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6TUH

The PH domain of Bruton's tyrosine kinase mutant R28C

Summary for 6TUH
Entry DOI10.2210/pdb6tuh/pdb
DescriptorTyrosine-protein kinase BTK, 4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsbtk, covalent fragments, surface entrophy reduction, crystal engineering, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight80984.61
Authors
Brear, P.,Wagstaff, J.,Hyvonen, M. (deposition date: 2020-01-07, release date: 2020-11-25, Last modification date: 2024-01-24)
Primary citationBrear, P.,Fischer, G.,May, M.,Pantelejevs, T.,Mathieu, R.,Rossmann, M.,Wagstaff, J.,Blaszczyk, B.,Hyvonen, M.
Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

217705

PDB entries from 2024-03-27

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