1DHR
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CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE
Descriptor:DIHYDROPTERIDINE REDUCTASE (DHPR) (E.C.1.6.99.10) COMPLEX WITH NADH
Authors:Varughese, K.I., Skinner, M.M., Whiteley, J.M., Matthews, D.A., Xuong, N.H.
Deposit date:1992-03-30
Release date:1993-07-15
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of rat liver dihydropteridine reductase.
Proc.Natl.Acad.Sci.USA, 89, 1992
1DIR
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CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER
Descriptor:DIHYDROPTERIDINE REDUCTASE (DHPR) (E.C.1.6.99.7)
Authors:Varughese, K.I., Su, Y., Skinner, M.M., Matthews, D.A., Whitely, J.M., Xuong, N.H.
Deposit date:1994-04-18
Release date:1994-07-31
Modification date:2014-02-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.
Acta Crystallogr.,Sect.D, 50, 1994
1HDR
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THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE
Descriptor:DIHYDROPTERIDINE REDUCTASE (DHPR) (E.C.1.6.99.7) COMPLEXED WITH NADH
Authors:Varughese, K.I., Su, Y., Xuong, N.H., Whiteley, J.M.
Deposit date:1993-08-18
Release date:1994-08-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue.
J.Biol.Chem., 268, 1993
4FDA
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CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE COMPLEXED WITH NADP
Descriptor:3-oxoacyl-[acyl-carrier-protein] reductase (E.C.1.1.1.100)
Authors:Yujie, Z., Yongxiang, G.
Deposit date:2012-05-27
Release date:2013-08-07
Modification date:2013-11-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Saccharomyces cerevisiae 3-oxoacyl-[acyl-carrier-protein] reductase complexed with NADPH
To be Published
3JQA
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 2-AMINO-1,9-DIHYDRO-6H-PURINE-6-THIONE (DX4)
Descriptor:Pteridine reductase 1 (E.C.1.5.1.33)
Authors:Tulloch, L.B., Hunter, W.N.
Deposit date:2009-09-06
Release date:2009-12-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
4CQM
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CRYSTAL STRUCTURE OF HETEROTETRAMERIC HUMAN KETOACYL REDUCTASE COMPLEXED WITH NAD AND NADP
Descriptor:ESTRADIOL 17-BETA-DEHYDROGENASE 8 (E.C.1.1.1.62, 1.1.1.239, 1.1.1.100), CARBONYL REDUCTASE FAMILY MEMBER 4 (E.C.1.1.1.100)
Authors:Venkatesan, R., SahTeli, S.K., Awoniyi, L.O., Jiang, G., Prus, P., Kastoniotis, A.J., Hiltunen, J.K., Wierenga, R.K., Chen, Z.
Deposit date:2014-02-19
Release date:2014-09-10
Modification date:2014-09-17
Method:X-RAY DIFFRACTION (2.339 Å)
Cite:Insights Into Mitochondrial Fatty Acid Synthesis from the Structure of Heterotetrameric 3-Ketoacyl-Acp Reductase/3R-Hydroxyacyl-Coa Dehydrogenase.
Nat.Commun., 5, 2014
4WCF
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR 9
Descriptor:Trypanosoma brucei brucei Pteridine reductase (E.C.1.5.1.33)
Authors:Mangani, S., Di Pisa, F., Pozzi, C.
Deposit date:2014-09-04
Release date:2015-09-23
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Studies of Thiadiazole Derivatives that Inhibit Trypanosoma Brucei Growth.
To Be Published
1E3W
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RAT BRAIN 3-HYDROXYACYL-COA DEHYDROGENASE BINARY COMPLEX WITH NADH AND 3-KETO BUTYRATE
Descriptor:SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE (E.C.1.1.1.35)
Authors:Powell, A.J., Read, J.A., Brady, R.L.
Deposit date:2000-06-26
Release date:2001-05-25
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of Structurally Diverse Substrates by Type II 3-Hydroxyacyl-Coa Dehydrogenase (Hadh II) Amyloid-Beta Binding Alcohol Dehydrogenase (Abad)
J.Mol.Biol., 303, 2000
2WD7
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PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00066750
Descriptor:PTERIDINE REDUCTASE (E.C.1.5.1.33)
Authors:Robinson, D.A., Wyatt, P.G., Spinks, D., Brenk, R.
Deposit date:2009-03-20
Release date:2009-06-30
Modification date:2012-10-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening.
J.Med.Chem., 52, 2009
2YHI
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TRYPANOSOMA BRUCEI PTR1 IN COMPLEX WITH INHIBITOR WH16
Descriptor:PTERIDINE REDUCTASE, PUTATIVE (E.C.1.5.1.33)
Authors:Nerini, E., Dawson, A., Hunter, W.N., Costi, M.P.
