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2RQ1
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BU of 2rq1 by Molmil
Solution structure of the 4.1R FERM alpha lobe domain
Descriptor: Protein 4.1
Authors:Kusunoki, H, Kohno, T.
Deposit date:2009-01-09
Release date:2009-04-14
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure and glycophorin C binding studies of the protein 4.1R FERM alpha-lobe domain
Proteins, 76, 2009
3U7D
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BU of 3u7d by Molmil
Crystal structure of the KRIT1/CCM1 FERM domain in complex with the heart of glass (HEG1) cytoplasmic tail
Descriptor: Krev interaction trapped protein 1, Protein HEG homolog 1
Authors:Gingras, A.R, Liu, J.J, Ginsberg, M.H, Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT)
Deposit date:2011-10-13
Release date:2012-09-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.
J.Cell Biol., 199, 2012
2HRJ
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BU of 2hrj by Molmil
NMR solution structure of the F2 subdomain of talin
Descriptor: Talin-1
Authors:Liu, G, Arroyo, M.M, Zheng, J.
Deposit date:2006-07-20
Release date:2008-04-29
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structural characterization of the talin F2 FERM subdomain with Coenzyme A and PI(4,5)P2
To be Published
4CYE
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BU of 4cye by Molmil
Crystal structure of avian FAK FERM domain FAK31-405 at 3.2A
Descriptor: FOCAL ADHESION KINASE 1
Authors:Goni, G.M, Epifano, C, Boskovic, J, Camacho-Artacho, M, Zhou, J, Martin, M.T, Eck, M.J, Kremer, L, Graeter, F, Gervasio, F.L, Perez-Moreno, M, Lietha, D.
Deposit date:2014-04-10
Release date:2014-04-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes.
Proc.Natl.Acad.Sci.USA, 111, 2014
6IBE
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BU of 6ibe by Molmil
The FERM domain of Human EPB41L3
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Band 4.1-like protein 3
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, Fernandez-Cid, A, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2018-11-29
Release date:2018-12-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The FERM domain of Human EPB41L3
To Be Published
1H4R
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BU of 1h4r by Molmil
Crystal Structure of the FERM domain of Merlin, the Neurofibromatosis 2 Tumor Suppressor Protein.
Descriptor: MERLIN, SULFATE ION
Authors:Cooper, D.R, Kang, B.S, Sheffield, P, Devedjiev, Y, Derewenda, Z.S.
Deposit date:2001-05-14
Release date:2002-01-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of the Ferm Domain of Merlin, the Neurofibromatosis Type 2 Gene Product.
Acta Crystallogr.,Sect.D, 58, 2002
1SGH
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BU of 1sgh by Molmil
Moesin FERM domain bound to EBP50 C-terminal peptide
Descriptor: Ezrin-radixin-moesin binding phosphoprotein 50, Moesin
Authors:Finnerty, C.M, Chambers, D, Ingraffea, J, Faber, H.R, Karplus, P.A, Bretscher, A.
Deposit date:2004-02-23
Release date:2004-06-29
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain
J.Cell.Sci., 117, 2004
6XTJ
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BU of 6xtj by Molmil
The high resolution structure of the FERM domain of human FERMT2
Descriptor: CITRIC ACID, Fermitin family homolog 2,Fermitin family homolog 2,Fermitin family homolog 2
Authors:Bradshaw, W.J, Katis, V.L, Newman, J.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2020-01-16
Release date:2020-02-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The high resolution structure of the FERM domain of human FERMT2
To Be Published
7LWH
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BU of 7lwh by Molmil
Human neurofibromin 2/merlin residues 1-339 in complex with LATS1
Descriptor: GLYCEROL, IMIDAZOLE, Merlin, ...
Authors:Primi, M.C, Rangarajan, E.S, Izard, T.
Deposit date:2021-03-01
Release date:2021-08-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.606 Å)
Cite:Conformational flexibility determines the Nf2/merlin tumor suppressor functions.
Matrix Biol Plus, 12, 2021
8Y8Y
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BU of 8y8y by Molmil
Crystal structure of the PTPN21 FERM domain
Descriptor: CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21
Authors:Lee, H.S, Ku, B.
Deposit date:2024-02-06
Release date:2024-07-10
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural analysis of the FERM domain of human protein tyrosine phosphatase non-receptor type 21.
Acta Crystallogr.,Sect.F, 80, 2024
6MFS
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BU of 6mfs by Molmil
Mouse talin1 residues 1-138 fused to residues 169-400 in complex with phosphatidylinositol 4,5-bisphosphate (PIP2)
Descriptor: PHOSPHATE ION, Talin-1 fusion, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Izard, T, Chinthalapudi, K, Rangarajan, E.S.
Deposit date:2018-09-12
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1Y19
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BU of 1y19 by Molmil
Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
Descriptor: Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma, Talin 1
Authors:de Pereda, J.M, Wegener, K, Santelli, E, Bate, N, Ginsberg, M.H, Critchley, D.R, Campbell, I.D, Liddington, R.C.
