6EL8
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CRYSTAL STRUCTURE OF THE FORKHEAD DOMAIN OF HUMAN FOXN1 IN COMPLEX WITH DNA
Descriptor:Forkhead box protein N1, DNA (5'-D(*GP*GP*TP*GP*GP*CP*GP*TP*CP*TP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*AP*GP*AP*CP*GP*CP*CP*AP*CP*C)-3')
Authors:Newman, J.A., Aitkenhead, H.A., Pinkas, D.M., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2017-09-28
Release date:2017-11-15
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal structure of the Forkhead domain of human FOXN1 in complex with DNA
To be published
5X07
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CRYSTAL STRUCTURE OF FOXA2 DNA BINDING DOMAIN BOUND TO A FULL CONSENSUS DNA SITE
Descriptor:DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), Hepatocyte nuclear factor 3-beta
Authors:Li, J., Guo, M., Zhou, Z., Jiang, L., Chen, X., Qu, L., Wu, D., Chen, Z., Chen, L., Chen, Y.
Deposit date:2017-01-20
Release date:2017-08-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.796 Å)
Cite:Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site
Biochemistry, 56, 2017
5OCN
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CRYSTAL STRUCTURE OF THE FORKHEAD DOMAIN OF HUMAN FOXN1
Descriptor:Forkhead box protein N1, POTASSIUM ION
Authors:Newman, J.A., Aitkenhead, H., Pinkas, D.M., von Delft, F., Arrowsmith, C.H., Edwwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-07-03
Release date:2017-08-02
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the forkhead domain of human FOXN1
To be published
5DUI
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IDENTIFICATION OF A NEW FOXO1 BINDING SITE THAT PRECLUDES CREB BINDING AT THE GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT GENE PROMOTER
Descriptor:Forkhead box protein O1, DNA (5'-D(*TP*TP*TP*TP*CP*TP*AP*TP*TP*TP*TP*AP*CP*GP*TP*AP*AP*AP*TP*CP*A)-3'), DNA (5'-D(*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*TP*AP*AP*AP*AP*TP*AP*GP*AP*AP*A)-3')
Authors:Singh, P., Endrizzi, J.A., Chi, Y.-I.
Deposit date:2015-09-18
Release date:2016-09-21
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Crystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter.
J. Struct. Biol., 198, 2017
4WK8
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FOXP3 FORMS A DOMAIN-SWAPPED DIMER TO BRIDGE DNA
Descriptor:DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), Forkhead box protein P3
Authors:Chen, Y., Chen, L.
Deposit date:2014-10-01
Release date:2015-01-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.4006 Å)
Cite:DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Nucleic Acids Res., 43, 2015
4LG0
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STRUCTURE OF A TERNARY FOXO1-ETS1 DNA COMPLEX
Descriptor:Forkhead box protein O1, Protein C-ets-1, DNA (5'-D(*DTP*DTP*DCP*DAP*DCP*DGP*DGP*DTP*DTP*DTP*DCP*DCP*DTP*DGP*DTP*DTP*DAP*DTP*DTP*DGP*DT)-3'), ...
Authors:Birrane, G., Choy, W.C., Datta, D., Geiger, C.A., Grant, M.A.
Deposit date:2013-06-27
Release date:2014-07-02
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structure of a ternary FOXO1-ETS1 DNA complex
To be Published
3QRF
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STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER
Descriptor:Nuclear factor of activated T-cells, cytoplasmic 2, Forkhead box protein P3, ...
Authors:Bandukwala, H.S., Wu, Y., Feurer, M., Chen, Y., Barbosa, B., Ghosh, S., Stroud, J.C., Benoist, C., Mathis, D., Rao, A., Chen, L.
Deposit date:2011-02-17
Release date:2011-04-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34, 2011
3G73
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STRUCTURE OF THE FOXM1 DNA BINDING
Descriptor:Forkhead box protein M1, DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3'), ...
Authors:Littler, D.R., Perrakis, A., Hibbert, R.G., Medema, R.H.