Deposit date:2011-05-03
Release date:2012-05-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Studies of Thiadiazole Derivatives that Inhibit Trypanosoma Brucei Growth.
To be Published
3BMC
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STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND SUBSTRATE (FOLATE)
Descriptor:Pteridine reductase
Authors:Tulloch, L.B., Hunter, W.N.
Deposit date:2007-12-13
Release date:2008-12-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3BMN
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STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR (COMPOUND AX3)
Descriptor:Pteridine reductase
Authors:Martini, V.P., Iulek, J., Tulloch, L.B., Hunter, W.N.
Deposit date:2007-12-13
Release date:2008-12-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3BMO
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STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR (COMPOUND AX4)
Descriptor:Pteridine reductase
Authors:Martini, V.P., Iulek, J., Hunter, W.N., Tulloch, L.B.
Deposit date:2007-12-13
Release date:2008-12-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3BMQ
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STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR (COMPOUND AX5)
Descriptor:Pteridine reductase
Authors:Martini, V.P., Iulek, J., Hunter, W.N.
Deposit date:2007-12-13
Release date:2008-12-16
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3D3W
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STRUCTURE OF L-XYLULOSE REDUCTASE WITH BOUND COENZYME, PHOSPHATE AND HYDROXIDE.
Descriptor:L-xylulose reductase (E.C.1.1.1.10)
Authors:Zhao, H.-T., El-Kabbani, O.
Deposit date:2008-05-12
Release date:2009-04-21
Modification date:2009-07-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase.
Cell.Mol.Life Sci., 66, 2009
3JQ7
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 6-PHENYLPTERIDINE-2,4,7-TRIAMINE (DX2)
Descriptor:Pteridine reductase 1 (E.C.1.5.1.33)
Authors:Tulloch, L.B., Hunter, W.N.
Deposit date:2009-09-06
Release date:2009-12-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3JQ8
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 6,7,7-TRIMETHYL-7,8-DIHYDROPTERIDINE-2,4-DIAMINE (DX3)
Descriptor:Pteridine reductase 1 (E.C.1.5.1.33)
Authors:Tulloch, L.B., Hunter, W.N.
Deposit date:2009-09-06
Release date:2009-12-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3JQ9
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 2-AMINO-6-(1,3-BENZODIOXOL-5-YL)-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE (AX1)
Descriptor:Pteridine reductase 1 (E.C.1.5.1.33)
Authors:Tulloch, L.B., Hunter, W.N.
Deposit date:2009-09-06
Release date:2009-12-08
Modification date:2010-01-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3JQB
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 2-AMINO-5-(2-PHENYLETHYL)-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE (DX6)
Descriptor:Pteridine reductase 1 (E.C.1.5.1.33)
Authors:Tulloch, L.B., Hunter, W.N.
Deposit date:2009-09-06
Release date:2009-12-08
Modification date:2010-01-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3JQF
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 1,3,5-TRIAZINE-2,4,6-TRIAMINE (AX2)
Descriptor:Pteridine reductase 1 (E.C.1.5.1.33)
Authors:Tulloch, L.B., Hunter, W.N.
Deposit date:2009-09-06
Release date:2009-12-08
Modification date:2012-12-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
3JQG
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 6-[(4-METHOXYBENZYL)SULFANYL]PYRIMIDINE-2,4-DIAMINE (AX6)
Descriptor:Pteridine reductase 1 (E.C.1.5.1.33)
Authors:Tulloch, L.B., Hunter, W.N.
Deposit date:2009-09-06
Release date:2009-12-08
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
4CLR
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR AND INHIBITOR
Descriptor:PTERIDINE REDUCTASE 1 (E.C.1.5.1.33)
Authors:Barrack, K.L., Hunter, W.N.
Deposit date:2014-01-15
Release date:2015-01-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.
J.Med.Chem., 57, 2014
4CM4
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR AND INHIBITOR
Descriptor:PTERIDINE REDUCTASE 1 (E.C.1.5.1.33)
Authors:Barrack, K.L., Hunter, W.N.
Deposit date:2014-01-15
Release date:2015-01-21
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.
J.Med.Chem., 57, 2014
4CM8
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR AND INHIBITOR
Descriptor:PTERIDINE REDUCTASE 1 (E.C.1.5.1.33)
Authors:Barrack, K.L., Hunter, W.N.
Deposit date:2014-01-15
Release date:2015-01-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.
J.Med.Chem., 57, 2014
4CM9
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CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR AND INHIBITOR
Descriptor:PTERIDINE REDUCTASE 1 (E.C.1.5.1.33)
Authors:Barrack, K.L., Hunter, W.N.
Deposit date:2014-01-15
Release date:2015-01-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.
J.Med.Chem., 57, 2014
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