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8TA5
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BU of 8ta5 by Molmil
Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal
Descriptor: Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA4
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BU of 8ta4 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal
Descriptor: CHLORIDE ION, Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA2
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BU of 8ta2 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42
Descriptor: 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, CHLORIDE ION, Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA3
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BU of 8ta3 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved N-terminal hairpin
Descriptor: CHLORIDE ION, Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.46 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA6
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BU of 8ta6 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel C-terminal domain
Descriptor: Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (4.03 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8JPR
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BU of 8jpr by Molmil
Cryo-EM structure of Y553C human ClC-6
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, H(+)/Cl(-) exchange transporter 6, ...
Authors:Zhang, S.S.
Deposit date:2023-06-12
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular basis of ClC-6 function and its impairment in human disease
Sci Adv, 2023
8JPO
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BU of 8jpo by Molmil
Cryo-EM structure of ATP bound human ClC-6
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, H(+)/Cl(-) exchange transporter 6, ...
Authors:Zhang, S.S.
Deposit date:2023-06-12
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular basis of ClC-6 function and its impairment in human disease
Sci Adv, 2023
8JPJ
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BU of 8jpj by Molmil
Cryo-EM structure of ClC-6 apo state
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter 6
Authors:Zhang, S.S.
Deposit date:2023-06-12
Release date:2023-09-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Molecular basis of ClC-6 function and its impairment in human disease
Sci Adv, 2023
8JGK
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BU of 8jgk by Molmil
Cryo-EM structure of mClC-3 with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, H(+)/Cl(-) exchange transporter 3
Authors:Wan, Y.Z.Q, Yang, F.
Deposit date:2023-05-21
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (4.04 Å)
Cite:Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
8JGS
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BU of 8jgs by Molmil
Cryo-EM structure of apo state mClC-3_I607T
Descriptor: H(+)/Cl(-) exchange transporter 3
Authors:Wan, Y.Z.Q, Yang, F.
Deposit date:2023-05-21
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
8JGV
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BU of 8jgv by Molmil
Cryo-EM structure of mClC-3_I607T with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, H(+)/Cl(-) exchange transporter 3
Authors:Wan, Y.Z.Q, Yang, F.
Deposit date:2023-05-21
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
8JGJ
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BU of 8jgj by Molmil
Cryo-EM structure of mClC-3 with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, H(+)/Cl(-) exchange transporter 3
Authors:Wan, Y.Z.Q, Yang, F.
Deposit date:2023-05-20
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
8JEV
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BU of 8jev by Molmil
Cryo-EM structure of apo state mClC-3
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter 3
Authors:Wan, Y.Z.Q, Yang, F.
Deposit date:2023-05-16
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
8GA0
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BU of 8ga0 by Molmil
CLC-ec1 E202Y at pH 4.5 100mM Cl Turn
Descriptor: H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GAH
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BU of 8gah by Molmil
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GA3
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BU of 8ga3 by Molmil
CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Turn
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GA1
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BU of 8ga1 by Molmil
CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GA5
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BU of 8ga5 by Molmil
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
Deposit date:2023-02-22
Release date:2024-02-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8IAB
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BU of 8iab by Molmil
The Arabidopsis CLCa transporter bound with chloride, ATP and PIP2
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Chloride channel protein CLC-a, ...
Authors:Yang, Z, Zhang, X, Zhang, P.
Deposit date:2023-02-08
Release date:2023-08-02
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.
Nat Commun, 14, 2023
8IAD
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BU of 8iad by Molmil
The Arabidopsis CLCa transporter bound with nitrate, ATP and PIP2
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chloride channel protein CLC-a, MAGNESIUM ION, ...
Authors:Yang, Z, Zhang, X, Zhang, P.
Deposit date:2023-02-08
Release date:2023-08-02
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.
Nat Commun, 14, 2023
8HVT
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BU of 8hvt by Molmil
Structure of the human CLC-7/Ostm1 complex reveals a novel state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, H(+)/Cl(-) exchange transporter 7, Osteopetrosis-associated transmembrane protein 1, ...
Authors:Zhang, Z.X, Chen, L, He, J, She, J.
Deposit date:2022-12-27
Release date:2024-01-03
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the human CLC-7/Ostm1 complex reveals a novel state
JUSTC, 53, 2023
8GQU
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BU of 8gqu by Molmil
AK-42 inhibitor binding human ClC-2 TMD
Descriptor: 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2
Authors:Wang, L.
Deposit date:2022-08-30
Release date:2023-07-05
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42.
Nat Commun, 14, 2023
7XJA
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BU of 7xja by Molmil
TMD masked refine map of human ClC-2
Descriptor: Chloride channel protein 2
Authors:Wang, L.
Deposit date:2022-04-15
Release date:2023-05-17
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
7XF5
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BU of 7xf5 by Molmil
Full length human CLC-2 channel in apo state
Descriptor: Chloride channel protein 2
Authors:Wang, L.
Deposit date:2022-04-01
Release date:2023-05-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
7XA9
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BU of 7xa9 by Molmil
Structure of Arabidopsis thaliana CLCa
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chloride channel protein CLC-a, MAGNESIUM ION, ...
Authors:Ji, S, Jin, H, Kaiming, Z, Mingxing, W, Shanshan, L, Long, C.
Deposit date:2022-03-17
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Cryo-EM structure of the plant nitrate transporter AtCLCa reveals characteristics of the anion-binding site and the ATP-binding pocket.
J.Biol.Chem., 299, 2023

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PDB entries from 2024-09-18

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