Deposit date:2009-02-09
Release date:2009-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
Nucleic Acids Res., 2010
3COA
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CRYSTAL STRUCTURE OF FOXO1 DBD BOUND TO IRE DNA
Descriptor:DNA (5'-D(*DTP*DGP*DGP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DG)-3'), DNA (5'-D(*DCP*DAP*DAP*DGP*DCP*DAP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DCP*DCP*DA)-3'), Forkhead box protein O1, ...
Authors:Brent, M.M., Anand, R., Marmorstein, R.
Deposit date:2008-03-27
Release date:2008-09-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification.
Structure, 16, 2008
3CO7
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CRYSTAL STRUCTURE OF FOXO1 DBD BOUND TO DBE2 DNA
Descriptor:DNA (5'-D(*DTP*DCP*DTP*DTP*DGP*DTP*DTP*DTP*DAP*DCP*DAP*DTP*DTP*DTP*DTP*DG)-3'), DNA (5'-D(*DCP*DAP*DAP*DAP*DAP*DTP*DGP*DTP*DAP*DAP*DAP*DCP*DAP*DAP*DGP*DA)-3'), Forkhead box protein O1
Authors:Brent, M.M., Anand, R., Marmorstein, R.
Deposit date:2008-03-27
Release date:2008-09-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification.
Structure, 16, 2008
3CO6
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CRYSTAL STRUCTURE OF FOXO1 DBD BOUND TO DBE1 DNA
Descriptor:DNA (5'-D(*DTP*DGP*DGP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DAP*DCP*DCP*DTP*DTP*DG)-3'), DNA (5'-D(*DCP*DAP*DAP*DGP*DGP*DTP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DCP*DCP*DA)-3'), Forkhead box protein O1, ...
Authors:Brent, M.M., Anand, R., Marmorstein, R.
Deposit date:2008-03-27
Release date:2008-09-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification.
Structure, 16, 2008
2UZK
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CRYSTAL STRUCTURE OF THE HUMAN FOXO3A-DBD BOUND TO DNA
Descriptor:FORKHEAD BOX PROTEIN O3A, 5'-D(*CP*TP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*AP*G)-3'
Authors:Tsai, K.-L., Sun, Y.-J., Huang, C.-Y., Yang, J.-Y., Hung, M.-C., Hsiao, C.-D.
Deposit date:2007-04-30
Release date:2008-05-13
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Human Foxo3A-Dbd/DNA Complex Suggests the Effects of Post-Translational Modification.
Nucleic Acids Res., 35, 2007
2KIU
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SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THE DNA-BINDING DOMAIN OF FOXP1: INSIGHT INTO ITS DOMAIN SWAPPING
Descriptor:Forkhead box protein P1
Authors:Chuang, W., Chu, Y.
Deposit date:2009-05-11
Release date:2010-04-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping and DNA binding.
Protein Sci., 20, 2011
2K86
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SOLUTION STRUCTURE OF FOXO3A FORKHEAD DOMAIN
Descriptor:Forkhead box protein O3
Authors:Wang, F., Marshall, C.B., Li, G., Plevin, M.J., Ikura, M.
Deposit date:2008-09-02
Release date:2008-10-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53.
J.Mol.Biol., 384, 2008
2HFH
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THE NMR STRUCTURES OF A WINGED HELIX PROTEIN: GENESIS, 20 STRUCTURES
Descriptor:GENESIS
Authors:Marsden, I., Jin, C., Liao, X.
Deposit date:1998-01-27
Release date:1998-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins.
J.Mol.Biol., 278, 1998
2HDC
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STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX
Descriptor:DNA (5'-D(P*GP*CP*TP*TP*AP*AP*AP*AP*TP*AP*AP*CP*AP*AP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*TP*TP*GP*TP*TP*AP*TP*TP*TP*TP*AP*AP*GP*C)-3'), PROTEIN (TRANSCRIPTION FACTOR)
Authors:Jin, C., Marsden, I., Chen, X., Liao, X.
Deposit date:1999-05-05
Release date:1999-07-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex.
J.Mol.Biol., 289, 1999
2D2W
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SOLUTION STRUCTURE AND DYNAMICS OF THE DNA-BINDING DOMAIN OF MYOCYTE NUCLEAR FACTOR
Descriptor:Forkhead box protein K1
Authors:Chuang, W.-J., Chang, C.-H., Jeng, W.-Y., Chu, Y.-P.
