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2IH3
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BU of 2ih3 by Molmil
Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ...
Authors:Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R.
Deposit date:2006-09-25
Release date:2006-11-21
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation.
Science, 314, 2006
1R3J
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BU of 1r3j by Molmil
potassium channel KcsA-Fab complex in high concentration of Tl+
Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ...
Authors:Zhou, Y, MacKinnon, R.
Deposit date:2003-10-02
Release date:2003-11-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
J.Mol.Biol., 333, 2003
1ORS
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BU of 1ors by Molmil
X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab
Descriptor: 33H1 Fab heavy chain, 33H1 Fab light chain, potassium channel
Authors:Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R.
Deposit date:2003-03-14
Release date:2003-05-06
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
2HVK
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BU of 2hvk by Molmil
crystal structure of the KcsA-Fab-TBA complex in high K+
Descriptor: (2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL LAURATE, Antibody Fab heavy chain, Antibody Fab light chain, ...
Authors:Zhou, Y.
Deposit date:2006-07-28
Release date:2007-02-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic Study of the Tetrabutylammonium Block to the KcsA K(+) Channel.
J.Mol.Biol., 366, 2007
8SR7
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BU of 8sr7 by Molmil
Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate
Descriptor: 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ...
Authors:Huang, Y, Kumar, S, Lu, W, Du, J.
Deposit date:2023-05-05
Release date:2024-05-08
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (1.97 Å)
Cite:Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Nat.Struct.Mol.Biol., 2024
7MIJ
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BU of 7mij by Molmil
Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3
Authors:Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
Deposit date:2021-04-17
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (1.98 Å)
Cite:Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Nat.Struct.Mol.Biol., 28, 2021
1K4C
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BU of 1k4c by Molmil
Potassium Channel KcsA-Fab complex in high concentration of K+
Descriptor: DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ...
Authors:Zhou, Y, Morais-Cabral, J.H, Kaufman, A, MacKinnon, R.
Deposit date:2001-10-07
Release date:2001-11-14
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
Nature, 414, 2001
6PA0
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BU of 6pa0 by Molmil
Structure of the G77A mutant in Sodium Chloride
Descriptor: Antibody HEAVY fragment, Antibody LIGHT fragment, DIACYL GLYCEROL, ...
Authors:Cuello, L.G, Guan, L.
Deposit date:2019-06-11
Release date:2019-08-07
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration.
Proc.Natl.Acad.Sci.USA, 116, 2019
2P7T
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BU of 2p7t by Molmil
Crystal Structure of KcsA mutant
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB-A, FAB-B, ...
Authors:Cordero-Morales, J.F, Vishwanath, J, Lewis, A, Valeria, V.R, Cortes, D.M, Roux, B, Perozo, E.
Deposit date:2007-03-20
Release date:2007-10-09
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of KcsA mutant
To be Published
4MSW
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BU of 4msw by Molmil
Y78 ester mutant of KcsA in high K+
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DIACYL GLYCEROL, ...
Authors:Matulef, K, Valiyaveetil, F.I.
Deposit date:2013-09-18
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K+ channels.
Proc.Natl.Acad.Sci.USA, 110, 2013
6NFU
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BU of 6nfu by Molmil
Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ...
Authors:Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G.
Deposit date:2018-12-20
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration.
Proc.Natl.Acad.Sci.USA, 116, 2019
7SQ9
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BU of 7sq9 by Molmil
Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution
Descriptor: (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30S,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gan, N, Han, Y, Jiang, Y.
Deposit date:2021-11-04
Release date:2022-02-02
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.11 Å)
Cite:Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
6NFV
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BU of 6nfv by Molmil
Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ...
Authors:Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G.
Deposit date:2018-12-20
Release date:2019-08-07
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration.
Proc.Natl.Acad.Sci.USA, 116, 2019
8SI5
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BU of 8si5 by Molmil
Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in open state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-8aH-4,8-methanobis[1]benzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ...
Authors:Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-04-14
Release date:2023-05-17
Method:ELECTRON MICROSCOPY (2.17 Å)
Cite:Structural mechanisms of TRPM7 activation and inhibition.
Nat Commun, 14, 2023
8SI2
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BU of 8si2 by Molmil
Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in apo state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, CHOLESTEROL, ...
Authors:Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-04-14
Release date:2023-05-17
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (2.19 Å)
Cite:Structural mechanisms of TRPM7 activation and inhibition.
Nat Commun, 14, 2023
8F0P
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BU of 8f0p by Molmil
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-1305
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C.
Deposit date:2022-11-03
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
6YZ2
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BU of 6yz2 by Molmil
Full length Open-form Sodium Channel NavMs F208L
Descriptor: DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ...
Authors:Sula, A, Sait, L.G, Hollingworth, D, Wallace, B.A.
Deposit date:2020-05-06
Release date:2020-11-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cannabidiol interactions with voltage-gated sodium channels.
Elife, 9, 2020
1S5H
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BU of 1s5h by Molmil
Potassium Channel Kcsa-Fab Complex T75C mutant in K+
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DIACYL GLYCEROL, ...
Authors:Mackinnon, R, Zhou, M.
Deposit date:2004-01-20
Release date:2004-05-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution.
J.Mol.Biol., 338, 2004
8U4D
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BU of 8u4d by Molmil
TRPV1 in nanodisc bound with PI-Br4, consensus structure
Descriptor: (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1
Authors:Arnold, W.R, Julius, D, Cheng, Y.
Deposit date:2023-09-10
Release date:2024-05-08
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
6SX5
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BU of 6sx5 by Molmil
Full length Mutant Open-form Sodium Channel NavMs
Descriptor: DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ...
Authors:Sula, A, Hollingworth, D, Wallace, B.A.
Deposit date:2019-09-25
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A tamoxifen receptor within a voltage-gated sodium channel.
Mol.Cell, 81, 2021
7W9K
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BU of 7w9k by Molmil
Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution
Descriptor: (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Yan, N, Huang, G, Liu, D, Wei, P, Shen, H.
Deposit date:2021-12-09
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV.
Cell Rep, 39, 2022
7UKG
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BU of 7ukg by Molmil
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region
Descriptor: Dipeptidyl-peptidase 6, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2
Authors:Zhao, H, Dai, Y, Lee, C.H.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.24 Å)
Cite:Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
2H8P
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BU of 2h8p by Molmil
Structure of a K channel with an amide to ester substitution in the selectivity filter
Descriptor: (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, FAB heavy chain, FAB light chain, ...
Authors:Valiyaveetil, F.I, MacKinnon, R, Muir, T.W.
Deposit date:2006-06-07
Release date:2006-09-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel.
J.Am.Chem.Soc., 128, 2006
5VKH
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BU of 5vkh by Molmil
Closed conformation of KcsA Y82A-F103A mutant
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Cuello, L.G, Perozo, E, Cortes, D.M.
Deposit date:2017-04-21
Release date:2017-12-06
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
5VK6
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BU of 5vk6 by Molmil
Open conformation of KcsA non-inactivating E71A mutant
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Cuello, L.G, Perozo, E.
Deposit date:2017-04-21
Release date:2017-12-06
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017

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