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8QRW
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BU of 8qrw by Molmil
ASCT2 protomer in lipid nanodiscs under low Na+ concentration in the intermediate outward-facing state (iOFS-up)
Descriptor: Neutral amino acid transporter B(0), SODIUM ION
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8QRV
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BU of 8qrv by Molmil
ASCT2 protomer in lipid nanodiscs under low Na+ concentration in the outward-facing state (OFS)
Descriptor: Neutral amino acid transporter B(0), SODIUM ION
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8QRU
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BU of 8qru by Molmil
ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the intermediate outward-facing state (iOFS-down)
Descriptor: GLUTAMINE, Neutral amino acid transporter B(0)
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8QRS
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BU of 8qrs by Molmil
ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the intermediate outward-facing state (iOFS-up)
Descriptor: GLUTAMINE, Neutral amino acid transporter B(0)
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8QRR
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BU of 8qrr by Molmil
ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state (OFS.3)
Descriptor: GLUTAMINE, Neutral amino acid transporter B(0), SODIUM ION
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.78 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8QRQ
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BU of 8qrq by Molmil
ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state (OFS.2)
Descriptor: GLUTAMINE, Neutral amino acid transporter B(0), SODIUM ION
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8QRP
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BU of 8qrp by Molmil
ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state (OFS.1)
Descriptor: GLUTAMINE, Neutral amino acid transporter B(0), SODIUM ION
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8QRO
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BU of 8qro by Molmil
ASCT2 trimer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state (OFS)
Descriptor: GLUTAMINE, Neutral amino acid transporter B(0), SODIUM ION
Authors:Borowska, A, Rheinberger, J, Paulino, C, Slotboom, D.J.
Deposit date:2023-10-09
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of the obligatory exchange mode of human neutral amino acid transporter ASCT2.
Nat Commun, 15, 2024
8OUJ
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BU of 8ouj by Molmil
Heterotrimeric Complex of Human ASCT2 with Syncytin-1
Descriptor: ALANINE, Neutral amino acid transporter B(0), Syncytin-1
Authors:Khare, S, Reyes, N.
Deposit date:2023-04-23
Release date:2024-05-01
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins.
Nat.Struct.Mol.Biol., 2024
8OUH
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BU of 8ouh by Molmil
Complex of human ASCT2 with Syncytin-1
Descriptor: ALANINE, Neutral amino acid transporter B(0), Syncytin-1
Authors:Khare, S, Reyes, N.
Deposit date:2023-04-23
Release date:2024-05-01
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (2.62 Å)
Cite:Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins.
Nat.Struct.Mol.Biol., 2024
8OUD
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BU of 8oud by Molmil
Structure of the human neutral amino acid transporter ASCT2 in complex with nanobody 469
Descriptor: ALANINE, CHOLESTEROL HEMISUCCINATE, Nanobody 469, ...
Authors:Canul-Tec, J, Reyes, N.
Deposit date:2023-04-22
Release date:2024-05-01
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (2.31 Å)
Cite:Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins.
Nat.Struct.Mol.Biol., 2024
8CV3
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BU of 8cv3 by Molmil
Human Excitatory excitatory amino acid transporter 3 (EAAT3) protomer at in an intermediate outward facing sodium-bound state
Descriptor: Excitatory amino acid transporter 3, SODIUM ION
Authors:Qiu, B, Boudker, O.
Deposit date:2022-05-17
Release date:2023-05-10
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Symport and antiport mechanisms of human glutamate transporters.
Nat Commun, 14, 2023
8CV2
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BU of 8cv2 by Molmil
Human excitatory amino acid transporter 3 (EAAT3) in an outward facing sodium-bound state
Descriptor: Excitatory amino acid transporter 3, SODIUM ION
Authors:Qiu, B, Boudker, O.
Deposit date:2022-05-17
Release date:2023-05-10
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Symport and antiport mechanisms of human glutamate transporters.
Nat Commun, 14, 2023
8CUJ
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BU of 8cuj by Molmil
Human excitatory amino acid transporter 3 (EAAT3) protomer in an outward facing apo state in 150 mM NMDG-Cl
Descriptor: Excitatory amino acid transporter 3
Authors:Qiu, B, Boudker, O.
Deposit date:2022-05-17
Release date:2023-05-10
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Symport and antiport mechanisms of human glutamate transporters.
