3V4N

The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthatse, mvaS, by Hymeglusin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
A	0006084	biological_process	acetyl-CoA metabolic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
A	0016746	molecular_function	acyltransferase activity
B	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
B	0006084	biological_process	acetyl-CoA metabolic process
B	0008299	biological_process	isoprenoid biosynthetic process
B	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
B	0016746	molecular_function	acyltransferase activity
C	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
C	0006084	biological_process	acetyl-CoA metabolic process
C	0008299	biological_process	isoprenoid biosynthetic process
C	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
C	0016746	molecular_function	acyltransferase activity
D	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
D	0006084	biological_process	acetyl-CoA metabolic process
D	0008299	biological_process	isoprenoid biosynthetic process
D	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
D	0016746	molecular_function	acyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BTB B 401

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Acyl-thioester intermediate => ECO:0000269\|PubMed:16245942