4X20

Discovery of cytotoxic Dolastatin 10 analogs with N-terminal modifications

Summary for 4X20

• Entry DOI: 10.2210/pdb4x20/pdb
• Related: 4X1I 4X1K 4X1Y
• Related PRD ID: PRD_002153
• Descriptor: Tubulin alpha chain, Tubulin beta chain, Stathmin-4, ... (8 entities in total)
• Functional Keywords: binding sites, competitive, cattle, tumor, colchicine, humans, microtubules, protein binding, protein conformation, protein multimerization, tubulin, tubulin modulators, structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton : D0VWY9; Golgi apparatus : P63043
• Total number of polymer chains: 5
• Total formula weight: 221276.55

Authors

Parris, K.D. (deposition date: 2014-11-25, release date: 2015-03-25, Last modification date: 2023-09-27)

• Primary citation: Maderna, A.,Doroski, M.,Subramanyam, C.,Porte, A.,Leverett, C.A.,Vetelino, B.C.,Chen, Z.,Risley, H.,Parris, K.,Pandit, J.,Varghese, A.H.,Shanker, S.,Song, C.,Sukuru, S.C.,Farley, K.A.,Wagenaar, M.M.,Shapiro, M.J.,Musto, S.,Lam, M.H.,Loganzo, F.,O'Donnell, C.J.; Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.; J.Med.Chem., 57:10527-10543, 2014; PubMed: 25431858; DOI: 10.1021/jm501649k

Experimental method

X-RAY DIFFRACTION (3.5 Å)