8FSE

Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain

Summary for 8FSE

• Entry DOI: 10.2210/pdb8fse/pdb
• Descriptor: Integrin beta-2,Talin-1 (2 entities in total)
• Functional Keywords: integrin, beta-2, talin, ferm, complex, cell adhesion
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 94812.93

Authors

Wu, J.,Gao, T. (deposition date: 2023-01-09, release date: 2024-07-03, Last modification date: 2025-05-07)

• Primary citation: Gao, T.,Maskalenko, N.A.,Kabir, S.,Campbell, K.S.,Wu, J.; Molecular basis of beta 2 integrin activation by talin unveils subunit-specific mechanisms of integrin signaling; Cell Rep, 44:115607-, 2025; DOI: 10.1016/j.celrep.2025.115607

Experimental method

X-RAY DIFFRACTION (1.9 Å)