7VR7
Inward-facing structure of human EAAT2 in the WAY213613-bound state
Summary for 7VR7
Entry DOI | 10.2210/pdb7vr7/pdb |
EMDB information | 32097 |
Descriptor | Excitatory amino acid transporter 2, (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, ... (5 entities in total) |
Functional Keywords | transporter, membrane protein, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 66330.47 |
Authors | Kato, T.,Kusakizako, T.,Yamashita, K.,Nishizawa, T.,Nureki, O. (deposition date: 2021-10-22, release date: 2022-08-10, Last modification date: 2024-06-26) |
Primary citation | Kato, T.,Kusakizako, T.,Jin, C.,Zhou, X.,Ohgaki, R.,Quan, L.,Xu, M.,Okuda, S.,Kobayashi, K.,Yamashita, K.,Nishizawa, T.,Kanai, Y.,Nureki, O. Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2. Nat Commun, 13:4714-4714, 2022 Cited by PubMed: 35953475DOI: 10.1038/s41467-022-32442-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.49 Å) |
Structure validation
Download full validation report