structure of glucosyltransferase (GTD) domain of TpeL | Descriptor: | TpeL | Authors: | Gill, S, Sugiman-Marangos, S.N, Beilhartz, G.L, Mei, E, Taipale, M, Melnyk, R.A. | Deposit date: | 2024-05-05 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.222 Å) | Cite: | A diphtheria toxin-like intracellular delivery platform that evades pre-existing antidrug antibodies. Embo Mol Med, 2024
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7SO7
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7SO5
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5UQK
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5UQN
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5UQL
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5UQT
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7UBY
| Structure of the GTD domain of Clostridium difficile toxin A in complex with VHH AH3 | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Glucosyltransferase TcdA, ... | Authors: | Chen, B, Rongsheng, J, Kay, P. | Deposit date: | 2022-03-15 | Release date: | 2022-11-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies. Front Immunol, 13, 2022
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5UQM
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7LOU
| Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and isofagomine | Descriptor: | 1,2-ETHANEDIOL, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, Glucosyltransferase TcdB, ... | Authors: | Harijan, R.K, Paparella, A.S, Aboulache, B.L, Bonanno, J.B, Almo, S.C, Schramm, V.L. | Deposit date: | 2021-02-10 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues. Nat Commun, 12, 2021
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7LOV
| Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and noeuromycin | Descriptor: | (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Harijan, R.K, Paparella, A.S, Aboulache, B.L, Bonanno, J.B, Almo, S.C, Schramm, V.L. | Deposit date: | 2021-02-10 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues. Nat Commun, 12, 2021
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7POG
| High-resolution structure of native toxin A from Clostridioides difficile | Descriptor: | Toxin A, ZINC ION | Authors: | Boesen, T, Joergensen, R, Aminzadeh, A, Engelbrecht Larsen, C. | Deposit date: | 2021-09-08 | Release date: | 2021-12-08 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | High-resolution structure of native toxin A from Clostridioides difficile. Embo Rep., 23, 2022
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8JHZ
| Cryo-EM structure of the TcsH-TMPRSS2 complex | Descriptor: | Hemorrhagic toxin, Transmembrane protease serine 2, ZINC ION | Authors: | Zhou, R, Liang, T, Zhan, X. | Deposit date: | 2023-05-25 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin. Nat Commun, 15, 2024
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4R04
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8JB5
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6AR6
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7S0Y
| Structures of TcdB in complex with Cdc42 | Descriptor: | Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Zheng, L, Rongsheng, J, Peng, C. | Deposit date: | 2021-08-31 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B. Sci Adv, 7, 2021
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