PDB: 58 resultsInfo pagesStatus searchChemie searchBIRD

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8CXK	Structure of the C. elegans HIM-3 R93Y mutant Descriptor: HORMA domain-containing protein Authors: Ego, K.M, Russo, A, Giacopazzi, S, Deshong, A, Menon, M, Ortiz, V, Bhalla, N, Corbett, K.D. Deposit date: 2022-05-21 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans. Plos Genet., 19, 2023
6BCD	Crystal structure of Rev7-K44A/R124A/A135D in complex with Rev3-RBM2 (residues 1988-2014) Descriptor: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B Authors: Rizzo, A.A, Hao, B, Li, Y, Korzhnev, D.M. Deposit date: 2017-10-20 Release date: 2018-08-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Rev7 dimerization is important for assembly and function of the Rev1/Pol zeta translesion synthesis complex. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EKL	Crystal structure of mammalian Rev7 in complex with human Chromosome alignment-maintaining phosphoprotein 1 Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B Authors: Huber, F, Tropia, L, Emamzadah, S, Halazonetis, T. Deposit date: 2017-09-26 Release date: 2018-10-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of mammalian Rev7 in complex with Champ1 To Be Published
6EKJ	Crystal structure of mammalian Rev7 in complex with human Chromosome alignment-maintaining phosphoprotein 1 Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B Authors: Huber, F, Tropia, L, Emamzadah, S, Halazonetis, T. Deposit date: 2017-09-26 Release date: 2018-10-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of mammalian Rev7 in complex with Champ1 - CAPS molecule To Be Published
6BC8	Crystal structure of Rev7-R124A/Rev3-RBM2 (residues 1988-2014) complex Descriptor: ACETATE ION, DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B, ... Authors: Rizzo, A.A, Hao, B, Li, Y, Korzhnev, D.M. Deposit date: 2017-10-20 Release date: 2018-08-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Rev7 dimerization is important for assembly and function of the Rev1/Pol zeta translesion synthesis complex. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4TRK	Structure of C. elegans HIM-3 Descriptor: C. elegans HIM-3 Authors: Rosenberg, S.C, Corbett, K.D. Deposit date: 2014-06-17 Release date: 2014-11-19 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.751 Å) Cite: The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins. Dev.Cell, 31, 2014
6M7B	Structure of REV7-R124A complexed with SHLD3(37-73) Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 3 Authors: Ma, Y.Z, Li, Y, Wu, B.X, Huang, H.D. Deposit date: 2020-03-18 Release date: 2021-01-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Structure of REV7-R124A complexed with SHLD3(37-73) To Be Published
5O8K	Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895 Descriptor: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B Authors: Emamzadah, S, Tropia, L, Huber, F, Halazonetis, T. Deposit date: 2017-06-13 Release date: 2018-06-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895 To Be Published
4EXT	Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta Descriptor: DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B, peptide from DNA polymerase zeta catalytic subunit Authors: Liu, D.N, Ryu, K.S, Ko, J.S, Choi, B.S. Deposit date: 2012-05-01 Release date: 2013-05-08 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Insights into the scaffold mechanism of human Rev1 in translesional synthesis revealed by structural studies on its polymerase-interacting domain To be Published
6M7A	Structure of REV7-R124A complexed with SHLD3(28-73) Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 3 Authors: Ma, Y.Z, Li, Y, Wu, B.X, Huang, H.D. Deposit date: 2020-03-18 Release date: 2021-01-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of REV7-R124A complexed with SHLD3(28-73) To Be Published
3ABD	Structure of human REV7 in complex with a human REV3 fragment in a monoclinic crystal Descriptor: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B Authors: Hara, K, Hashimoto, H, Murakumo, Y, Kobayashi, S, Kogame, T, Unzai, S, Akashi, S, Takeda, S, Shimizu, T, Sato, M. Deposit date: 2009-12-07 Release date: 2010-02-16 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase {zeta} and REV1 J.Biol.Chem., 285, 2010
2VFX	Structure of the Symmetric Mad2 Dimer Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, CHLORIDE ION, ... Authors: Yang, M, Li, B, Liu, C.-J, Tomchick, D.R, Machius, M, Rizo, J, Yu, H, Luo, X. Deposit date: 2007-11-05 Release date: 2008-03-18 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer. Plos Biol., 6, 2008
