3V4N

The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthatse, mvaS, by Hymeglusin

Summary for 3V4N

Entry DOI	10.2210/pdb3v4n/pdb
Related	3V4X
Descriptor	HMG-CoA synthase, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total)
Functional Keywords	hydroxymethylglutaryl-coa synthase, nitrosylation, transferase-inhibitor complex, transferase/inhibitor
Biological source	Enterococcus faecalis
Total number of polymer chains	4
Total formula weight	170712.96
Authors	Skaff, D.A.,Ramyar, K.X.,McWhorter, W.J.,Geisbrecht, B.V.,Miziorko, H.M. (deposition date: 2011-12-15, release date: 2012-04-25, Last modification date: 2014-09-10)
Primary citation	Skaff, D.A.,Ramyar, K.X.,McWhorter, W.J.,Barta, M.L.,Geisbrecht, B.V.,Miziorko, H.M. Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin. Biochemistry, 51:4713-4722, 2012 Cited by PubMed: 22510038 DOI: 10.1021/bi300037k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation