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1RDH
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CRYSTALLOGRAPHIC ANALYSES OF AN ACTIVE HIV-1 RIBONUCLEASE H DOMAIN SHOW STRUCTURAL FEATURES THAT DISTINGUISH IT FROM THE INACTIVE FORM
Descriptor: HIV-1 REVERSE TRANSCRIPTASE (RIBONUCLEASE H DOMAIN)
Authors:Finzel, B.C, Chattopadhyay, D, Einspahr, H.M.
Deposit date:1993-03-05
Release date:1994-05-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic analyses of an active HIV-1 ribonuclease H domain show structural features that distinguish it from the inactive form.
Acta Crystallogr.,Sect.D, 49, 1993
1RBU
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STRUCTURAL STUDY OF MUTANTS OF ESCHERICHIA COLI RIBONUCLEASE HI WITH ENHANCED THERMOSTABILITY
Descriptor: RIBONUCLEASE H
Authors:Ishikawa, K, Kimura, S, Kanaya, S, Morikawa, K, Nakamura, H.
Deposit date:1993-02-16
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability.
Protein Eng., 6, 1993
1RDD
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BU of 1rdd by Molmil
CRYSTAL STRUCTURE OF ESCHERICHIA COLI RNASE HI IN COMPLEX WITH MG2+ AT 2.8 ANGSTROMS RESOLUTION: PROOF FOR A SINGLE MG2+ SITE
Descriptor: MAGNESIUM ION, RIBONUCLEASE H
Authors:Katayanagi, K, Morikawa, K.
Deposit date:1993-06-23
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Escherichia coli RNase HI in complex with Mg2+ at 2.8 A resolution: proof for a single Mg(2+)-binding site.
Proteins, 17, 1993
1RBT
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BU of 1rbt by Molmil
STRUCTURAL STUDY OF MUTANTS OF ESCHERICHIA COLI RIBONUCLEASE HI WITH ENHANCED THERMOSTABILITY
Descriptor: RIBONUCLEASE H
Authors:Ishikawa, K, Kimura, S, Kanaya, S, Morikawa, K, Nakamura, H.
Deposit date:1993-02-16
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability.
Protein Eng., 6, 1993
1RBR
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BU of 1rbr by Molmil
STRUCTURAL STUDY OF MUTANTS OF ESCHERICHIA COLI RIBONUCLEASE HI WITH ENHANCED THERMOSTABILITY
Descriptor: RIBONUCLEASE H
Authors:Ishikawa, K, Kimura, S, Kanaya, S, Morikawa, K, Nakamura, H.
Deposit date:1993-02-16
Release date:1994-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural study of mutants of Escherichia coli ribonuclease HI with enhanced thermostability.
Protein Eng., 6, 1993
1RDA
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BU of 1rda by Molmil
CRYSTAL STRUCTURES OF RIBONUCLEASE HI ACTIVE SITE MUTANTS FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEASE H
Authors:Katayanagi, K, Morikawa, K.
Deposit date:1993-06-23
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structures of ribonuclease HI active site mutants from Escherichia coli.
J.Biol.Chem., 268, 1993
1RCH
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BU of 1rch by Molmil
SOLUTION NMR STRUCTURE OF RIBONUCLEASE HI FROM ESCHERICHIA COLI, 8 STRUCTURES
Descriptor: RIBONUCLEASE HI
Authors:Yamazaki, T, Fujiwara, M, Kato, T, Yamasaki, K, Nagayama, K.
Deposit date:1995-06-23
Release date:1997-02-12
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution Structure of Ribonuclease Hi from Escherichia Coli
Biol.Pharm.Bull., 23, 2000
1RNH
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BU of 1rnh by Molmil
STRUCTURE OF RIBONUCLEASE H PHASED AT 2 ANGSTROMS RESOLUTION BY MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN
Descriptor: RIBONUCLEASE HI, SULFATE ION
Authors:Yang, W, Hendrickson, W.A, Crouch, R.J, Satow, Y.
Deposit date:1990-07-11
Release date:1991-10-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein.
Science, 249, 1990
1RDC
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BU of 1rdc by Molmil
CRYSTAL STRUCTURES OF RIBONUCLEASE HI ACTIVE SITE MUTANTS FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEASE H
Authors:Katayanagi, K, Morikawa, K.
Deposit date:1993-06-23
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of ribonuclease HI active site mutants from Escherichia coli.
J.Biol.Chem., 268, 1993
4WE1
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BU of 4we1 by Molmil
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600)
Descriptor: 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, Gag-Pol polyprotein, MAGNESIUM ION, ...
Authors:Frey, K.M, Anderson, K.S.
Deposit date:2014-09-09
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.491 Å)
Cite:Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers.
Acs Med.Chem.Lett., 5, 2014
5XN2
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BU of 5xn2 by Molmil
HIV-1 reverse transcriptase Q151M:DNA:dGTP ternary complex
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 38-MER DNA aptamer, GLYCEROL, ...
Authors:Yasutake, Y, Tamura, N, Hayashi, H, Maeda, K.
Deposit date:2017-05-17
Release date:2018-02-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.381 Å)
Cite:HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.
Sci Rep, 8, 2018
6HAK
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BU of 6hak by Molmil
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation
Descriptor: Gag-Pol polyprotein, MAGNESIUM ION, RNA (5'-R(P*AP*GP*UP*GP*GP*CP*GP*GP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3'), ...
Authors:Das, K, Martinez, S.E, Arnold, E.
Deposit date:2018-08-07
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation.
Proc.Natl.Acad.Sci.USA, 116, 2019
5OVN
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BU of 5ovn by Molmil
Crystal Structure of FIV Reverse Transcriptase
Descriptor: POL protein
Authors:Galilee, M, Alian, A.
Deposit date:2017-08-29
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.942 Å)
Cite:The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance.
PLoS Pathog., 14, 2018
7KRD
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BU of 7krd by Molmil
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-(3-chloro-5-cyanophenoxy)-3-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenyl sulfurofluoridate (JLJ702)
Descriptor: 4-(3-chloro-5-cyanophenoxy)-3-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenyl sulfurofluoridate, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, ...
Authors:Bertoletti, N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S.
Deposit date:2020-11-19
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead.
Acs Med.Chem.Lett., 12, 2021
1QE1
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BU of 1qe1 by Molmil
CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE
Descriptor: REVERSE TRANSCRIPTASE, SUBUNIT P51, SUBUNIT P66
Authors:Sarafianos, S.G, Das, K, Ding, J, Hughes, S.H, Arnold, E.
Deposit date:1999-07-12
Release date:1999-08-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Proc.Natl.Acad.Sci.USA, 96, 1999
7O24
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BU of 7o24 by Molmil
Structure of the foamy viral protease-reverse transcriptase in complex with dsDNA.
Descriptor: DNA (5'-D(*AP*AP*CP*AP*GP*AP*GP*TP*GP*CP*GP*AP*CP*AP*CP*CP*TP*GP*AP*TP*TP*CP*CP*A)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*CP*TP*G)-3'), Pr125Pol
Authors:Nowotny, M, Czarnocki-Cieciura, M.
Deposit date:2021-03-30
Release date:2021-06-30
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase.
J.Virol., 95, 2021
7O0G
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BU of 7o0g by Molmil
Structure of the foamy viral protease-reverse transcriptase in complex with RNA/DNA hybrid.
Descriptor: DNA (5'-D(*CP*CP*TP*CP*TP*CP*CP*TP*GP*GP*AP*CP*AP*AP*G)-3'), Pr125Pol, RNA (5'-R(*UP*UP*CP*UP*UP*GP*UP*CP*CP*AP*GP*GP*AP*GP*AP*GP*G)-3')
Authors:Nowak, E, Nowacka, M, Nowotny, M.
Deposit date:2021-03-26
Release date:2021-06-30
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase.
J.Virol., 95, 2021
1R0A
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BU of 1r0a by Molmil
Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms
Descriptor: 5'-D(*A*TP*GP*CP*AP*TP*CP*GP*GP*CP*GP*CP*TP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*GP*GP*T)-3', 5'-D(*C*CP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*AP*GP*CP*GP*CP*CP*GP*(2DA))-3', GLYCEROL, ...
Authors:Tuske, S, Ding, J, Arnold, E.
Deposit date:2003-09-19
Release date:2004-08-03
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA.
J.Virol., 78, 2004
4ZHR
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BU of 4zhr by Molmil
Structure of HIV-1 RT Q151M mutant
Descriptor: RT p51 subunit, RT p66 subunit
Authors:Nakamura, A, Tamura, N, Yasutake, Y.
Deposit date:2015-04-27
Release date:2015-11-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase.
Acta Crystallogr.,Sect.F, 71, 2015
7DBN
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BU of 7dbn by Molmil
HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/M184V/F160M:DNA:dCTP ternary complex
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA/RNA (38-MER), GLYCEROL, ...
Authors:Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K.
Deposit date:2020-10-21
Release date:2021-08-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations.
J.Virol., 95, 2021
7DBM
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BU of 7dbm by Molmil
HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/M184V:DNA:dGTP ternary complex
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA/RNA (38-MER), GLYCEROL, ...
Authors:Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K.
Deposit date:2020-10-21
Release date:2021-08-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations.
J.Virol., 95, 2021
7AII
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BU of 7aii by Molmil
HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR WITH BOUND MANGANESE
Descriptor: DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), Gag-Pol polyprotein, ...
Authors:Gu, W, Martinez, S.E, Nguyen, H, Xu, H, Herdewijn, P, de Jonghe, S, Das, K.
Deposit date:2020-09-27
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues.
J.Med.Chem., 64, 2021
7AHX
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BU of 7ahx by Molmil
HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND D-ASPARTATE TENOFOVIR WITH BOUND MANGANESE
Descriptor: D-Aspartate Tenofovir, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(*TP*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ...
Authors:Gu, W, Martinez, S.E, Nguyen, H, Xu, H, Herdewijn, P, de Jonghe, S, Das, K.
Deposit date:2020-09-25
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues.
J.Med.Chem., 64, 2021
6P2G
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BU of 6p2g by Molmil
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and D-ddCTP
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA Primer 20-mer, DNA template 27-mer, ...
Authors:Bertoletti, N, Anderson, K.S.
Deposit date:2019-05-21
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Protein Sci., 28, 2019
5K14
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HIV-1 Reverse Transcriptase in complex with a 2,6-difluorophenyl DAPY analog
Descriptor: 4-{[4-(2,6-difluoro-4-methoxybenzene-1-carbonyl)pyrimidin-2-yl]amino}benzonitrile, HIV-1 reverse transcriptase (isolate LW123), HIV-1 reverse transcriptase(isolate HXB2)
Authors:Lansdon, E.B.
Deposit date:2016-05-17
Release date:2016-06-29
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1.
Eur.J.Med.Chem., 122, 2016

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