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8GK8	R21A Staphylococcus aureus pyruvate carboxylase Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, COENZYME A, ... Authors: Laseke, A.J, St.Maurice, M. Deposit date: 2023-03-17 Release date: 2023-08-30 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Allosteric Site at the Biotin Carboxylase Dimer Interface Mediates Activation and Inhibition in Staphylococcus aureus Pyruvate Carboxylase. Biochemistry, 62, 2023
8IH7	AmnG-AmnH complex Descriptor: 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, OXALATE ION, ... Authors: Su, D, Shi, Q.L. Deposit date: 2023-02-22 Release date: 2024-02-28 Method: X-RAY DIFFRACTION (2.48 Å) Cite: AmnG-AmnH complex To Be Published
8HWL	Human Pyruvate Carboxylase Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial Authors: Liu, D.S, Su, J.Y. Deposit date: 2022-12-30 Release date: 2024-01-31 Method: ELECTRON MICROSCOPY (5.63 Å) Cite: Human Pyruvate Carboxylase To Be Published
7ZZ4	Cryo-EM structure of "BC closed" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (2.63 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ8	Cryo-EM structure of Lactococcus lactis pyruvate carboxylase with acetyl-CoA and cyclic di-AMP Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (3.29 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ0	Cryo-EM structure of "CT empty" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: MAGNESIUM ION, MANGANESE (II) ION, Pyruvate carboxylase Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (2.26 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ2	Cryo-EM structure of "CT pyr" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: MAGNESIUM ION, MANGANESE (II) ION, PYRUVIC ACID, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.48 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ3	Cryo-EM structure of "BC react" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.41 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZYZ	Cryo-EM structure of "CT oxa" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: MANGANESE (II) ION, OXALOACETATE ION, Pyruvate carboxylase Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (2.47 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ5	Cryo-EM structure of "BC open" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: ACETYL COENZYME *A, BICARBONATE ION, Pyruvate carboxylase Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2022-10-26 Method: ELECTRON MICROSCOPY (2.43 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ1	Cryo-EM structure of "CT react" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: BIOTIN, MAGNESIUM ION, MANGANESE (II) ION, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (2.27 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZYY	Cryo-EM structure of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-10-12 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.12 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7ZZ6	Cryo-EM structure of "CT-CT dimer" of Lactococcus lactis pyruvate carboxylase with acetyl-CoA Descriptor: MAGNESIUM ION, MANGANESE (II) ION, PYRUVIC ACID, ... Authors: Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. Deposit date: 2022-05-25 Release date: 2022-12-28 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.15 Å) Cite: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
7WTA	Cryo-EM structure of human pyruvate carboxylase in apo state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
7WTC	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ... Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (4 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
7WTD	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ... Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
7WTE	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2 Descriptor: ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, Pyruvate carboxylase, ... Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
7WTB	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Chai, P, Lan, P, Wu, J, Lei, M. Deposit date: 2022-02-04 Release date: 2022-11-09 Last modified: 2022-11-16 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
6KTQ	Crystal structure of catalytic domain of homocitrate synthase from Sulfolobus acidocaldarius (SaHCS(dRAM)) in complex with alpha-ketoglutarate/Zn2+/CoA Descriptor: 2-OXOGLUTARIC ACID, COENZYME A, Homocitrate synthase, ... Authors: Suzuki, T, Tomita, T, Kuzuyama, T, Nishiyama, M. Deposit date: 2019-08-28 Release date: 2020-09-02 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius. Febs J., 288, 2021
6NDS	Structure of an HMG-CoA lyase from Acenitobacter baumannii in complex with coenzyme A and 3-methylmalate Descriptor: 1,2-ETHANEDIOL, 3-hydroxy-3-methylglutaryl-CoA lyase, ACETATE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-12-14 Release date: 2019-12-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure of an HMG-CoA lyase from Acenitobacter baumannii in complex with coenzyme A and 3-methylmalate to be published
6E1J	Crystal Structure of Methylthioalkylmalate Synthase (BjuMAM1.1) from Brassica juncea Descriptor: 2-isopropylmalate synthase, A genome specific 1, 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID, ... Authors: Lee, S.G, Jez, J.M. Deposit date: 2018-07-09 Release date: 2019-05-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Molecular Basis of the Evolution of Methylthioalkylmalate Synthase and the Diversity of Methionine-Derived Glucosinolates. Plant Cell, 31, 2019
5KS8	Crystal structure of two-subunit pyruvate carboxylase from Methylobacillus flagellatus Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, MANGANESE (II) ION, PYRUVIC ACID, ... Authors: Choi, P.H, Tong, L. Deposit date: 2016-07-07 Release date: 2016-10-19 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (3.01 Å) Cite: A distinct holoenzyme organization for two-subunit pyruvate carboxylase. Nat Commun, 7, 2016
4OV9	Structure of isopropylmalate synthase binding with alpha-isopropylmalate Descriptor: (2S)-2-hydroxy-2-(propan-2-yl)butanedioic acid, ZINC ION, isopropylmalate synthase Authors: Zhang, Z, Wu, J, Wang, C, Zhang, P. Deposit date: 2014-02-20 Release date: 2014-08-20 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition. J.Biol.Chem., 289, 2014
4OV4	Isopropylmalate synthase binding with ketoisovalerate Descriptor: 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, ZINC ION Authors: Zhang, Z, Wu, J, Wang, C, Zhang, P. Deposit date: 2014-02-20 Release date: 2014-08-20 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition. J.Biol.Chem., 289, 2014
4MIM	Structure of the carboxyl transferase domain from Rhizobium etli pyruvate carboxylase with 3-bromopyruvate Descriptor: Bromopyruvate, CHLORIDE ION, GLYCEROL, ... Authors: Lietzan, A.D, St.Maurice, M. Deposit date: 2013-09-01 Release date: 2014-08-13 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs. Biochem.Biophys.Res.Commun., 441, 2013

 

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