2WYA
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2)
Replaces: 2V4WSummary for 2WYA
| Entry DOI | 10.2210/pdb2wya/pdb |
| Descriptor | HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | steroid biosynthesis, cholesterol biosynthesis, mitochondria, mitochondrion, phosphoprotein, melavonate pathway, sterol biosynthesis, thiolase, acetylation, transferase, lipid synthesis, transit peptide, disease mutation |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Mitochondrion: P54868 |
| Total number of polymer chains | 4 |
| Total formula weight | 208982.43 |
| Authors | Yue, W.W.,Shafqat, N.,Savitsky, P.,Roos, A.K.,Cooper, C.,Murray, J.W.,von Delft, F.,Arrowsmith, C.,Wikstrom, M.,Edwards, A.,Bountra, C.,Oppermann, U. (deposition date: 2009-11-13, release date: 2009-11-24, Last modification date: 2023-12-20) |
| Primary citation | Shafqat, N.,Turnbull, A.,Zschocke, J.,Oppermann, U.,Yue, W.W. Crystal Structures of Human Hmg-Coa Synthase Isoforms Provide Insights Into Inherited Ketogenesis Disorders and Inhibitor Design. J.Mol.Biol., 398:497-, 2010 Cited by PubMed: 20346956DOI: 10.1016/J.JMB.2010.03.034 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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