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4ZI7
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BU of 4zi7 by Molmil
CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-HTI286 COMPLEX
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
Authors:Wang, Y, Zhang, R.
Deposit date:2015-04-27
Release date:2016-07-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules
Mol.Pharmacol., 89, 2016
5BMV
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BU of 5bmv by Molmil
CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-Vinblastine COMPLEX
Descriptor: (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Wang, Y, Chen, Q, Zhang, R.
Deposit date:2015-05-23
Release date:2016-07-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules.
Mol.Pharmacol., 89, 2016
5UBQ
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BU of 5ubq by Molmil
Cryo-EM structure of ciliary microtubule doublet
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ichikawa, M, Liu, D, Kastritis, P.L, Basu, K, Bui, K.H.
Deposit date:2016-12-21
Release date:2017-05-10
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins.
Nat Commun, 8, 2017
6EG5
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BU of 6eg5 by Molmil
The structure of SB-1-202-tubulin complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloropyrido[2,3-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ...
Authors:Banerjee, A.K, Wang, Y, Chen, H, Miller, D, Li, W.
Deposit date:2018-08-18
Release date:2019-08-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The structure of SB-1-202/SB-2-204-tubulin complex
To Be Published
4M8I
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BU of 4m8i by Molmil
1.43 Angstrom resolution crystal structure of cell division protein FtsZ (ftsZ) from Staphylococcus epidermidis RP62A in complex with GDP
Descriptor: Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:Halavaty, A.S, Minasov, G, Winsor, J, Dubrovska, I, Filippova, E.V, Olsen, D.B, Therien, A, Shuvalova, L, Young, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-08-13
Release date:2013-09-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:1.43 Angstrom resolution crystal structure of cell division protein FtsZ (ftsZ) from Staphylococcus epidermidis RP62A in complex with GDP
To be Published
4UXP
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BU of 4uxp by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-3 MOTOR DOMAIN, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
4UXY
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BU of 4uxy by Molmil
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Descriptor: ALPHA TUBULIN, BETA TUBULIN, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
6EW0
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BU of 6ew0 by Molmil
Cryo-EM structure of GDP-microtubule co-polymerised with doublecortin and supplemented with Taxol
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Manka, S.W.
Deposit date:2017-11-03
Release date:2018-07-04
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability.
Nat. Struct. Mol. Biol., 25, 2018
6EVZ
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BU of 6evz by Molmil
Cryo-EM structure of GDP-microtubule co-polymerised with doublecortin
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Manka, S.W.
Deposit date:2017-11-03
Release date:2018-07-04
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability.
Nat. Struct. Mol. Biol., 25, 2018
6EVW
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BU of 6evw by Molmil
Cryo-EM structure of GMPCPP-microtubule co-polymerised with doublecortin
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Manka, S.W.
Deposit date:2017-11-02
Release date:2018-07-04
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability.
Nat. Struct. Mol. Biol., 25, 2018
6EVX
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BU of 6evx by Molmil
Cryo-EM structure of GDP.Pi-microtubule rapidly co-polymerised with doublecortin
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Manka, S.W.
Deposit date:2017-11-03
Release date:2018-07-11
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability.
Nat. Struct. Mol. Biol., 25, 2018
6FJM
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BU of 6fjm by Molmil
tubulin-Disorazole Z complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Disorazole Z, ...
Authors:Menchon, G, Prota, A.E, Lucena Agell, D, Bucher, P, Jansen, R, Irschik, H, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O.
Deposit date:2018-01-22
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6EVY
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BU of 6evy by Molmil
Cryo-EM structure of GTPgammaS-microtubule co-polymerised with doublecortin
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Manka, S.W.
Deposit date:2017-11-03
Release date:2018-07-04
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability.
Nat. Struct. Mol. Biol., 25, 2018
4X1K
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BU of 4x1k by Molmil
Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications
Descriptor: 2-methyl-L-alanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Parris, K.D.
