2P8U

Crystal structure of human 3-hydroxy-3-methylglutaryl CoA synthase I

Summary for 2P8U

• Entry DOI: 10.2210/pdb2p8u/pdb
• Descriptor: Hydroxymethylglutaryl-CoA synthase, cytoplasmic, COENZYME A, GLYCEROL, ... (4 entities in total)
• Functional Keywords: hydromethylglutaryl coa, mevalonate pathway, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q01581
• Total number of polymer chains: 2
• Total formula weight: 108292.90

Authors

Turnbull, A.,Shafqat, N.,Salah, E.,Niesen, F.H.,Burgess, N.,Bunkoczi, G.,Debreczeni, J.,Pike, A.C.W.,Umeano, C.,Gorrec, F.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Sundstrom, M.,Edwards, A.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2007-03-23, release date: 2007-04-03, Last modification date: 2023-08-30)

• Primary citation: Shafqat, N.,Turnbull, A.,Zschocke, J.,Oppermann, U.,Yue, W.W.; Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.; J.Mol.Biol., 398:497-506, 2010; PubMed: 20346956; DOI: 10.1016/j.jmb.2010.03.034

Experimental method

X-RAY DIFFRACTION (2 Å)