Deposit date:2004-11-17
Release date:2005-01-04
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural bases for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
J.Biol.Chem., 280, 2005
8GVL
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BU of 8gvl by Molmil
PTPN21 FERM
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-15
Release date:2023-09-20
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
5XBF
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BU of 5xbf by Molmil
Crystal Structure of Myo7b C-terminal MyTH4-FERM in complex with USH1C PDZ3
Descriptor: ACETATE ION, D-MALATE, GLYCEROL, ...
Authors:Li, J, He, Y, Weck, W.L, Lu, Q, Tyska, M.J, Zhang, M.
Deposit date:2017-03-17
Release date:2017-05-17
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5XQ1
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BU of 5xq1 by Molmil
Structural basis of kindlin-mediated integrin recognition and activation
Descriptor: Fermitin family homolog 2,Integrin beta-3
Authors:Li, H, Yang, H, Sun, K, Zhang, Z, Yu, C, Wei, Z.
Deposit date:2017-06-05
Release date:2017-07-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.954 Å)
Cite:Structural basis of kindlin-mediated integrin recognition and activation
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2AEH
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BU of 2aeh by Molmil
Focal adhesion kinase 1
Descriptor: Focal adhesion kinase 1
Authors:Ceccarelli, D.F, Song, H.K, Poy, F, Schaller, M.D, Eck, M.J.
Deposit date:2005-07-22
Release date:2005-10-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem., 281, 2006
1ISN
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BU of 1isn by Molmil
Crystal structure of merlin FERM domain
Descriptor: merlin
Authors:Shimizu, T, Seto, A, Maita, N, Hamada, K, Tsukita, S, Tsukita, S, Hakoshima, T.
Deposit date:2001-12-13
Release date:2002-04-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain.
J.Biol.Chem., 277, 2002
2AL6
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BU of 2al6 by Molmil
FERM domain of Focal Adhesion Kinase
Descriptor: Focal adhesion kinase 1
Authors:Ceccarelli, D.F, Song, H.K, Poy, F, Schaller, M.D, Eck, M.J.
Deposit date:2005-08-04
Release date:2005-10-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem., 281, 2006
1J19
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BU of 1j19 by Molmil
Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide
Descriptor: 16-mer peptide from Intercellular adhesion molecule-2, radixin
Authors:Hamada, K, Shimizu, T, Yonemura, S, Tsukita, S, Tsukita, S, Hakoshima, T.
Deposit date:2002-12-02
Release date:2003-03-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex
EMBO J., 22, 2003
6QLY
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BU of 6qly by Molmil
IDOL FERM domain
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase MYLIP, SULFATE ION
Authors:Martinelli, L, Sixma, T.K.
Deposit date:2019-02-01
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.
J.Biol.Chem., 295, 2020
3IVF
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BU of 3ivf by Molmil
Crystal structure of the talin head FERM domain
Descriptor: Talin-1
Authors:Elliott, P.R, Goult, B.T, Bate, N, Grossmann, J.G, Roberts, G.C.K, Critchley, D.R, Barsukov, I.L.
Deposit date:2009-09-01
Release date:2010-08-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:The Structure of the talin head reveals a novel extended conformation of the FERM domain
Structure, 18, 2010
4NY0
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BU of 4ny0 by Molmil
Crystal structure of FERM domain of human focal adhesion kinase
Descriptor: Focal adhesion kinase 1
Authors:Walkiewicz, K, Arold, S.T.
Deposit date:2013-12-10
Release date:2014-03-12
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:FAK dimerization controls its kinase-dependent functions at focal adhesions.
Embo J., 33, 2014
3G9W
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BU of 3g9w by Molmil
Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Integrin beta-1D, ...
Authors:Anthis, N.J, Wegener, K.L, Ye, F, Kim, C, Lowe, E.D, Vakonakis, I, Bate, N, Critchley, D.R, Ginsberg, M.H, Campbell, I.D.
Deposit date:2009-02-15
Release date:2009-10-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.165 Å)
Cite:The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
Embo J., 28, 2009
6R9T
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BU of 6r9t by Molmil
Cryo-EM structure of autoinhibited human talin-1
Descriptor: Talin-1
Authors:Dedden, D, Schumacher, S, Zacharias, M, Biertumpfel, C, Mizuno, N.
Deposit date:2019-04-04
Release date:2019-10-16
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:The Architecture of Talin1 Reveals an Autoinhibition Mechanism.
Cell, 179, 2019
8FSE
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BU of 8fse by Molmil
Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain
Descriptor: Integrin beta-2,Talin-1
Authors:Wu, J, Gao, T.
Deposit date:2023-01-09
Release date:2024-07-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Talin Bound to beta 2 Integrin Unveils the Molecular Mechanism of Species-Specific Integrin Activation
Biorxiv, 2024

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PDB entries from 2024-09-18

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