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4HAT	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
7CND	NCI-1 in complex with CRM1-Ran-RanBP1 Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-07-31 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1. J.Med.Chem., 64, 2021
4HB2	Crystal structure of CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAW	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548A)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAZ	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(R543S,K548E,K579Q)-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
6XJR	Crystal Structure of KPT-185 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) Descriptor: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... Authors: Baumhardt, J.M, Chook, Y.M. Deposit date: 2020-06-24 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.941 Å) Cite: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
6XJS	Crystal Structure of KPT-330 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M, Chook, Y.M. Deposit date: 2020-06-24 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.942 Å) Cite: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
7L5E	Crystal Structure of KPT-330 bound to CRM1 (537-DLTVK-541 to GLCEQ) Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M, Chook, Y.M. Deposit date: 2020-12-21 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.944 Å) Cite: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
3M1I	Crystal structure of yeast CRM1 (Xpo1p) in complex with yeast RanBP1 (Yrb1p) and yeast RanGTP (Gsp1pGTP) Descriptor: Exportin-1, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Koyama, M, Matsuura, Y. Deposit date: 2010-03-05 Release date: 2010-06-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1 Embo J., 29, 2010
5OWU	Kap95:Nup1 complex Descriptor: Importin subunit beta-1, Nucleoporin NUP1 Authors: Stewart, M. Deposit date: 2017-09-04 Release date: 2017-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p. J. Mol. Biol., 349, 2005
4HAV	Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1 Descriptor: Anguinomycin A, bound form, CHLORIDE ION, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HAU	Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
1WA5	Structure of the Cse1:Imp-alpha:RanGTP complex Descriptor: GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin alpha re-exporter, ... Authors: Stewart, M. Deposit date: 2004-10-23 Release date: 2004-12-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for the assembly of a nuclear export complex. Nature, 432, 2004
6CIT	Crystal Structure of MVM NS2 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2018-02-25 Release date: 2018-06-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.027 Å) Cite: Correlation of CRM1-NES affinity with nuclear export activity. Mol. Biol. Cell, 29, 2018
8HQ6	KL2 in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Jian, L. Deposit date: 2022-12-13 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
5YST	RanM189D in complex with RanBP1-CRM1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1,Exportin-1, ... Authors: Sun, Q, Zhang, Y. Deposit date: 2017-11-15 Release date: 2018-11-21 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.04 Å) Cite: RanM189D in complex with RanBP1-CRM1 To Be Published
4XRI	Crystal Structure of Importin Beta in an Ammonium Sulfate Condition Descriptor: GLYCEROL, Putative uncharacterized protein, SULFATE ION Authors: Tauchert, M.J, Neumann, P, Ficner, R, Dickmanns, A. Deposit date: 2015-01-21 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Impact of the crystallization condition on importin-beta conformation. Acta Crystallogr D Struct Biol, 72, 2016
4HB4	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
5UWP	Crystal Structure of mDia2 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.054 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
7DBG	Yeast CRM1e (apo) in complex with Ran-RanBP1 Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-10-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
5DIF	Crystal Structure of CPEB4 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Cytoplasmic polyadenylation element-binding protein 4, Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.092 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
8HQ3	KL1 in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Jian, L. Deposit date: 2022-12-13 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
4GMX	Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-08-16 Release date: 2012-10-17 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood, 120, 2012
3VYC	Crystal structure of unliganded Saccharomyces cerevisiae CRM1 (Xpo1p) Descriptor: Exportin-1 Authors: Saito, N, Matsuura, Y. Deposit date: 2012-09-22 Release date: 2012-11-28 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A 2.1- angstrom -resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition J.Mol.Biol., 425, 2013
8HQ4	B27 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... Authors: Lei, Y, Sun, Q. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.12 Å) Cite: B27 in complex with CRM1-Ran-RanBP1 To Be Published

 

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