7SQ9
Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution
Summary for 7SQ9
Entry DOI | 10.2210/pdb7sq9/pdb |
EMDB information | 25380 |
Descriptor | Mucolipin-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, ... (6 entities in total) |
Functional Keywords | ion channel, membrane protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 271145.46 |
Authors | |
Primary citation | Gan, N.,Han, Y.,Zeng, W.,Wang, Y.,Xue, J.,Jiang, Y. Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin. Proc.Natl.Acad.Sci.USA, 119:-, 2022 Cited by PubMed: 35131932DOI: 10.1073/pnas.2120404119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.11 Å) |
Structure validation
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