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1K56
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BU of 1k56 by Molmil
OXA 10 class D beta-lactamase at pH 6.5
Descriptor: OXA10 beta-lactamase, SULFATE ION
Authors:Golemi, D, Maveyraud, L, Vakulenko, S, Samama, J.P, Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K6R
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BU of 1k6r by Molmil
STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH MOXALACTAM
Descriptor: (2R)-2-((R)-CARBOXY{[CARBOXY(4-HYDROXYPHENYL)ACETYL]AMINO}METHOXYMETHYL)-5-METHYLENE-5,6-DIHYDRO-2H-1,3-OXAZINE-4-CARBO XYLIC ACID, Beta-lactamase PSE-2
Authors:Kerff, F, Fonze, E, Sauvage, E, Frere, J.M, Charlier, P.
Deposit date:2001-10-17
Release date:2003-06-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CRYSTAL STRUCTURE OF CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH DIFFERENT SUBSTRATES AND ONE INHIBITOR.
To be Published
1K4E
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BU of 1k4e by Molmil
CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASES OXA-10 DETERMINED BY MAD PHASING WITH SELENOMETHIONINE
Descriptor: Beta-lactamase PSE-2, SULFATE ION
Authors:Kerff, F, Fonze, E, Bouillene, F, Frere, J.M, Charlier, P.
Deposit date:2001-10-08
Release date:2001-10-31
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:STRUCTURE OF CLASS D BETA-LACTAMASE OXA-2
To be Published
5E2F
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BU of 5e2f by Molmil
Crystal Structure of Beta-lactamase class D from Bacillus subtilis
Descriptor: 1,2-ETHANEDIOL, Beta-lactamase YbxI, CALCIUM ION
Authors:Kim, Y, Joachimiak, G, Endres, M, Babnigg, G, Joachimiak, A, MCSG, Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-10-01
Release date:2015-10-14
Last modified:2022-03-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal Structure of Beta-lactamase class D from Bacillus subtilis
To Be Published
2WGI
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BU of 2wgi by Molmil
Crystal structure of the acyl-enzyme OXA-10 W154A-benzylpenicillin at pH 6
Descriptor: BETA-LACTAMASE OXA-10, GLYCEROL, OPEN FORM - PENICILLIN G
Authors:Vercheval, L, Falzone, C, Sauvage, E, Herman, R, Charlier, P, Galleni, M, Kerff, F.
Deposit date:2009-04-20
Release date:2009-11-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Critical Role of Tryptophan 154 for the Activity and Stability of Class D Beta-Lactamases.
Biochemistry, 48, 2009
5CTN
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BU of 5ctn by Molmil
Structure of BPu1 beta-lactamase
Descriptor: (2~{S},3~{R})-3-methyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, Beta-lactamase, CITRATE ANION
Authors:Smith, C.A, Vakulenko, S.B.
Deposit date:2015-07-24
Release date:2015-11-25
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Class D beta-lactamases do exist in Gram-positive bacteria.
Nat.Chem.Biol., 12, 2016
4U3T
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BU of 4u3t by Molmil
Crystal structure of the transpeptidase domain of Neisseria gonorrhoeae penicillin-binding protein 2 derived from the penicillin-resistant strain 6140
Descriptor: Penicillin-binding protein 2
Authors:Fedarovich, A, Davies, C.
Deposit date:2014-07-22
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Effect of the Asp345a Insertion in Penicillin-Binding Protein 2 from Penicillin-Resistant Strains of Neisseria gonorrhoeae.
Biochemistry, 53, 2014
2WGV
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BU of 2wgv by Molmil
Crystal structure of the OXA-10 V117T mutant at pH 6.5 inhibited by a chloride ion
Descriptor: BETA-LACTAMASE OXA-10, CHLORIDE ION, CITRIC ACID, ...
Authors:Vercheval, L, Kerff, F, Bauvois, C, Sauvage, E, Guiet, R, Charlier, P, Galleni, M.
Deposit date:2009-04-27
Release date:2010-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three Factors that Modulate the Activity of Class D Beta-Lactamases and Interfere with the Post- Translational Carboxylation of Lys70.