6VE5	X-ray structure of human REV7 in complex with Shieldin3 (residues 41-74) Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 Authors: Cui, G, Botuyan, M.V, Mer, G. Deposit date: 2019-12-28 Release date: 2021-01-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta. J.Biol.Chem., 297, 2021
6NIF	crystal structure of human REV7-RAN complex Descriptor: hREV7, GTP-binding nuclear protein Ran, hREV3 fusion Authors: Wang, X, Pertz, L, Hua, D.P, Zhang, T.Q, Listovsky, T, Xie, W. Deposit date: 2018-12-27 Release date: 2019-09-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.002 Å) Cite: REV7 has a dynamic adaptor region to accommodate small GTPase RAN/ShigellaIpaB ligands, and its activity is regulated by the RanGTP/GDP switch. J.Biol.Chem., 294, 2019
1GO4	Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20. Descriptor: Mitotic spindle assembly checkpoint protein MAD1, Mitotic spindle assembly checkpoint protein MAD2A Authors: Sironi, L, Mapelli, M, Jeang, K.T, Musacchio, A. Deposit date: 2001-10-17 Release date: 2002-05-16 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J., 21, 2002
5XPT	Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a tetragonal crystal Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B Authors: Hara, K, Taharazako, S, Hashimoto, H. Deposit date: 2017-06-05 Release date: 2017-09-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.102 Å) Cite: Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP). J. Biol. Chem., 292, 2017
6WS0	Rational drug design of phenazopyridine derivatives as novel inhibitors of Rev1-CT Descriptor: DNA polymerase zeta catalytic subunit, DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B Authors: McPherson, K.S, Korzhnev, D.M. Deposit date: 2020-04-30 Release date: 2020-12-23 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis. Chemmedchem, 16, 2021
6K07	Crystal structure of REV7(R124A) in complex with a Shieldin3 fragment Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 Authors: Zhang, F, Dai, Y. Deposit date: 2019-05-05 Release date: 2019-12-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair. J.Biol.Chem., 295, 2020
4AEZ	Crystal Structure of Mitotic Checkpoint Complex Descriptor: MITOTIC SPINDLE CHECKPOINT COMPONENT MAD2, MITOTIC SPINDLE CHECKPOINT COMPONENT MAD3, WD REPEAT-CONTAINING PROTEIN SLP1 Authors: Kulkarni, K.A, Chao, W.C.H, Zhang, Z, Barford, D. Deposit date: 2012-01-13 Release date: 2012-03-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the Mitotic Checkpoint Complex Nature, 484, 2012
4TZQ	Structure of C. elegans HTP-1 bound to HTP-3 motif-1 Descriptor: Protein HTP-1, Protein HTP-3 Authors: Rosenberg, S.C, Corbett, K.D. Deposit date: 2014-07-10 Release date: 2014-11-19 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins. Dev.Cell, 31, 2014
4TZM	C. elegans HTP-2 bound to HTP-3 closure motif 1 Descriptor: C. elegans HTP-3 closure motif1, Protein HTP-2 Authors: Rosenberg, S.C, Corbett, K.D. Deposit date: 2014-07-10 Release date: 2014-11-19 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins. Dev.Cell, 31, 2014
2QYF	Crystal structure of the Mad2/p31(comet)/Mad2-binding peptide ternary complex Descriptor: MAD2L1-binding protein, Mitotic spindle assembly checkpoint protein MAD2A, peptide Authors: Tomchick, D.R, Luo, X. Deposit date: 2007-08-14 Release date: 2008-01-29 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: p31comet blocks Mad2 activation through structural mimicry. Cell(Cambridge,Mass.), 131, 2007
5XPU	Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a monoclinic crystal Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B Authors: Hara, K, Taharazako, S, Hashimoto, H. Deposit date: 2017-06-05 Release date: 2017-09-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.304 Å) Cite: Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP). J. Biol. Chem., 292, 2017
6K08	Crystal structure of REV7(R124A/A135D) in complex with a Shieldin3 fragment Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 Authors: Zhang, F, Dai, Y. Deposit date: 2019-05-05 Release date: 2019-12-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.312 Å) Cite: Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair. J.Biol.Chem., 295, 2020
6KEA	crystal structure of MBP-tagged REV7-IpaB complex Descriptor: Maltose-binding periplasmic protein,LINKER,hREV7,LINKER,Invasin IpaB,hREV3 Authors: Wang, X, Pernicone, N, Pertz, L, Hua, D.P, Zhang, T.Q, Listovsky, T, Xie, W. Deposit date: 2019-07-04 Release date: 2019-09-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.35 Å) Cite: REV7 has a dynamic adaptor region to accommodate small GTPase RAN/ShigellaIpaB ligands, and its activity is regulated by the RanGTP/GDP switch. J.Biol.Chem., 294, 2019

 

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