1TVZ
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CRYSTAL STRUCTURE OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A SYNTHASE FROM STAPHYLOCOCCUS AUREUS
Descriptor:3-hydroxy-3-methylglutaryl-CoA synthase, SULFATE ION
Authors:Campobasso, N., Patel, M., Wilding, I.E., Kallender, H., Rosenberg, M., Gwynn, M.
Deposit date:2004-06-30
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism
J.Biol.Chem., 279, 2004
1TXT
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STAPHYLOCOCCUS AUREUS 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE
Descriptor:3-hydroxy-3-methylglutaryl-CoA synthase, ACETOACETYL-COENZYME A
Authors:Campobasso, N., Patel, M., Wilding, I.E., Kallender, H., Rosenberg, M., Gwynn, M.
Deposit date:2004-07-06
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism
J.Biol.Chem., 279, 2004
1X9E
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CRYSTAL STRUCTURE OF HMG-COA SYNTHASE FROM ENTEROCOCCUS FAECALIS
Descriptor:HMG-CoA synthase, SULFATE ION
Authors:Steussy, C.N., Vartia, A.A., Burgner II, J.W., Sutherlin, A., Rodwell, V.W., Stauffacher, C.V.
Deposit date:2004-08-20
Release date:2005-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA
Biochemistry, 44, 2005
1XPK
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH HMG-COA AND WITH ACETOACETYL-COA AND ACETYLATED CYSTEINE
Descriptor:3-hydroxy-3-methylglutaryl CoA synthase, SULFATE ION, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ...
Authors:Theisen, M.J., Misra, I., Saadat, D., Campobasso, N., Miziorko, H.M., Harrison, D.H.T.
Deposit date:2004-10-08
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004
1XPL
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH ACETOACETYL-COA AND ACETYLATED CYSTEINE
Descriptor:3-hydroxy-3-methylglutaryl CoA synthase, SULFATE ION, ACETOACETYL-COENZYME A
Authors:Theisen, M.J., Misra, I., Saadat, D., Campobasso, N., Miziorko, H.M., Harrison, D.H.T.
Deposit date:2004-10-08
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004
1XPM
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH HMG-COA AND ACETOACETYL-COA AND ACETYLATED CYSTEINE
Descriptor:3-hydroxy-3-methylglutaryl CoA synthase, SULFATE ION, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ...
Authors:Theisen, M.J., Misra, I., Saadat, D., Campobasso, N., Miziorko, H.M., Harrison, D.H.T.
Deposit date:2004-10-08
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004
1YSL
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CRYSTAL STRUCTURE OF HMG-COA SYNTHASE FROM ENTEROCOCCUS FAECALIS WITH ACETOACETYL-COA LIGAND.
Descriptor:HMG-CoA synthase, SULFATE ION, GLYCEROL, ...
Authors:Steussy, C.N., Vartia, A.A., Burgner II, J.W., Sutherlin, A., Rodwell, V.W., Stauffacher, C.V.
Deposit date:2005-02-08
Release date:2005-11-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA.
Biochemistry, 44, 2005
2HDB
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HMG-COA SYNTHASE FROM ENTEROCOCCUS FAECALIS. MUTATION ALANINE 110 TO GLYCINE
Descriptor:HMG-CoA synthase, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Steussy, C.N., Sutherlin, A., Stauffacher, C.V.
Deposit date:2006-06-20
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A structural limitation on enzyme activity: the case of HMG-CoA synthase.
Biochemistry, 45, 2006
2WYA
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CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2)
Descriptor:HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ...
Authors:Yue, W.W., Shafqat, N., Savitsky, P., Roos, A.K., Cooper, C., Murray, J.W., von Delft, F., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-11-13
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of Human Hmg-Coa Synthase Isoforms Provide Insights Into Inherited Ketogenesis Disorders and Inhibitor Design.
J.Mol.Biol., 398, 2010
3V4N
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THE BIOCHEMICAL AND STRUCTURAL BASIS FOR INHIBITION OF ENTEROCOCCUS FAECALIS HMG-COA SYNTHATSE, MVAS, BY HYMEGLUSIN
Descriptor:HMG-CoA synthase, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Skaff, D.A., Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V., Miziorko, H.M.
Deposit date:2011-12-15
Release date:2012-04-25
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.
