PDB: 595 resultsInfo pagesStatus searchChemie searchBIRD

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4P9V	Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PHQ-PTR-02K-ASN-NH2 Authors: Clements, J.H, Martin, S.F. Deposit date: 2014-04-06 Release date: 2014-06-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
4P9Z	Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2014-04-06 Release date: 2014-06-18 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP Descriptor: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
1SPS	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS Descriptor: PEPTIDE YEEI, SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1993-03-05 Release date: 1994-05-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1SKJ	COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX Descriptor: 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID, PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN Authors: Holland, D.R, Rubin, J.R. Deposit date: 1997-09-18 Release date: 1998-02-25 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40, 1997
1SHD	PEPTIDE INHIBITORS OF SRC SH3-SH2-PHOSPHOPROTEIN INTERACTIONS Descriptor: C-SRC TYROSINE KINASE SH2 DOMAIN, TRKA RECEPTOR Authors: Gilmer, T, Jordan, S. Deposit date: 1994-11-10 Release date: 1995-01-26 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem., 269, 1994
1SHB	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE B, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992
1SHA	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE A, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992
4EY0	Structure of tandem SH2 domains from PLCgamma1 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. Deposit date: 2012-05-01 Release date: 2012-10-31 Last modified: 2013-06-19 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
1R1Q	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY191 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
4F5A	Triple mutant Src SH2 domain bound to phosphate ion Descriptor: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F59	Triple mutant Src SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
1RJA	Solution Structure and Backbone Dynamics of the Nonreceptor Tyrosine Kinase PTK6/Brk SH2 Domain Descriptor: Tyrosine-protein kinase 6 Authors: Hong, E, Shin, J, Lee, W. Deposit date: 2003-11-18 Release date: 2004-07-20 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution Structure and Backbone Dynamics of the Non-receptor Protein-tyrosine Kinase-6 Src Homology 2 Domain J.Biol.Chem., 279, 2004
7Q63	The tandem SH2 domains of SYK Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. Deposit date: 2021-11-05 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The tandem SH2 domains of SYK To Be Published
7Q5W	The tandem SH2 domains of SYK with a bound TYROBP diphospho-ITAM peptide Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, ... Authors: Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. Deposit date: 2021-11-04 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The tandem SH2 domains of SYK To Be Published
1R1P	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY171 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2020-01-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1TZE	SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2) Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 Authors: Rahuel, J, Grutter, M.G. Deposit date: 1996-06-06 Release date: 1997-07-07 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. Nat.Struct.Biol., 3, 1996
1R1S	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY226 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1RPY	CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS Descriptor: SULFATE ION, adaptor protein APS Authors: Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. Deposit date: 2003-12-03 Release date: 2003-12-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
7RNV	SH2 domain of guanine nucleotide exchange factor Vav2 in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7RNS	nSH2 domain of p85-alpha subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.14 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7RNU	nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.45 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7R8W	Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide Descriptor: JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7R8X	Crystal Structure of the LNK SH2 Domain in Complex with an EPOR pY454 Phosphopeptide Descriptor: EPOR pY454 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021

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