Biochem.J., 432, 2010
5CXW
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BU of 5cxw by Molmil
Structure of the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V
Descriptor: (2R,4S)-5,5-dimethyl-2-{(1R)-2-oxo-1-[(phenoxyacetyl)amino]ethyl}-1,3-thiazolidine-4-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Filippova, E.V, Kiryukhina, O, Kieser, K, Endres, M, Rubin, E, Sacchettini, J, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
Deposit date:2015-07-29
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.
Febs J., 283, 2016
4S2L
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BU of 4s2l by Molmil
Crystal Structure of OXA-163 beta-lactamase
Descriptor: Beta-lactamase, SODIUM ION
Authors:Stojanoski, V, Liya, H, Palzkill, T.G, Prasad, B, Sankaran, B.
Deposit date:2015-01-21
Release date:2015-07-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural Basis for Different Substrate Profiles of Two Closely Related Class D beta-Lactamases and Their Inhibition by Halogens.
Biochemistry, 54, 2015
1K38
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BU of 1k38 by Molmil
CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-2
Descriptor: Beta-lactamase OXA-2, FORMIC ACID
Authors:Kerff, F, Fonze, E, Bouillenne, F, Frere, J.M, Charlier, P.
Deposit date:2001-10-02
Release date:2003-06-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-2
To be Published
3UY6
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BU of 3uy6 by Molmil
BlaR1 sensor domain from Staphylococcus aureus with N439V mutation
Descriptor: GLYCEROL, Regulatory protein BlaR1, SULFATE ION
Authors:Baker, B.M, Borbulevych, O.Y.
Deposit date:2011-12-05
Release date:2012-02-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An amino acid position at crossroads of evolution of protein function: antibiotic sensor domain of BlaR1 protein from Staphylococcus aureus versus clasS D beta-lactamases
J.Biol.Chem., 287, 2012
2WGW
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BU of 2wgw by Molmil
Crystal structure of the OXA-10 V117T mutant at pH 8.0
Descriptor: BETA-LACTAMASE OXA-10, GLYCEROL, SULFATE ION
Authors:Vercheval, L, Kerff, F, Bauvois, C, Sauvage, E, Guiet, R, Charlier, P, Galleni, M.
Deposit date:2009-04-27
Release date:2010-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three Factors that Modulate the Activity of Class D Beta-Lactamases and Interfere with the Post-Translational Carboxylation of Lys70.
Biochem.J., 432, 2010
5CRF
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BU of 5crf by Molmil
Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis
Descriptor: PHOSPHATE ION, Penicillin-binding protein 1A
Authors:Filippova, E.V, Wawrzak, Z, Kiryukhina, O, Kieser, K, Endres, M, Rubin, E, Sacchettini, J, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
Deposit date:2015-07-22
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.
Febs J., 283, 2016
4S2N
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BU of 4s2n by Molmil
OXA-48 in complex with Avibactam at pH 8.5
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase
Authors:King, D.T, Strynadka, N.C.J.
Deposit date:2015-01-21
Release date:2015-02-25
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Mechanism of Avibactam-Mediated beta-Lactamase Inhibition.
ACS Infect Dis, 1, 2015
5CTM
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BU of 5ctm by Molmil
Structure of BPu1 beta-lactamase
Descriptor: 1,2-ETHANEDIOL, Beta-lactamase, CITRATE ANION, ...
Authors:Smith, C.A, Vakulenko, S.B.
Deposit date:2015-07-24
Release date:2015-11-18
Last modified:2015-12-30
Method:X-RAY DIFFRACTION (1 Å)
Cite:Class D beta-lactamases do exist in Gram-positive bacteria.
Nat.Chem.Biol., 12, 2016
1K55
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BU of 1k55 by Molmil
OXA 10 class D beta-lactamase at pH 7.5
Descriptor: 1,2-ETHANEDIOL, Beta lactamase OXA-10, SULFATE ION
Authors:Golemi, D, Maveyraud, L, Vakulenko, S, Samama, J.P, Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
2X01
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BU of 2x01 by Molmil
CRYSTAL STRUCTURE OF THE OXA-10 S67A MUTANT AT PH 7
Descriptor: BETA-LACTAMASE OXA-10, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Vercheval, L, Kerff, F, Bauvois, C, Sauvage, E, Guiet, R, Galleni, M, Charlier, P.
