2P8U

Crystal structure of human 3-hydroxy-3-methylglutaryl CoA synthase I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	polymer	478	53332.9	2	UniProt (Q01581) Pfam (PF01154) Pfam (PF08540)	Homo sapiens (human)	HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase
2	C, E (A, B)	COENZYME A	non-polymer		767.5	2	Chemie (COA)
3	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	F, G (A, B)	water	water		18.0	745	Chemie (HOH)

Sequence modifications

A, B: 16 - 470 (UniProt: Q01581)

PDB	External Database	Details
Met -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Ser 0	-	expression tag
Ser 1	-	expression tag
Gly 2	-	expression tag
Val 3	-	expression tag
Asp 4	-	expression tag
Leu 5	-	expression tag
Gly 6	-	expression tag
Thr 7	-	expression tag
Glu 8	-	expression tag
Asn 9	-	expression tag
Leu 10	-	expression tag
Tyr 11	-	expression tag
Phe 12	-	expression tag
Gln 13	-	expression tag
Ser 14	-	expression tag
Met 15	-	expression tag
Scy 129	Cys 129	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	106665.7
Non-Polymers*	Number of molecules	3
	Total formula weight	1627.2
All*	Total formula weight	108292.9

*Water molecules are not included.