Nat Commun, 14, 2023
8CUI
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BU of 8cui by Molmil
Human excitatory amino acid transporter 3 (EAAT3) in an intermediate outward facing apo state
Descriptor: Excitatory amino acid transporter 3
Authors:Qiu, B, Boudker, O.
Deposit date:2022-05-17
Release date:2023-05-10
Last modified:2023-05-17
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Symport and antiport mechanisms of human glutamate transporters.
Nat Commun, 14, 2023
8CUD
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BU of 8cud by Molmil
Human excitatory amino acid transporter 3 (EAAT3) protomer in an outward facing apo state in 300 mM KCl
Descriptor: Excitatory amino acid transporter 3
Authors:Qiu, B, Boudker, O.
Deposit date:2022-05-17
Release date:2023-05-10
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Symport and antiport mechanisms of human glutamate transporters.
Nat Commun, 14, 2023
8CUA
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BU of 8cua by Molmil
Human excitatory amino acid transporter 3 (EAAT3) with bound potassium in an intermediate outward facing state
Descriptor: Excitatory amino acid transporter 3, MERCURY (II) ION, POTASSIUM ION
Authors:Qiu, B, Boudker, O.
Deposit date:2022-05-17
Release date:2023-05-10
Last modified:2023-05-17
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Symport and antiport mechanisms of human glutamate transporters.
Nat Commun, 14, 2023
8CTD
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BU of 8ctd by Molmil
Human excitatory amino acid transporter 3 (EAAT3) protomer with bound glutamate in an outward facing state
Descriptor: Excitatory amino acid transporter 3, GLUTAMIC ACID, MERCURY (II) ION, ...
Authors:Qiu, B, Boudker, O.
Deposit date:2022-05-14
Release date:2023-05-10
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Symport and antiport mechanisms of human glutamate transporters.
Nat Commun, 14, 2023
8CTC
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BU of 8ctc by Molmil
Human excitatory amino acid transporter 3 (EAAT3) with bound glutamate in an intermediate outward facing state
Descriptor: Excitatory amino acid transporter 3, GLUTAMIC ACID, MERCURY (II) ION, ...
Authors:Qiu, B, Boudker, O.
Deposit date:2022-05-13
Release date:2023-05-10
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Symport and antiport mechanisms of human glutamate transporters.
Nat Commun, 14, 2023
8AFA
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BU of 8afa by Molmil
Cryo-EM structure of a substrate-bound glutamate transporter homologue GltTk encapsulated within a nanodisc
Descriptor: ASPARTIC ACID, Proton/glutamate symporter, SDF family
Authors:Whittaker, J.J, Guskov, A.
Deposit date:2022-07-16
Release date:2023-04-05
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6.
Nat Commun, 14, 2023
7XR6
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BU of 7xr6 by Molmil
Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613
Descriptor: (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ...
Authors:Zhao, Y, Zhang, Z.
Deposit date:2022-05-09
Release date:2022-06-22
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of ligand binding modes of human EAAT2.
Nat Commun, 13, 2022
7XR4
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BU of 7xr4 by Molmil
Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, Excitatory amino acid transporter 2, ...
Authors:Zhao, Y, Zhang, Z.
Deposit date:2022-05-09
Release date:2022-06-22
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of ligand binding modes of human EAAT2.
Nat Commun, 13, 2022
7VR8
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BU of 7vr8 by Molmil
Inward-facing structure of human EAAT2 in the substrate-free state
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, ...
Authors:Kato, T, Kusakizako, T, Yamashita, K, Nishizawa, T, Nureki, O.
Deposit date:2021-10-22
Release date:2022-08-10
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
Nat Commun, 13, 2022
7VR7
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BU of 7vr7 by Molmil
Inward-facing structure of human EAAT2 in the WAY213613-bound state
Descriptor: (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Kato, T, Kusakizako, T, Yamashita, K, Nishizawa, T, Nureki, O.
Deposit date:2021-10-22
Release date:2022-08-10
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
Nat Commun, 13, 2022
7UH6
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BU of 7uh6 by Molmil
Asp-bound GltPh RSMR mutant in IFS-B2 state
Descriptor: ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION
Authors:Huang, Y, Boudker, O.
Deposit date:2022-03-25
Release date:2023-03-29
Last modified:2023-05-10
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM
J.Am.Chem.Soc., 145, 2023

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PDB entries from 2024-09-18

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