Deposit date:2014-11-24
Release date:2015-03-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
J.Med.Chem., 57, 2014
1RQ2
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BU of 1rq2 by Molmil
MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH CITRATE
Descriptor: CITRIC ACID, Cell division protein ftsZ
Authors:Leung, A.K.W, White, E.L, Ross, L.J, Reynolds, R.C, DeVito, J.A, Borhani, D.W.
Deposit date:2003-12-04
Release date:2004-08-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
J.Mol.Biol., 342, 2004
1RLU
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BU of 1rlu by Molmil
Mycobacterium tuberculosis FtsZ in complex with GTP-gamma-S
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Cell division protein ftsZ, GLYCEROL
Authors:Leung, A.K.W, White, E.L, Ross, L.J, Reynolds, R.C, DeVito, J.A, Borhani, D.W.
Deposit date:2003-11-26
Release date:2004-08-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
J.Mol.Biol., 342, 2004
4X20
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BU of 4x20 by Molmil
Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications
Descriptor: 2-methyl-L-prolyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Parris, K.D.
Deposit date:2014-11-25
Release date:2015-03-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
J.Med.Chem., 57, 2014
4X1I
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BU of 4x1i by Molmil
Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications
Descriptor: 2-methyl-L-alanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Parris, K.D.
Deposit date:2014-11-24
Release date:2015-03-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
J.Med.Chem., 57, 2014
1SA0
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BU of 1sa0 by Molmil
TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX
Descriptor: 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Ravelli, R.B, Gigant, B, Curmi, P.A, Jourdain, I, Lachkar, S, Sobel, A, Knossow, M.
Deposit date:2004-02-06
Release date:2004-03-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
Nature, 428, 2004
4X1Y
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BU of 4x1y by Molmil
Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Parris, K.D.
Deposit date:2014-11-25
Release date:2015-03-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
J.Med.Chem., 57, 2014
1RQ7
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BU of 1rq7 by Molmil
MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH GDP
Descriptor: Cell division protein ftsZ, GUANOSINE-5'-DIPHOSPHATE
Authors:Leung, A.K.W, White, E.L, Ross, L.J, Reynolds, R.C, DeVito, J.A, Borhani, D.W.
Deposit date:2003-12-04
Release date:2004-08-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
J.Mol.Biol., 342, 2004
4XCQ
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BU of 4xcq by Molmil
Clostridium botulinum phage c-st TubZ (C-terminal tail truncated protein)
Descriptor: GUANOSINE-5'-DIPHOSPHATE, SODIUM ION, TubZ
Authors:Oliva, M.A.
Deposit date:2014-12-18
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of phage c-st truncated TubZ at 2.4 Angstroms resolution
To Be Published
4O2B
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BU of 4o2b by Molmil
Tubulin-Colchicine complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Prota, A.E, Franck, D, Bachmann, F, Bargsten, K, Buey, R.M, Pohlmann, J, Reinelt, S, Lane, H, Steinmetz, M.O.
Deposit date:2013-12-17
Release date:2014-03-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization.
J.Mol.Biol., 426, 2014
4O4J
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BU of 4o4j by Molmil
Tubulin-Peloruside A complex
Descriptor: CALCIUM ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Prota, A.E, Bargsten, K, Northcote, P.T, Marsh, M, Altmann, K.H, Miller, J.H, Diaz, J.F, Steinmetz, M.O.
Deposit date:2013-12-18
Release date:2014-03-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of microtubule stabilization by laulimalide and peloruside A.
Angew.Chem.Int.Ed.Engl., 53, 2014
4O4H
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BU of 4o4h by Molmil
Tubulin-Laulimalide complex
Descriptor: CALCIUM ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Prota, A.E, Bargsten, K, Northcote, P.T, Marsh, M, Altmann, K.H, Miller, J.H, Diaz, J.F, Steinmetz, M.O.
Deposit date:2013-12-18
Release date:2014-03-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of microtubule stabilization by laulimalide and peloruside a.
Angew.Chem.Int.Ed.Engl., 53, 2014

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