Deposit date:2005-09-19
Release date:2006-09-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure and Backbone Dynamics of the DNA-Binding Domain of Myocyte Nuclear Factor (Foxk1)
TO BE PUBLISHED
2C6Y
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CRYSTAL STRUCTURE OF INTERLEUKIN ENHANCER-BINDING FACTOR 1 BOUND TO DNA
Descriptor:FORKHEAD BOX PROTEIN K2, INTERLEUKIN 2 PROMOTOR, MAGNESIUM ION
Authors:Tsai, K.-L., Huang, C.-Y., Chang, C.-H., Sun, Y.-J., Chuang, W.-J., Hsiao, C.-D.
Deposit date:2005-11-15
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Human Foxk1A-DNA Complex and its Implications on the Diverse Binding Specificity of Winged Helix/Forkhead Proteins.
J.Biol.Chem., 281, 2006
2AS5
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STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT AND FOXP2 BOUND SPECIFICALLY TO DNA.
Descriptor:5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3', 5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3', Nuclear factor of activated T-cells, ...
Authors:Wu, Y., Stroud, J.C., Borde, M., Bates, D.L., Guo, L., Han, A., Rao, A., Chen, L.
Deposit date:2005-08-22
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT.
Cell(Cambridge,Mass.), 126, 2006
2A3S
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SOLUTION STRUCTURE AND DYNAMICS OF DNA-BINDING DOMAIN OF MYOCYTE NUCLEAR FACTOR
Descriptor:Myocyte Nuclear Factor
Authors:Chuang, W.-J., Chang, C.-H., Jeng, W.-Y., Chu, Y.-P.
Deposit date:2005-06-27
Release date:2006-06-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and Dynamics of DNA-Binding Domain of Myocyte Nuclear Factor
to be published
2A07
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CRYSTAL STRUCTURE OF FOXP2 BOUND SPECIFICALLY TO DNA.
Descriptor:5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3', 5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3', Forkhead box protein P2, ...
Authors:Stroud, J.C., Wu, Y., Bates, D.L., Han, A., Nowick, K., Paabo, S., Tong, H., Chen, L.
Deposit date:2005-06-16
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Forkhead Domain of FOXP2 Bound to DNA.
Structure, 14, 2006
1VTN
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CO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITION MOTIF RESEMBLES HISTONE H5
Descriptor:DNA (5'-D(*GP*AP*CP*TP*AP*AP*GP*TP*CP*AP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*TP*GP*AP*CP*TP*TP*AP*GP*TP*C)-3'), HNF-3/FORK HEAD DNA-RECOGNITION MOTIF, ...
Authors:Clark, K.L., Halay, E.D., Lai, E., Burley, S.K.
Deposit date:1995-01-06
Release date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Co-Crystal Structure of the HNF-3/Fork Head DNA-Recognition Motif Resembles Histone H5
Nature, 364, 1993
1KQ8
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SOLUTION STRUCTURE OF WINGED HELIX PROTEIN HFH-1
Descriptor:HEPATOCYTE NUCLEAR FACTOR 3 FORKHEAD HOMOLOG 1
Authors:Sheng, W., Rance, M., Liao, X.
Deposit date:2002-01-04
Release date:2002-01-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence.
Biochemistry, 41, 2002
1JXS
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SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF INTERLEUKIN ENHANCER BINDING FACTOR
Descriptor:interleukin enhancer binding factor
Authors:Chuang, W.J., Liu, P.P., Li, C., Hsieh, Y.H., Chen, S.W., Chen, S.H., Jeng, W.Y.
Deposit date:2001-09-08
Release date:2003-03-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)
PROTEINS: STRUCT.,FUNCT.,GENET., 49, 2002
1E17
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SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF THE HUMAN FORKHEAD TRANSCRIPTION FACTOR AFX (FOXO4)
Descriptor:AFX
Authors:Weigelt, J., Climent, I., Dahlman-Wright, K., Wikstrom, M.
Deposit date:2000-04-25
Release date:2000-08-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:1H, 13C and 15N Resonance Assignments of the DNA Binding Domain of the Human Forkhead Transcription Factor Afx
J.Biomol.NMR, 17, 2000
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