Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complex with androstenedione and NADP

Summary for 1QYX

Related1IOL 1JTV 1QYV 1QYW
DescriptorEstradiol 17 beta-dehydrogenase 1, 4-ANDROSTENE-3-17-DIONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords17bhsd1, androstenedione, c19-steroid, nadp binding, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P14061
Total number of polymer chains1
Total molecular weight36009.74
Shi, R.,Lin, S.X. (deposition date: 2003-09-12, release date: 2004-08-03, Last modification date: 2017-10-11)
Primary citation
Shi, R.,Lin, S.X.
Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation.
J.Biol.Chem., 279:16778-16785, 2004
PubMed: 14966133 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M313156200
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers501.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report