5CRF
Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis
Summary for 5CRF
Entry DOI | 10.2210/pdb5crf/pdb |
Related | 5CXW |
Descriptor | Penicillin-binding protein 1A, PHOSPHATE ION (3 entities in total) |
Functional Keywords | b-lactam, pbp, structural genomics, psi-biology, midwest center for structural genomics, mcsg, structures of mtb proteins conferring susceptibility to known mtb inhibitors, mtbi, penicillin-binding protein |
Biological source | Mycobacterium tuberculosis |
Cellular location | Cell membrane ; Single-pass membrane protein : P71707 |
Total number of polymer chains | 4 |
Total formula weight | 179025.28 |
Authors | Filippova, E.V.,Wawrzak, Z.,Kiryukhina, O.,Kieser, K.,Endres, M.,Rubin, E.,Sacchettini, J.,Joachimiak, A.,Anderson, W.F.,Midwest Center for Structural Genomics (MCSG),Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) (deposition date: 2015-07-22, release date: 2016-05-04, Last modification date: 2016-07-06) |
Primary citation | Filippova, E.V.,Kieser, K.J.,Luan, C.H.,Wawrzak, Z.,Kiryukhina, O.,Rubin, E.J.,Anderson, W.F. Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. Febs J., 283:2206-2218, 2016 Cited by PubMed: 27101811DOI: 10.1111/febs.13738 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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