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4GMV
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BU of 4gmv by Molmil
Crystal Structure of the coiled-coil, RA and PH domains of Lamellipodin
Descriptor: Ras-associated and pleckstrin homology domains-containing protein 1
Authors:Chang, Y.C.E, Wu, J.
Deposit date:2012-08-16
Release date:2012-11-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling.
Protein Cell, 4, 2013
6DLU
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BU of 6dlu by Molmil
Cryo-EM of the GMPPCP-bound human dynamin-1 polymer assembled on the membrane in the constricted state
Descriptor: Dynamin-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Authors:Kong, L, Wang, H, Fang, S, Canagarajah, B, Kehr, A.D, Rice, W.J, Hinshaw, J.E.
Deposit date:2018-06-02
Release date:2018-08-01
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Cryo-EM of the dynamin polymer assembled on lipid membrane.
Nature, 560, 2018
4GN1
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BU of 4gn1 by Molmil
Crystal Structure of the RA and PH domains of Lamellipodin
Descriptor: MALONATE ION, Ras-associated and pleckstrin homology domains-containing protein 1
Authors:Chang, Y.C.E, Wu, J.
Deposit date:2012-08-16
Release date:2012-11-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling.
Protein Cell, 4, 2013
4GZU
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BU of 4gzu by Molmil
Crystal structure of the DH-PH-PH domain of FARP2
Descriptor: FERM, RhoGEF and pleckstrin domain-containing protein 2
Authors:He, X, Zhang, X.
Deposit date:2012-09-06
Release date:2013-03-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
1QQG
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BU of 1qqg by Molmil
CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
Descriptor: INSULIN RECEPTOR SUBSTRATE 1
Authors:Dhe-Paganon, S, Shoelson, S.E.
Deposit date:1999-06-04
Release date:1999-08-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
7C3M
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BU of 7c3m by Molmil
Structure of FERM protein
Descriptor: Fermitin family homolog 3,Fermitin family homolog 3,Fermitin family homolog 3
Authors:Bu, W, Loh, Z.Y, Jin, S, Basu, S, Ero, R, Park, J.E, Yan, X, Wang, M, Sze, S.K, Tan, S.M, Gao, Y.G.
Deposit date:2020-05-13
Release date:2020-06-03
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state.
Plos Biol., 18, 2020
6FSF
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BU of 6fsf by Molmil
Crystal structure of the tandem PX-PH-domains of Bem3 from Saccharomyces cerevisiae
Descriptor: GTPase-activating protein BEM3
Authors:Ali, I, Eu, S, Koch, D, Bleimling, N, Goody, R.S, Mueller, M.P.
Deposit date:2018-02-19
Release date:2018-05-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae.
Acta Crystallogr F Struct Biol Commun, 74, 2018
3LJU
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BU of 3lju by Molmil
Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3
Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, ZINC ION
Authors:Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2010-01-26
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MDB
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BU of 3mdb by Molmil
Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, Kinesin-like protein KIF13B, ...
Authors:Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2010-03-30
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.952 Å)
Cite:Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
to be published
7AX3
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BU of 7ax3 by Molmil
CryoEM structure of the super-constricted two-start dynamin 1 filament
Descriptor: Dynamin-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Authors:Liu, J.W, Zhang, P.J.
Deposit date:2020-11-09
Release date:2021-11-10
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:CryoEM structure of the super-constricted two-start dynamin 1 filament.
Nat Commun, 12, 2021
3MPX
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BU of 3mpx by Molmil
Crystal structure of the DH and PH-1 domains of human FGD5
Descriptor: FYVE, RhoGEF and PH domain-containing protein 5, UNKNOWN ATOM OR ION
Authors:Shen, Y, Nedyalkova, L, Tong, Y, Tempel, W, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2010-04-27
Release date:2010-06-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the DH and PH-1 domains of human FGD5
TO BE PUBLISHED
6TSE
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BU of 6tse by Molmil
Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
Descriptor: 1-methylindole-2,3-dione, MAGNESIUM ION, Tyrosine-protein kinase BTK, ...
Authors:Brear, P, Wagstaff, J, Hyvonen, M.
Deposit date:2019-12-20
Release date:2020-11-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
To Be Published
6U3E
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BU of 6u3e by Molmil
Best fitting antiparallel model for Volume 1 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)
Descriptor: Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Das, S, Lambright, D.G.
Deposit date:2019-08-21
Release date:2019-09-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (53 Å)
Cite:Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.
Structure, 27, 2019
6TVN
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BU of 6tvn by Molmil
Crystal Structure of 5-bromoindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase
Descriptor: 5-bromanyl-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ...
Authors:Brear, P, Wagstaff, J, Hyvonen, M.
Deposit date:2020-01-10
Release date:2020-11-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
To Be Published
3SNH
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BU of 3snh by Molmil
Crystal structure of nucleotide-free human dynamin1
Descriptor: Dynamin-1
Authors:Faelber, K, Daumke, O.
Deposit date:2011-06-29
Release date:2011-09-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of nucleotide-free dynamin.
Nature, 477, 2011
6TUH
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BU of 6tuh by Molmil
The PH domain of Bruton's tyrosine kinase mutant R28C
Descriptor: 4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid, MAGNESIUM ION, Tyrosine-protein kinase BTK, ...
Authors:Brear, P, Wagstaff, J, Hyvonen, M.
Deposit date:2020-01-07
Release date:2020-11-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
To Be Published
6TT2
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BU of 6tt2 by Molmil
The PH domain of Bruton's tyrosine kinase mutant R28C
Descriptor: MAGNESIUM ION, Tyrosine-protein kinase BTK, ZINC ION
Authors:Brear, P, Wagstaff, J, Hyvonen, M.
Deposit date:2019-12-23
Release date:2020-11-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
To Be Published
3TCA
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BU of 3tca by Molmil
Crystal structure of the Ras-associating and pleckstrin-homology domains of RIAM
Descriptor: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Authors:Wu, J, Hubbard, S.R.
Deposit date:2011-08-08
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.
J.Cell Biol., 199, 2012
6U3G
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BU of 6u3g by Molmil
Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)
Descriptor: Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Das, S, Lambright, D.G.
Deposit date:2019-08-21
Release date:2019-09-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (53 Å)
Cite:Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.
Structure, 27, 2019
4H8S
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BU of 4h8s by Molmil
Crystal structure of human APPL2BARPH domain
Descriptor: DCC-interacting protein 13-beta
Authors:Martin, J.L, King, G.J.
Deposit date:2012-09-23
Release date:2012-10-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Membrane Curvature Protein Exhibits Interdomain Flexibility and Binds a Small GTPase.
J.Biol.Chem., 287, 2012
4K2O
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BU of 4k2o by Molmil
The Structure of a Triple Mutant of the Tiam1 PH-CC-Ex Domain
Descriptor: T-lymphoma invasion and metastasis-inducing protein 1
Authors:Joshi, M, Gakhar, L, Fuentes, E.J.
Deposit date:2013-04-09
Release date:2013-07-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:High-resolution structure of the Tiam1 PHn-CC-Ex domain.
Acta Crystallogr.,Sect.F, 69, 2013
4K2P
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BU of 4k2p by Molmil
The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain
Descriptor: CALCIUM ION, T-lymphoma invasion and metastasis-inducing protein 1
Authors:Joshi, M, Gakhar, L, Fuentes, E.J.
Deposit date:2013-04-09
Release date:2013-07-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:High-resolution structure of the Tiam1 PHn-CC-Ex domain.
Acta Crystallogr.,Sect.F, 69, 2013
4H6Y
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BU of 4h6y by Molmil
Crystal structure of the DH-PH-PH domain of FARP1
Descriptor: FERM, RhoGEF and pleckstrin domain-containing protein 1
Authors:He, X, Zhang, X.
Deposit date:2012-09-19
Release date:2013-03-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.09 Å)
Cite:Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
2R0D
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BU of 2r0d by Molmil
Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor
Descriptor: Cytohesin-3, DI(HYDROXYETHYL)ETHER, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ...
Authors:DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G.
Deposit date:2007-08-18
Release date:2007-12-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors.
Mol.Cell, 28, 2007
2R09
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BU of 2r09 by Molmil
Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ...
Authors:DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G.
Deposit date:2007-08-17
Release date:2007-12-04
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors.
Mol.Cell, 28, 2007

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