3U7D

Crystal structure of the KRIT1/CCM1 FERM domain in complex with the heart of glass (HEG1) cytoplasmic tail

Summary for 3U7D

Entry DOI	10.2210/pdb3u7d/pdb
Descriptor	Krev interaction trapped protein 1, Protein HEG homolog 1 (3 entities in total)
Functional Keywords	psi-biology, assembly, dynamics and evolution of cell-cell and cell-matrix adhesions, cellmat, ferm domain, rap1 effector, membrane protein cytoplasmic tail, protein binding, structural genomics
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm, cytoskeleton: O00522 Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Isoform 2: Secreted (Potential): Q9ULI3
Total number of polymer chains	4
Total formula weight	81085.61
Authors	Gingras, A.R.,Liu, J.J.,Ginsberg, M.H.,Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT) (deposition date: 2011-10-13, release date: 2012-09-12, Last modification date: 2024-02-28)
Primary citation	Gingras, A.R.,Liu, J.J.,Ginsberg, M.H. Structural basis of the junctional anchorage of the cerebral cavernous malformations complex. J.Cell Biol., 199:39-48, 2012 Cited by PubMed: 23007647 DOI: 10.1083/jcb.201205109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation