2HXM

Complex of UNG2 and a small Molecule synthetic Inhibitor

Summary for 2HXM

Entry DOI	10.2210/pdb2hxm/pdb
Descriptor	Uracil-DNA glycosylase, 4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID (3 entities in total)
Functional Keywords	dna repair, uracil, uracil dna glycosylase, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Mitochondrion. Isoform 2: Nucleus: P13051
Total number of polymer chains	1
Total formula weight	25890.43
Authors	Bianchet, M.A.,Krosky, D.J.,Ghung, S.,Seiple, L.,Amzel, L.M.,Stivers, J.T. (deposition date: 2006-08-03, release date: 2006-12-05, Last modification date: 2023-08-30)
Primary citation	Krosky, D.J.,Bianchet, M.A.,Seiple, L.,Chung, S.,Amzel, L.M.,Stivers, J.T. Mimicking damaged DNA with a small molecule inhibitor of human UNG2. Nucleic Acids Res., 34:5872-5879, 2006 Cited by PubMed: 17062624 DOI: 10.1093/nar/gkl747 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation