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8CXK
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BU of 8cxk by Molmil
Structure of the C. elegans HIM-3 R93Y mutant
Descriptor: HORMA domain-containing protein
Authors:Ego, K.M, Russo, A, Giacopazzi, S, Deshong, A, Menon, M, Ortiz, V, Bhalla, N, Corbett, K.D.
Deposit date:2022-05-21
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans.
Plos Genet., 19, 2023
6BCD
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BU of 6bcd by Molmil
Crystal structure of Rev7-K44A/R124A/A135D in complex with Rev3-RBM2 (residues 1988-2014)
Descriptor: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Rizzo, A.A, Hao, B, Li, Y, Korzhnev, D.M.
Deposit date:2017-10-20
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Rev7 dimerization is important for assembly and function of the Rev1/Pol zeta translesion synthesis complex.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EKL
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BU of 6ekl by Molmil
Crystal structure of mammalian Rev7 in complex with human Chromosome alignment-maintaining phosphoprotein 1
Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Huber, F, Tropia, L, Emamzadah, S, Halazonetis, T.
Deposit date:2017-09-26
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of mammalian Rev7 in complex with Champ1
To Be Published
6EKJ
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BU of 6ekj by Molmil
Crystal structure of mammalian Rev7 in complex with human Chromosome alignment-maintaining phosphoprotein 1
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Huber, F, Tropia, L, Emamzadah, S, Halazonetis, T.
Deposit date:2017-09-26
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of mammalian Rev7 in complex with Champ1 - CAPS molecule
To Be Published
6BC8
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BU of 6bc8 by Molmil
Crystal structure of Rev7-R124A/Rev3-RBM2 (residues 1988-2014) complex
Descriptor: ACETATE ION, DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B, ...
Authors:Rizzo, A.A, Hao, B, Li, Y, Korzhnev, D.M.
Deposit date:2017-10-20
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Rev7 dimerization is important for assembly and function of the Rev1/Pol zeta translesion synthesis complex.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4TRK
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BU of 4trk by Molmil
Structure of C. elegans HIM-3
Descriptor: C. elegans HIM-3
Authors:Rosenberg, S.C, Corbett, K.D.
Deposit date:2014-06-17
Release date:2014-11-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins.
Dev.Cell, 31, 2014
6M7B
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BU of 6m7b by Molmil
Structure of REV7-R124A complexed with SHLD3(37-73)
Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 3
Authors:Ma, Y.Z, Li, Y, Wu, B.X, Huang, H.D.
Deposit date:2020-03-18
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure of REV7-R124A complexed with SHLD3(37-73)
To Be Published
5O8K
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BU of 5o8k by Molmil
Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895
Descriptor: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Emamzadah, S, Tropia, L, Huber, F, Halazonetis, T.
Deposit date:2017-06-13
Release date:2018-06-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895
To Be Published
4EXT
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BU of 4ext by Molmil
Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta
Descriptor: DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B, peptide from DNA polymerase zeta catalytic subunit
Authors:Liu, D.N, Ryu, K.S, Ko, J.S, Choi, B.S.
Deposit date:2012-05-01
Release date:2013-05-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into the scaffold mechanism of human Rev1 in translesional synthesis revealed by structural studies on its polymerase-interacting domain
To be Published
6M7A
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BU of 6m7a by Molmil
Structure of REV7-R124A complexed with SHLD3(28-73)
Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 3
Authors:Ma, Y.Z, Li, Y, Wu, B.X, Huang, H.D.
Deposit date:2020-03-18
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of REV7-R124A complexed with SHLD3(28-73)
To Be Published
3ABD
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BU of 3abd by Molmil
Structure of human REV7 in complex with a human REV3 fragment in a monoclinic crystal
Descriptor: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Hara, K, Hashimoto, H, Murakumo, Y, Kobayashi, S, Kogame, T, Unzai, S, Akashi, S, Takeda, S, Shimizu, T, Sato, M.
Deposit date:2009-12-07
Release date:2010-02-16
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase {zeta} and REV1
J.Biol.Chem., 285, 2010
2VFX
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BU of 2vfx by Molmil
Structure of the Symmetric Mad2 Dimer
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, CHLORIDE ION, ...
Authors:Yang, M, Li, B, Liu, C.-J, Tomchick, D.R, Machius, M, Rizo, J, Yu, H, Luo, X.
Deposit date:2007-11-05
Release date:2008-03-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer.
Plos Biol., 6, 2008
6VE5
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BU of 6ve5 by Molmil
X-ray structure of human REV7 in complex with Shieldin3 (residues 41-74)
Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2019-12-28
Release date:2021-01-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
6NIF
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BU of 6nif by Molmil
crystal structure of human REV7-RAN complex
Descriptor: hREV7, GTP-binding nuclear protein Ran, hREV3 fusion
Authors:Wang, X, Pertz, L, Hua, D.P, Zhang, T.Q, Listovsky, T, Xie, W.
