5FF8
| TDG enzyme-product complex | Descriptor: | DNA, G/T mismatch-specific thymine DNA glycosylase | Authors: | Pozharski, E, Malik, S.S, Drohat, A.C. | Deposit date: | 2015-12-18 | Release date: | 2016-09-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues. Nucleic Acids Res., 44, 2016
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4UQM
| Crystal structure determination of uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans in complex with DNA - new insights into the role of the Leucine-loop for damage recognition and repair | Descriptor: | 5'-D(*CP*CP*TP*AP*TP*CP*CP*AP*AAB*GP*TP*CP*TP*CP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*GP*AP*CP*AP*TP*GP*GP*AP*CP*AP*G)-3', CHLORIDE ION, ... | Authors: | Pedersen, H.L, Johnson, K.A, McVey, C.E, Leiros, I, Moe, E. | Deposit date: | 2014-06-24 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA. Acta Crystallogr. D Biol. Crystallogr., 71, 2015
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1AKZ
| HUMAN URACIL-DNA GLYCOSYLASE | Descriptor: | URACIL-DNA GLYCOSYLASE | Authors: | Tainer, J.A, Mol, C.D. | Deposit date: | 1997-05-27 | Release date: | 1997-08-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. Embo J., 17, 1998
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3IKB
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5JXY
| Enzyme-substrate complex of TDG catalytic domain bound to a G/U analog | Descriptor: | DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase | Authors: | Pidugu, L.S, Pozharski, E, Malik, S.S, Drohat, A.C. | Deposit date: | 2016-05-13 | Release date: | 2016-09-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues. Nucleic Acids Res., 44, 2016
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4SKN
| A NUCLEOTIDE-FLIPPING MECHANISM FROM THE STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO DNA | Descriptor: | DNA (5'-D(*AP*AP*AP*GP*CP*CP*GP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*(D1P)P*GP*GP*CP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE), ... | Authors: | Slupphaug, G, Mol, C.D, Kavli, B, Arvai, A.S, Krokan, H.E, Tainer, J.A. | Deposit date: | 1999-02-20 | Release date: | 1999-02-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature, 384, 1996
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5T2W
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3A7N
| Crystal structure of uracil-DNA glycosylase from Mycobacterium tuberculosis | Descriptor: | CITRATE ANION, Uracil-DNA glycosylase | Authors: | Kaushal, P.S, Talawar, R.K, Varshney, U, Vijayan, M. | Deposit date: | 2009-09-29 | Release date: | 2010-08-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of uracil-DNA glycosylase from Mycobacterium tuberculosis: insights into interactions with ligands Acta Crystallogr.,Sect.F, 66, 2010
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4JGC
| Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC) | Descriptor: | 4-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid, G/T mismatch-specific thymine DNA glycosylase, oligonucleotide, ... | Authors: | Hashimoto, H, Zhang, X, Cheng, X. | Deposit date: | 2013-02-28 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.582 Å) | Cite: | Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. Dna Repair, 12, 2013
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5EUG
| CRYSTALLOGRAPHIC AND ENZYMATIC STUDIES OF AN ACTIVE SITE VARIANT H187Q OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE: CRYSTAL STRUCTURES OF MUTANT H187Q AND ITS URACIL COMPLEX | Descriptor: | PROTEIN (GLYCOSYLASE), URACIL | Authors: | Xiao, G, Tordova, M, Drohat, A.C, Jagadeesh, J, Stivers, J.T, Gilliland, G.L. | Deposit date: | 1998-12-27 | Release date: | 1999-07-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited. Proteins, 35, 1999
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5CYS
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4EUG
| Crystallographic and Enzymatic Studies of an Active Site Variant H187Q of Escherichia Coli Uracil DNA Glycosylase: Crystal Structures of Mutant H187Q and its Uracil Complex | Descriptor: | PROTEIN (GLYCOSYLASE) | Authors: | Xiao, G, Tordova, M, Drohat, A.C, Jagadeesh, J, Stivers, J.T, Gilliland, G.L. | Deposit date: | 1998-12-27 | Release date: | 1999-07-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187. Biochemistry, 38, 1999
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4FNC
| Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU) | Descriptor: | 5-HYDROXYMETHYL URACIL, DNA (28-MER), DNA (29-MER), ... | Authors: | Hashimoto, H, Hong, S, Bhagwat, A.S, Zhang, X, Cheng, X. | Deposit date: | 2012-06-19 | Release date: | 2012-09-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.493 Å) | Cite: | Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Res., 40, 2012
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2SSP
| LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA | Descriptor: | DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*TP*(AAB)P*AP*TP*CP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE) | Authors: | Parikh, S.S, Mol, C.D, Slupphaug, G, Bharati, S, Krokan, H.E, Tainer, J.A. | Deposit date: | 1999-04-28 | Release date: | 1999-05-06 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. EMBO J., 17, 1998
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1VK2
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1YUO
| Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG)from atlantic cod (Gadus morhua) | Descriptor: | Uracil-DNA glycosylase | Authors: | Moe, E, Leiros, I, Riise, E.K, Olufsen, M, Lanes, O, Smalas, A.O, Willassen, N.P. | Deposit date: | 2005-02-14 | Release date: | 2005-03-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua) J.Mol.Biol., 343, 2004
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5NNH
| KSHV uracil-DNA glycosylase, apo form | Descriptor: | SULFATE ION, Uracil-DNA glycosylase | Authors: | Earl, C, Bagneris, C, Cole, A.R, Barrett, T, Savva, R. | Deposit date: | 2017-04-09 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping. Nucleic Acids Res., 46, 2018
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5NN7
| KSHV uracil-DNA glycosylase, apo form | Descriptor: | Uracil-DNA glycosylase | Authors: | Earl, C, Bagneris, C, Cole, A.R, Barrett, T, Savva, R. | Deposit date: | 2017-04-08 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping. Nucleic Acids Res., 46, 2018
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5NNU
| KSHV uracil-DNA glycosylase, product complex with dsDNA exhibiting duplex nucleotide flipping | Descriptor: | DNA, DNA containing an abasic site, Uracil-DNA glycosylase | Authors: | Earl, C, Bagneris, C, Barrett, T, Savva, R. | Deposit date: | 2017-04-10 | Release date: | 2018-03-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping. Nucleic Acids Res., 46, 2018
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2OXM
| Crystal structure of a UNG2/modified DNA complex that represent a stabilized short-lived extrahelical state in ezymatic DNA base flipping | Descriptor: | DNA (5'-D(*AP*AP*AP*GP*AP*TP*(4MF)P*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*AP*TP*CP*TP*T)-3'), Uracil-DNA glycosylase | Authors: | Bianchet, M.A, Krosky, D.J, Stivers, J.T, Amzel, L.M. | Deposit date: | 2007-02-20 | Release date: | 2007-10-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. Nature, 449, 2007
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2OYT
| Crystal Structure of UNG2/DNA(TM) | Descriptor: | DNA strand1, DNA strand2, Uracil-DNA glycosylase | Authors: | Bianchet, M.A, Krosky, D.J, Stivers, J.T, Amzel, L.M. | Deposit date: | 2007-02-22 | Release date: | 2007-10-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. Nature, 449, 2007
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2RBA
| Structure of Human Thymine DNA Glycosylase Bound to Abasic and Undamaged DNA | Descriptor: | DNA (5'-D(*DCP*DAP*DGP*DCP*DTP*DCP*DTP*DGP*DTP*DAP*DCP*DGP*DTP*DGP*DAP*DGP*DCP*DAP*DGP*DTP*DGP*DGP*DA)-3'), DNA (5'-D(*DCP*DCP*DAP*DCP*DTP*DGP*DCP*DTP*DCP*DAP*(3DR)P*DGP*DTP*DAP*DCP*DAP*DGP*DAP*DGP*DCP*DTP*DGP*DT)-3'), G/T mismatch-specific thymine DNA glycosylase | Authors: | Maiti, A, Pozharski, E, Drohat, A.C. | Deposit date: | 2007-09-18 | Release date: | 2008-06-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition. Proc.Natl.Acad.Sci.Usa, 105, 2008
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2HXM
| Complex of UNG2 and a small Molecule synthetic Inhibitor | Descriptor: | 4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID, Uracil-DNA glycosylase | Authors: | Bianchet, M.A, Krosky, D.J, Ghung, S, Seiple, L, Amzel, L.M, Stivers, J.T. | Deposit date: | 2006-08-03 | Release date: | 2006-12-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Mimicking damaged DNA with a small molecule inhibitor of human UNG2. Nucleic Acids Res., 34, 2006
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2JHQ
| Crystal structure of Uracil DNA-glycosylase from Vibrio cholerae | Descriptor: | CHLORIDE ION, URACIL DNA-GLYCOSYLASE | Authors: | Raeder, I.L.U, Moe, E, Willassen, N.P, Smalas, A.O, Leiros, I. | Deposit date: | 2007-02-23 | Release date: | 2008-06-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of Uracil-DNA N-Glycosylase (Ung) from Vibrio Cholerae. Mapping Temperature Adaptation Through Structural and Mutational Analysis. Acta Crystallogr.,Sect.F, 66, 2010
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2L3F
| Solution NMR Structure of a putative Uracil DNA glycosylase from Methanosarcina acetivorans, Northeast Structural Genomics Consortium Target MvR76 | Descriptor: | Uncharacterized protein | Authors: | Aramini, J.M, Hamilton, K, Ciccosanti, C.T, Wang, H, Lee, H.W, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-09-13 | Release date: | 2010-10-20 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of a putative Uracil DNA glycosylase from Methanosarcina acetivorans, Northeast Structural Genomics Consortium Target MvR76 To be Published
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