1XPM

Crystal Structure of Staphylococcus aureus HMG-COA Synthase with HMG-CoA and Acetoacetyl-COA and Acetylated Cysteine

Summary for 1XPM

Entry DOI	10.2210/pdb1xpm/pdb
Related	1XPK 1XPL
Descriptor	3-hydroxy-3-methylglutaryl CoA synthase, SULFATE ION, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ... (5 entities in total)
Functional Keywords	hmg-coa synthase, hmgs, coenzyme a, thiolase fold, condensing enzyme, cholesterol biosynthesis, transferase
Biological source	Staphylococcus aureus subsp. aureus
Total number of polymer chains	4
Total formula weight	185143.33
Authors	Theisen, M.J.,Misra, I.,Saadat, D.,Campobasso, N.,Miziorko, H.M.,Harrison, D.H.T. (deposition date: 2004-10-08, release date: 2004-11-02, Last modification date: 2023-08-23)
Primary citation	Theisen, M.J.,Misra, I.,Saadat, D.,Campobasso, N.,Miziorko, H.M.,Harrison, D.H.T. 3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time" Proc.Natl.Acad.Sci.USA, 47:16442-16447, 2004 Cited by PubMed: 15498869 DOI: 10.1073/pnas.0405809101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation