7SQ9
Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Mucolipin-1 | polymer | 580 | 65573.6 | 4 | UniProt (Q99J21) Pfam (PF21381) Pfam (PF00520) Pfam (PF08016) | Mus musculus (house mouse) | Mucolipidin,Transient receptor potential-mucolipin 1,TRPML1 |
| 2 | E, F, G, H (E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | I, M, O, Q (A, B, C, D) | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate | non-polymer | 746.6 | 4 | Chemie (EUJ) | |||
| 4 | J, N, P, R (A, B, C, D) | (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30S,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate | non-polymer | 1030.3 | 4 | Chemie (A4I) | |||
| 5 | K, L (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 262294.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 7153.4 | |
| All* | Total formula weight | 271145.5 |
