7YZE

Crystal structure of the human FoxA2 bound to the TGTTTACT site (forkhead motif GTAAACA)

Summary for 7YZE

• Entry DOI: 10.2210/pdb7yze/pdb
• Descriptor: Hepatocyte nuclear factor 3-beta, DNA (5'-D(*AP*GP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*GP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*CP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*CP*T)-3'), ... (6 entities in total)
• Functional Keywords: transcription factor, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 24581.37

Authors

Pluta, R.,Macias, M.J. (deposition date: 2022-02-19, release date: 2022-11-16, Last modification date: 2024-01-31)

• Primary citation: Pluta, R.,Aragon, E.,Prescott, N.A.,Ruiz, L.,Mees, R.A.,Baginski, B.,Flood, J.R.,Martin-Malpartida, P.,Massague, J.,David, Y.,Macias, M.J.; Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.; Nat Commun, 13:7279-7279, 2022; PubMed: 36435807; DOI: 10.1038/s41467-022-34925-y

Experimental method

X-RAY DIFFRACTION (1.99 Å)