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1IG8
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BU of 1ig8 by Molmil
Crystal Structure of Yeast Hexokinase PII with the correct amino acid sequence
Descriptor: SULFATE ION, hexokinase PII
Authors:Kuser, P.R, Krauchenco, S, Antunes, O.A, Polikarpov, I.
Deposit date:2001-04-17
Release date:2001-05-02
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action.
J.Biol.Chem., 275, 2000
4NO7
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BU of 4no7 by Molmil
Human Glucokinase in complex with a nanomolar activator.
Descriptor: (2R)-2-[3-chloro-4-(methylsulfonyl)phenyl]-3-[(1R)-3-oxocyclopentyl]-N-(pyrazin-2-yl)propanamide, Glucokinase, alpha-D-glucopyranose
Authors:Petit, P, Ferry, G, Antoine, M, Boutin, J.A, Kotschy, A, Perron-Sierra, F, Mamelli, L, Vuillard, L.
Deposit date:2013-11-19
Release date:2014-10-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The active conformation of human glucokinase is not altered by allosteric activators.
Acta Crystallogr. D Biol. Crystallogr., 67, 2011
5HEX
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BU of 5hex by Molmil
Crystal Structure of Human Hexokinase 2 with cmpd 30, a 2-amino-6-benzenesulfonamide glucosamine
Descriptor: 2-[(3-bromobenzene-1-carbonyl)amino]-6-{[(4-carboxy-5-methylfuran-2-yl)sulfonyl]amino}-2,6-dideoxy-alpha-D-glucopyranos e, Hexokinase-2
Authors:Campobasso, N, Zhao, B, Smallwood, A.
Deposit date:2016-01-06
Release date:2016-03-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.734 Å)
Cite:Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
Acs Med.Chem.Lett., 7, 2016
3A0I
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BU of 3a0i by Molmil
Human glucokinase in complex with a synthetic activator
Descriptor: 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide, Glucokinase, SODIUM ION, ...
Authors:Kamata, K, Mitsuya, M.
Deposit date:2009-03-19
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators
Bioorg.Med.Chem.Lett., 19, 2009
1HKB
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BU of 1hkb by Molmil
CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE
Descriptor: 6-O-phosphono-alpha-D-glucopyranose, CALCIUM ION, D-GLUCOSE 6-PHOSPHOTRANSFERASE, ...
Authors:Aleshin, A.E, Zeng, C, Burenkov, G.P, Bartunik, H.D, Fromm, H.J, Honzatko, R.B.
Deposit date:1997-12-01
Release date:1998-06-03
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.
Structure, 6, 1998
5HFU
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BU of 5hfu by Molmil
Crystal Structure of Human Hexokinase 2 with cmpd 27, a 2-amido-6-benzenesulfonamide glucosamine
Descriptor: Hexokinase-2, ~{N}-[(2~{S},3~{R},4~{R},5~{S},6~{R})-6-[[(4-cyanophenyl)sulfonylamino]methyl]-2,4,5-tris(oxidanyl)oxan-3-yl]-3-phenyl-benzamide
Authors:Campobasso, N, Zhao, B, Smallwood, A.
Deposit date:2016-01-07
Release date:2016-03-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.923 Å)
Cite:Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
Acs Med.Chem.Lett., 7, 2016
1HKC
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BU of 1hkc by Molmil
RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE
Descriptor: D-GLUCOSE 6-PHOSPHOTRANSFERASE, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Aleshin, A.E, Honzatko, R.B.
Deposit date:1998-07-01
Release date:1998-11-11
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.
J.Mol.Biol., 282, 1998
5HG1
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BU of 5hg1 by Molmil
Crystal Structure of Human Hexokinase 2 with cmpd 1, a C-2-substituted glucosamine
Descriptor: 2-deoxy-2-{[(2E)-3-(3,4-dichlorophenyl)prop-2-enoyl]amino}-alpha-D-glucopyranose, 6-O-phosphono-beta-D-glucopyranose, CITRATE ANION, ...
Authors:Campobasso, N, Zhao, B, Smallwood, A.
Deposit date:2016-01-07
Release date:2016-03-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
Acs Med.Chem.Lett., 7, 2016
3F9M
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BU of 3f9m by Molmil
Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap
Descriptor: 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE, Glucokinase, alpha-D-glucopyranose
Authors:Petit, P, Gluais, L, Lagarde, A, Vuillard, L, Boutin, J.A, Ferry, G.
Deposit date:2008-11-14
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The active conformation of human glucokinase is not altered by allosteric activators
Acta Crystallogr.,Sect.D, 67, 2011
3B8A
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BU of 3b8a by Molmil
Crystal structure of yeast hexokinase PI in complex with glucose
Descriptor: Hexokinase-1, SULFATE ION, beta-D-glucopyranose
Authors:Kuser, P, Cupri, F, Bleicher, L, Polikarpov, I.
Deposit date:2007-10-31
Release date:2008-02-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of yeast hexokinase PI in complex with glucose: A classical "induced fit" example revised.
Proteins, 72, 2008
3FGU
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BU of 3fgu by Molmil
Catalytic complex of Human Glucokinase
Descriptor: Glucokinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Petit, P, Lagarde, A, Boutin, J.A, Ferry, G, Vuillard, L.
Deposit date:2008-12-08
Release date:2009-12-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The active conformation of human glucokinase is not altered by allosteric activators
Acta Crystallogr.,Sect.D, 67, 2011
3FR0
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BU of 3fr0 by Molmil
Human glucokinase in complex with 2-amino benzamide activator
Descriptor: 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, Glucokinase, SODIUM ION, ...
Authors:Kamata, K.
Deposit date:2009-01-08
Release date:2009-02-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators
Bioorg.Med.Chem.Lett., 19, 2009
4QS7
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BU of 4qs7 by Molmil
Arabidopsis Hexokinase 1 (AtHXK1) structure in glucose-bound form
Descriptor: Hexokinase-1, beta-D-glucopyranose
Authors:Feng, J, Zhao, S, Liu, L.
Deposit date:2014-07-03
Release date:2015-02-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Biochemical and structural study of Arabidopsis hexokinase 1
Acta Crystallogr.,Sect.D, 71, 2015
4QS9
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Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form
Descriptor: Hexokinase-1, beta-D-glucopyranose
Authors:Feng, J, Zhao, S, Liu, L.
Deposit date:2014-07-03
Release date:2015-02-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Biochemical and structural study of Arabidopsis hexokinase 1
Acta Crystallogr.,Sect.D, 71, 2015
4QS8
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BU of 4qs8 by Molmil
Arabidopsis Hexokinase 1 (AtHXK1) structure in ligand-free form
Descriptor: Hexokinase-1
Authors:Feng, J, Zhao, S, Liu, L.
Deposit date:2014-07-03
Release date:2015-02-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Biochemical and structural study of Arabidopsis hexokinase 1
Acta Crystallogr.,Sect.D, 71, 2015
4RCH
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BU of 4rch by Molmil
Discovery of 2-Pyridyl Ureas as Glucokinase Activators
Descriptor: 1-{3-[(2-ethylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}-3-methylurea, Glucokinase, alpha-D-glucopyranose
Authors:Voegtli, W, Vigers, G.P.A.
Deposit date:2014-09-16
Release date:2014-10-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of 2-pyridylureas as glucokinase activators.
J.Med.Chem., 57, 2014
3S41
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BU of 3s41 by Molmil
Glucokinase in complex with activator and glucose
Descriptor: Glucokinase, N,N-dimethyl-5-({2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl}oxy)pyrimidine-2-carboxamide, SODIUM ION, ...
Authors:Liu, S.
Deposit date:2011-05-18
Release date:2011-09-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus
MEDCHEMCOMM, 2, 2011
3VF6
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BU of 3vf6 by Molmil
Glucokinase in complex with glucose and activator
Descriptor: 6-({(2S)-3-cyclopentyl-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propanoyl}amino)pyridine-3-carboxylic acid, Glucokinase, SODIUM ION, ...
Authors:Liu, S.
Deposit date:2012-01-09
Release date:2012-02-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.
J.Biol.Chem., 287, 2012
3VEY
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BU of 3vey by Molmil
glucokinase in complex with glucose and ATPgS
Descriptor: 6-methoxy-N-(1-methyl-1H-pyrazol-3-yl)quinazolin-4-amine, Glucokinase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Liu, S.
Deposit date:2012-01-09
Release date:2012-02-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.
J.Biol.Chem., 287, 2012
3W0L
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BU of 3w0l by Molmil
The crystal structure of Xenopus Glucokinase and Glucokinase Regulatory Protein complex
Descriptor: FRUCTOSE -6-PHOSPHATE, Glucokinase, Glucokinase regulatory protein, ...
Authors:Choi, J.M, Seo, M.H, Kyeong, H.H, Kim, E, Kim, H.S.
Deposit date:2012-10-31
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase
Proc.Natl.Acad.Sci.USA, 110, 2013
3VEV
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BU of 3vev by Molmil
Glucokinase in complex with an activator and glucose
Descriptor: (2S)-3-cyclopentyl-N-(5-methylpyridin-2-yl)-2-[2-oxo-4-(trifluoromethyl)pyridin-1(2H)-yl]propanamide, Glucokinase, SODIUM ION, ...
Authors:Liu, S.
Deposit date:2012-01-09
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.
J.Biol.Chem., 287, 2012
3GOI
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BU of 3goi by Molmil
Human glucokinase in complex with a synthetic activator
Descriptor: 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, Glucokinase, alpha-D-glucopyranose
Authors:Kamata, K, Mitsuya, M.
Deposit date:2009-03-19
Release date:2009-04-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators
Bioorg.Med.Chem.Lett., 19, 2009
6JJ7
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BU of 6jj7 by Molmil
Crystal structure of OsHXK6-Glc complex
Descriptor: Rice hexokinase 6, beta-D-glucopyranose
Authors:He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L.
Deposit date:2019-02-25
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of OsHXK6-Glc complex
To Be Published
6JJ4
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Crystal structure of OsHXK6-apo form
Descriptor: Hexokinase-6
Authors:He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L.
Deposit date:2019-02-25
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of OsHXK6-apo
To Be Published
6JJ9
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Crystal structure of OsHXK6-Glc-ATP-Mg2+ complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Hexokinase-6, MAGNESIUM ION, ...
Authors:He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L.
Deposit date:2019-02-25
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of OsHXK6-Glc-ATP-Mg2+ complex
To Be Published

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