7YZE

Crystal structure of the human FoxA2 bound to the TGTTTACT site (forkhead motif GTAAACA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00657
Number of Residues	14
Details	FORK_HEAD_1 Fork head domain signature 1. KPPYSYisLitm.AI

Chain	Residue	Details
A	LYS159-ILE172

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site_id	PS00658
Number of Residues	7
Details	FORK_HEAD_2 Fork head domain signature 2. WQNSIRH

Chain	Residue	Details
A	TRP203-HIS209

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	93
Details	DNA_BIND: Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089

Chain	Residue	Details
A	LYS159-GLN252

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P32182

Chain	Residue	Details
A	THR156

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P32182

Chain	Residue	Details
A	SER212

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