1L0O
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CRYSTAL STRUCTURE OF THE BACILLUS STEAROTHERMOPHILUS ANTI-SIGMA FACTOR SPOIIAB WITH THE SPORULATION SIGMA FACTOR SIGMAF
Descriptor:Anti-sigma F factor, sigma factor, MAGNESIUM ION, ...
Authors:Campbell, E.A., Masuda, S., Sun, J.L., Muzzin, O., Olson, C.A., Wang, S., Darst, S.A.
Deposit date:2002-02-12
Release date:2002-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the Bacillus stearothermophilus anti-sigma factor SpoIIAB with the sporulation sigma factor sigmaF.
Cell(Cambridge,Mass.), 108, 2002
1RP3
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COCRYSTAL STRUCTURE OF THE FLAGELLAR SIGMA/ANTI-SIGMA COMPLEX, SIGMA-28/FLGM
Descriptor:RNA polymerase sigma factor SIGMA-28 (FliA), anti sigma factor FlgM
Authors:Sorenson, M.K., Ray, S.S., Darst, S.A.
Deposit date:2003-12-02
Release date:2004-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Flagellar Sigma/Anti-Sigma Complex Sigma(28)/FlgM Reveals an Intact Sigma Factor in an Inactive Conformation
Mol.Cell, 14, 2004
1SC5
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SIGMA-28(FLIA)/FLGM COMPLEX
Descriptor:RNA polymerase sigma factor FliA, anti-sigma factor FlgM
Authors:Sorenson, M.K., Ray, S.S., Darst, S.A.
Deposit date:2004-02-11
Release date:2004-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation.
Mol.Cell, 14, 2004
1IW7
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CRYSTAL STRUCTURE OF THE RNA POLYMERASE HOLOENZYME FROM THERMUS THERMOPHILUS AT 2.6A RESOLUTION
Descriptor:RNA polymerase alpha subunit, RNA polymerase beta subunit, RNA polymerase omega subunit, ...
Authors:RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-04-22
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution
NATURE, 417, 2002
1L9U
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THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME AT 4 A RESOLUTION
Descriptor:RNA POLYMERASE, ALPHA SUBUNIT, BETA SUBUNIT, ...
Authors:Murakami, K.S., Masuda, S., Darst, S.A.
Deposit date:2002-03-26
Release date:2002-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution.
Science, 296, 2002
1L9Z
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THERMUS AQUATICUS RNA POLYMERASE HOLOENZYME/FORK-JUNCTION PROMOTER DNA COMPLEX AT 6.5 A RESOLUTION
Descriptor:nontemplate DNA strand, template DNA strand, RNA POLYMERASE, ...
Authors:Murakami, K.S., Masuda, S., Campbell, E.A., Muzzin, O., Darst, S.A.
Deposit date:2002-03-27
Release date:2002-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (6.5 Å)
Cite:Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex.
Science, 296, 2002
1SMY
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STRUCTURAL BASIS FOR TRANSCRIPTION REGULATION BY ALARMONE PPGPP
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Artsimovitch, I., Patlan, V., Sekine, S., Vassylyeva, M.N., Hosaka, T., Ochi, K., Yokoyama, S., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-03-10
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for transcription regulation by alarmone ppGpp
Cell(Cambridge,Mass.), 117, 2004
1ZYR
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STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC STREPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase subunit beta' chain, ...
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2A68
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFABUTIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-01
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A69
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC RIFAPENTIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6E
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6H
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC STERPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Temiakov, D., Zenkin, N., Vassylyeva, M.N., Perederina, A., Tahirov, T.H., Savkina, M., Zorov, S., Nikiforov, V., Igarashi, N., Matsugaki, N., Wakatsuki, S., Severinov, K., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
2BE5
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH INHIBITOR TAGETITOXIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Vassylyev, D.G., Svetlov, V., Vassylyeva, M.N., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Artsimovitch, I., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-10-22
Release date:2005-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for transcription inhibition by tagetitoxin
Nat.Struct.Mol.Biol., 12, 2005
2CW0
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME AT 3.3 ANGSTROMS RESOLUTION
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark Jr., A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
3DXJ
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC MYXOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha; CHAIN A, B, K, ...
Authors:Das, K., Arnold, E.
Deposit date:2008-07-24
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The RNA polymerase "switch region" is a target for inhibitors.
Cell(Cambridge,Mass.), 135, 2008
3EQL
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC MYXOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Vassylyev, D.G., Vassylyeva, M.N., Artsimovitch, I.
Deposit date:2008-09-30
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Transcription inactivation through local refolding of the RNA polymerase structure.
Nature, 457, 2009
3IYD
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THREE-DIMENSIONAL EM STRUCTURE OF AN INTACT ACTIVATOR-DEPENDENT TRANSCRIPTION INITIATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit omega, ...
Authors:Hudson, B.P., Quispe, J., Lara, S., Kim, Y., Berman, H., Arnold, E., Ebright, R.H., Lawson, C.L.
Deposit date:2009-08-01
Release date:2009-11-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (19.799999 Å)
Cite:Three-dimensional EM structure of an intact activator-dependent transcription initiation complex
Proc.Natl.Acad.Sci.USA, 106, 2009
3WOD
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RNA POLYMERASE-GP39 COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Tagami, S., Sekine, S., Minakhin, L., Esyunina, D., Akasaka, R., Shirouzu, M., Kulbachinskiy, A., Severinov, K., Yokoyama, S.
Deposit date:2013-12-26
Release date:2014-03-12
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes Dev., 28, 2014
4G7H
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7O
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX CONTAINING 2 NT OF RNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.993 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7Z
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX CONTAINING 5-BRU AT TEMPLATE-STRAND POSITION +1
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.815 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4JK1
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X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMA70 HOLOENZYME IN COMPLEX WITH GUANOSINE TETRAPHOSPHATE (PPGPP)
Descriptor:Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-10
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JK2
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X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI SIGMA70 HOLOENZYME IN COMPLEX WITH GUANOSINE PENTAPHOSPHATE (PPPGPP)
Descriptor:Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ...
Authors:Murakami, K.S.
Deposit date:2013-03-09
Release date:2013-04-17
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (4.201 Å)
Cite:Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res., 41, 2013
4JKR
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CRYSTAL STRUCTURE OF E. COLI RNA POLYMERASE IN COMPLEX WITH PPGPP
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', ...
Authors:Zuo, Y., Wang, Y., Steitz, T.A.
Deposit date:2013-03-11
Release date:2013-05-15
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.
Mol.Cell, 50, 2013
4KMU
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X-RAY CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI RNA POLYMERASE IN COMPLEX WITH RIFAMPIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
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