2BVL
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF TOXIN B FROM CLOSTRIDIUM DIFFICILE IN COMPLEX WITH UDP, GLC AND MANGANESE ION
Descriptor:TOXIN B, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Reinert, D.J., Jank, T., Aktories, K., Schulz, G.E.
Deposit date:2005-06-30
Release date:2005-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
2BVM
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF TOXIN B FROM CLOSTRIDIUM DIFFICILE IN COMPLEX WITH UDP, GLC AND MANGANESE ION
Descriptor:TOXIN B, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
Authors:Reinert, D.J., Jank, T., Aktories, K., Schulz, G.E.
Deposit date:2005-06-30
Release date:2005-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
2VK9
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF ALPHA-TOXIN FROM CLOSTRIDIUM NOVYI
Descriptor:ALPHA-TOXIN
Authors:Ziegler, M.O.P., Jank, T., Aktories, K., Schulz, G.E.
Deposit date:2007-12-18
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Conformational Changes and Reaction of Clostridial Glycosylating Toxins.
J.Mol.Biol., 377, 2008
2VKD
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND MANGANESE ION
Descriptor:CYTOTOXIN L, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Ziegler, M.O.P., Jank, T., Aktories, K., Schulz, G.E.
Deposit date:2007-12-18
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Conformational Changes and Reaction of Clostridial Glycosylating Toxins.
J.Mol.Biol., 377, 2008
2VKH
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND CALCIUM ION
Descriptor:CYTOTOXIN L, CALCIUM ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Ziegler, M.O.P., Jank, T., Aktories, K., Schulz, G.E.
Deposit date:2007-12-19
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational Changes and Reaction of Clostridial Glycosylating Toxins.
J.Mol.Biol., 377, 2008
2VL8
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION
Descriptor:CYTOTOXIN L, URIDINE-5'-DIPHOSPHATE, CASTANOSPERMINE, ...
Authors:Jank, T., Ziegler, M.O.P., Schulz, G.E., Aktories, K.
Deposit date:2008-01-09
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Inhibition of the Glucosyltransferase Activity of Clostridial Rho/Ras-Glucosylating Toxins by Castanospermine.
FEBS Lett., 582, 2008
3SRZ
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CLOSTRIDIUM DIFFICILE TOXIN A (TCDA) GLUCOLSYLTRANSFERASE DOMAIN BOUND TO UDP-GLUCOSE
Descriptor:Toxin A, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Pruitt, R.N., Chumbler, N.M., Farrow, M.A., Seeback, S.A., Friedman, D.B., Spiller, B.W., Lacy, D.B.
Deposit date:2011-07-07
Release date:2012-02-01
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
3SS1
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CLOSTRIDIUM DIFFICILE TOXIN A (TCDA) GLUCOLSYLTRANSFERASE DOMAIN
Descriptor:Toxin A, MANGANESE (II) ION
Authors:Pruitt, R.N., Chumbler, N.M., Farrow, M.A., Seeback, S.A., Friedman, D.B., Spiller, B.W., Lacy, D.B.
Deposit date:2011-07-07
Release date:2012-02-01
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
4DMV
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CRYSTAL STRUCTURE OF THE GT DOMAIN OF CLOSTRIDIUM DIFFICILE TOXIN A
Descriptor:Toxin A
Authors:Malito, E., D'Urzo, N., Bottomley, M.J., Biancucci, M., Maione, D., Scarselli, M., Martinelli, M.
Deposit date:2012-02-08
Release date:2012-07-18
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release.
Febs J., 279, 2012
4DMW
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CRYSTAL STRUCTURE OF THE GT DOMAIN OF CLOSTRIDIUM DIFFICILE TOXIN A (TCDA) IN COMPLEX WITH UDP AND MANGANESE
Descriptor:Toxin A, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE
Authors:Malito, E., D'Urzo, N., Bottomley, M.J., Biancucci, M., Scarselli, M., Maione, D., Martinelli, M.
Deposit date:2012-02-08
Release date:2012-07-18
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release.
Febs J., 279, 2012
5UQK
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CLOSTRIDIUM DIFFICILE TOXIN A (TCDA) GLUCOSYLTRANSFERASE DOMAIN IN COMPLEX WITH U2F
Descriptor:Toxin A, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE, MANGANESE (II) ION
Authors:Alvin, J.W., Lacy, D.B.
Deposit date:2017-02-08
Release date:2017-05-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQL
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CLOSTRIDIUM DIFFICILE TOXIN A (TCDA) GLUCOSYLTRANSFERASE DOMAIN IN COMPLEX WITH U2F
Descriptor:Toxin A, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE
Authors:Alvin, J.W., Lacy, D.B.
Deposit date:2017-02-08
Release date:2017-05-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQM
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CLOSTRIDIUM DIFFICILE TOXIN B (TCDB) GLUCOSYLTRANSFERASE DOMAIN IN COMPLEX WITH U2F
Descriptor:Toxin B, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE, ...
Authors:Alvin, J.W., Lacy, D.B.
Deposit date:2017-02-08
Release date:2017-05-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQN
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CLOSTRIDIUM DIFFICILE TOXIN B (TCDB) GLUCOSYLTRANSFERASE DOMAIN IN COMPLEX WITH U2F
Descriptor:Toxin B, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE, ...
Authors:Alvin, J.W., Lacy, D.B.
Deposit date:2017-02-08
Release date:2017-05-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQT
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CLOSTRIDIUM DIFFICILE TOXIN B (TCDB) GLUCOSYLTRANSFERASE DOMAIN CO-CRYSTALLIZED WITH APIGENIN
Descriptor:Toxin B, MANGANESE (II) ION, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Authors:Alvin, J.W., Lacy, D.B.
Deposit date:2017-02-08
Release date:2017-05-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5VQM
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CLOSTRIDIUM DIFFICILE TCDB-GTD BOUND TO PA41 FAB
Descriptor:Toxin B, PA41 FAB LIGHT CHAIN, PA41 FAB HEAVY CHAIN
Authors:Kroh, H.K., Spiller, B.W., Lacy, D.B.
Deposit date:2017-05-09
Release date:2017-12-06
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.
J. Biol. Chem., 293, 2018
4R04
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CLOSTRIDIUM DIFFICILE TOXIN A (TCDA)
Descriptor:Toxin A, ZINC ION
Authors:Lacy, D.B., Spiller, B.W., Rutherford, S.A.
Deposit date:2014-07-29
Release date:2016-01-06
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Glucosyl Transferase Structure
Nat Microbiol, 2016
6AR6
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CLOSTRIDIOIDES DIFFICILE TOXINB WITH DLD-4 DARPIN
Descriptor:Toxin B, DLD-4 darpin
Authors:Zhang, J., Jiang, M.
Deposit date:2017-08-21
Release date:2018-08-22
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Clostridioides difficile toxinB with DLD-4 darpin
To Be Published
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