Deposit date:2009-12-04
Release date:2010-12-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evidence of Chloride Inhibition and Impact of the Hydrophobic Core on the Lysine Carboxylated in Class D Beta-Lactamase
To be Published
2X02
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BU of 2x02 by Molmil
CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 AT 1.35 A RESOLUTION
Descriptor: BETA-LACTAMASE OXA-10, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Vercheval, L, Kerff, F, Sauvage, E, Herman, R, Galleni, M, Charlier, P.
Deposit date:2009-12-04
Release date:2010-12-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Impact of the Carboxylated Lysine on the Acylation and Deacylation Step in Class D Beta-Lactamase
To be Published
2WKH
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BU of 2wkh by Molmil
Crystal structure of the acyl-enzyme OXA-10 K70C-Ampicillin at pH 7
Descriptor: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, BETA-LACTAMASE OXA-10, SULFATE ION
Authors:Vercheval, L, Bauvois, C, Kerff, F, Sauvage, E, Guiet, R, Charlier, P, Galleni, M.
Deposit date:2009-06-11
Release date:2010-08-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.791 Å)
Cite:Three Factors that Modulate the Activity of Class D Beta-Lactamases and Interfere with the Post-Translational Carboxylation of Lys70.
Biochem.J., 432, 2010
2WKI
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BU of 2wki by Molmil
Crystal structure of the OXA-10 K70C mutant at pH 7.0
Descriptor: 1,2-ETHANEDIOL, BETA-LACTAMASE OXA-10, GLYCEROL, ...
Authors:Vercheval, L, Bauvois, C, Kerff, F, Sauvage, E, Guiet, R, Charlier, P, Galleni, M.
Deposit date:2009-06-11
Release date:2010-08-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Three Factors that Modulate the Activity of Class D Beta-Lactamases and Interfere with the Post-Translational Carboxylation of Lys70.
Biochem.J., 432, 2010
1K4F
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BU of 1k4f by Molmil
CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 AT 1.6 A RESOLUTION
Descriptor: Beta-lactamase PSE-2, SULFATE ION
Authors:Kerff, F, Fonze, E, Bouillene, F, Frere, J.M, Charlier, P.
Deposit date:2001-10-08
Release date:2001-10-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the class D beta-lactamase OXA-2
To be Published
1K54
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BU of 1k54 by Molmil
OXA-10 class D beta-lactamase partially acylated with reacted 6beta-(1-hydroxy-1-methylethyl) penicillanic acid
Descriptor: (1R)-2-(1-CARBOXY-2-HYDROXY-2-METHYL-PROPYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, 1,2-ETHANEDIOL, Beta lactamase OXA-10, ...
Authors:Golemi, D, Maveyraud, L, Vakulenko, S, Samama, J.P, Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
3ZNT
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BU of 3znt by Molmil
Crystal structure of OXA-24 class D beta-lactamase with tazobactam
Descriptor: BETA-LACTAMASE, SULFATE ION, TAZOBACTAM INTERMEDIATE
Authors:Power, P, Sauvage, E, Herman, R, Kerff, F, Charlier, P.
Deposit date:2013-02-18
Release date:2014-01-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Oxa-24 Beta-Lactamase Inhibited by Tazobactam
To be Published
7AUX
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BU of 7aux by Molmil
Crystal structure of OXA-48 beta-lactamase in the complex with the inhbitor ID2
Descriptor: 6-(4-carboxyphenyl)-3-(4-ethylphenyl)-2~{H}-pyrazolo[3,4-b]pyridine-4-carboxylic acid, Beta-lactamase, CHLORIDE ION
Authors:Pochetti, G, Montanari, R, Capelli, D, Garofalo, B, Ombrato, R.
Deposit date:2020-11-03
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of Novel Chemical Series of OXA-48 beta-Lactamase Inhibitors by High-Throughput Screening.
Pharmaceuticals, 14, 2021

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