Deposit date:2018-12-27
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:REV7 has a dynamic adaptor region to accommodate small GTPase RAN/ShigellaIpaB ligands, and its activity is regulated by the RanGTP/GDP switch.
J.Biol.Chem., 294, 2019
1GO4
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BU of 1go4 by Molmil
Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20.
Descriptor: Mitotic spindle assembly checkpoint protein MAD1, Mitotic spindle assembly checkpoint protein MAD2A
Authors:Sironi, L, Mapelli, M, Jeang, K.T, Musacchio, A.
Deposit date:2001-10-17
Release date:2002-05-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.
EMBO J., 21, 2002
5XPT
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BU of 5xpt by Molmil
Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a tetragonal crystal
Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Hara, K, Taharazako, S, Hashimoto, H.
Deposit date:2017-06-05
Release date:2017-09-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).
J. Biol. Chem., 292, 2017
6WS0
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BU of 6ws0 by Molmil
Rational drug design of phenazopyridine derivatives as novel inhibitors of Rev1-CT
Descriptor: DNA polymerase zeta catalytic subunit, DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B
Authors:McPherson, K.S, Korzhnev, D.M.
Deposit date:2020-04-30
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis.
Chemmedchem, 16, 2021
6K07
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BU of 6k07 by Molmil
Crystal structure of REV7(R124A) in complex with a Shieldin3 fragment
Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3
Authors:Zhang, F, Dai, Y.
Deposit date:2019-05-05
Release date:2019-12-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair.
J.Biol.Chem., 295, 2020
4AEZ
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BU of 4aez by Molmil
Crystal Structure of Mitotic Checkpoint Complex
Descriptor: MITOTIC SPINDLE CHECKPOINT COMPONENT MAD2, MITOTIC SPINDLE CHECKPOINT COMPONENT MAD3, WD REPEAT-CONTAINING PROTEIN SLP1
Authors:Kulkarni, K.A, Chao, W.C.H, Zhang, Z, Barford, D.
Deposit date:2012-01-13
Release date:2012-03-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Mitotic Checkpoint Complex
Nature, 484, 2012
4TZQ
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BU of 4tzq by Molmil
Structure of C. elegans HTP-1 bound to HTP-3 motif-1
Descriptor: Protein HTP-1, Protein HTP-3
Authors:Rosenberg, S.C, Corbett, K.D.
Deposit date:2014-07-10
Release date:2014-11-19
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins.
Dev.Cell, 31, 2014
4TZM
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BU of 4tzm by Molmil
C. elegans HTP-2 bound to HTP-3 closure motif 1
Descriptor: C. elegans HTP-3 closure motif1, Protein HTP-2
Authors:Rosenberg, S.C, Corbett, K.D.
Deposit date:2014-07-10
Release date:2014-11-19
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins.
Dev.Cell, 31, 2014
2QYF
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BU of 2qyf by Molmil
Crystal structure of the Mad2/p31(comet)/Mad2-binding peptide ternary complex
Descriptor: MAD2L1-binding protein, Mitotic spindle assembly checkpoint protein MAD2A, peptide
Authors:Tomchick, D.R, Luo, X.
Deposit date:2007-08-14
Release date:2008-01-29
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:p31comet blocks Mad2 activation through structural mimicry.
Cell(Cambridge,Mass.), 131, 2007
5XPU
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BU of 5xpu by Molmil
Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a monoclinic crystal
Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Hara, K, Taharazako, S, Hashimoto, H.
Deposit date:2017-06-05
Release date:2017-09-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).
J. Biol. Chem., 292, 2017
6K08
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BU of 6k08 by Molmil
Crystal structure of REV7(R124A/A135D) in complex with a Shieldin3 fragment
Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3
Authors:Zhang, F, Dai, Y.
Deposit date:2019-05-05
Release date:2019-12-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.312 Å)
Cite:Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair.
J.Biol.Chem., 295, 2020
6KEA
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BU of 6kea by Molmil
crystal structure of MBP-tagged REV7-IpaB complex
Descriptor: Maltose-binding periplasmic protein,LINKER,hREV7,LINKER,Invasin IpaB,hREV3
Authors:Wang, X, Pernicone, N, Pertz, L, Hua, D.P, Zhang, T.Q, Listovsky, T, Xie, W.
Deposit date:2019-07-04
Release date:2019-09-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:REV7 has a dynamic adaptor region to accommodate small GTPase RAN/ShigellaIpaB ligands, and its activity is regulated by the RanGTP/GDP switch.
J.Biol.Chem., 294, 2019

 

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