2P8U
Crystal structure of human 3-hydroxy-3-methylglutaryl CoA synthase I
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | polymer | 478 | 53332.9 | 2 | UniProt (Q01581) Pfam (PF01154) Pfam (PF08540) In PDB | Homo sapiens (human) | HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase |
2 | A, B | COENZYME A | non-polymer | 767.5 | 2 | Chemie (COA) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | water | water | 18.0 | 745 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 470 (UniProt: Q01581)
PDB | External Database | Details |
---|---|---|
Met -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Ser 0 | - | expression tag |
Ser 1 | - | expression tag |
Gly 2 | - | expression tag |
Val 3 | - | expression tag |
Asp 4 | - | expression tag |
Leu 5 | - | expression tag |
Gly 6 | - | expression tag |
Thr 7 | - | expression tag |
Glu 8 | - | expression tag |
Asn 9 | - | expression tag |
Leu 10 | - | expression tag |
Tyr 11 | - | expression tag |
Phe 12 | - | expression tag |
Gln 13 | - | expression tag |
Ser 14 | - | expression tag |
Met 15 | - | expression tag |
Scy 129 | Cys 129 | modified residue |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 106665.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1627.2 | |
All* | Total formula weight | 108292.9 |