Biochemistry, 51, 2012
3V4X
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THE BIOCHEMICAL AND STRUCTURAL BASIS FOR INHIBITION OF ENTEROCOCCUS FAECALIS HMG-COA SYNTHASE, MVAS, BY HYMEGLUSIN
Descriptor:HMG-CoA synthase, (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid
Authors:Skaff, D.A., Ramyar, K.X., McWhorter, W.J., Geisbrecht, B.V., Miziorko, H.M.
Deposit date:2011-12-15
Release date:2012-04-25
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.
Biochemistry, 51, 2012
4YXQ
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PKSG, A HMG-COA SYNTHASE FROM BACILLUS SUBTILIS
Descriptor:Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG, DI(HYDROXYETHYL)ETHER
Authors:Nair, A.V., Race, P.R., Till, M.
Deposit date:2015-03-23
Release date:2016-06-29
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:PksG, a HMG-CoA Synthase from Bacillus subtilis
To Be Published
4YXT
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PKSG, A HMG-COA SYNTHASE FROM BACILLUS SUBTILUS
Descriptor:Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
Authors:Till, M., Nair, A.V., Robson, A., Race, P.R.
Deposit date:2015-03-23
Release date:2016-06-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:PksG, a HMG-CoA Synthase from Bacillus subtilus
To Be Published
4YXV
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PKSG, A HMG-COA SYNTHASE FROM BACILLUS SUBTILUS
Descriptor:Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
Authors:Till, M., Nair, A.V., Robson, A., Race, P.R.
Deposit date:2015-03-23
Release date:2016-06-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:PksG, a HMG-CoA Synthase from Bacillus subtilus
To Be Published
5HWO
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MVAS IN COMPLEX WITH 3-HYDROXY-3-METHYLGLUTARYL COENZYME A
Descriptor:Hydroxymethylglutaryl-CoA synthase, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, ...
Authors:Bock, T., Kasten, J., Blankenfeldt, W.
Deposit date:2016-01-29
Release date:2016-05-11
Last modified:2016-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5HWP
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MVAS WITH ACETYLATED CYS115 IN COMPLEX WITH COENZYME A
Descriptor:Hydroxymethylglutaryl-CoA synthase, SULFATE ION, GLYCEROL, ...
Authors:Bock, T., Kasten, J., Blankenfeldt, W.
Deposit date:2016-01-29
Release date:2016-05-11
Last modified:2016-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5HWQ
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MVAS IN COMPLEX WITH ACETOACETYL COENZYME A
Descriptor:Hydroxymethylglutaryl-CoA synthase, ACETOACETYL-COENZYME A, GLYCEROL, ...
Authors:Bock, T., Kasten, J., Blankenfeldt, W.
Deposit date:2016-01-29
Release date:2016-05-11
Last modified:2016-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5HWR
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MVAS IN COMPLEX WITH COENZYME A
Descriptor:Hydroxymethylglutaryl-CoA synthase, GLYCEROL, SULFATE ION, ...
Authors:Bock, T., Kasten, J., Blankenfeldt, W.
Deposit date:2016-01-29
Release date:2016-05-11
Last modified:2016-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5KP5
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CRYSTAL STRUCTURE OF THE CURACIN BIOSYNTHETIC PATHWAY HMG SYNTHASE
Descriptor:CurD, SULFATE ION
Authors:Maloney, F.P., Smith, J.L.
Deposit date:2016-07-02
Release date:2016-08-31
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KP6
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CRYSTAL STRUCTURE OF THE CURACIN BIOSYNTHETIC PATHWAY HMG SYNTHASE IN COMPLEX WITH APO DONOR-ACP
Descriptor:CurD, CurB
Authors:Maloney, F.P., Smith, J.L.
Deposit date:2016-07-02
Release date:2016-08-31
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KP7
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CRYSTAL STRUCTURE OF THE CURACIN BIOSYNTHETIC PATHWAY HMG SYNTHASE IN COMPLEX WITH HOLO DONOR-ACP
Descriptor:CurD, CurB, SULFATE ION, ...
Authors:Maloney, F.P., Smith, J.L.
Deposit date:2016-07-02
Release date:2016-08-31
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KP8
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CRYSTAL STRUCTURE OF THE CURACIN BIOSYNTHETIC PATHWAY HMG SYNTHASE IN COMPLEX WITH ACETYL DONOR-ACP
Descriptor:CurD, CurB, 4'-PHOSPHOPANTETHEINE, ...
Authors:Maloney, F.P., Smith, J.L.
Deposit date:2016-07-02
Release date:2016-08-31
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016
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