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9DDY
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BU of 9ddy by Molmil
The Crystal Structure of Geranyltranstransferase from Streptococcus pneumoniae TIGR4
Descriptor: GLYCEROL, Geranyltranstransferase
Authors:Kim, Y, Tan, A, Endres, M, Tan, K, Joachimik, A, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2024-08-28
Release date:2024-09-18
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:The Crystal Structure of Geranyltranstransferase from Streptococcus pneumoniae TIGR4
To Be Published
3CP6
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BU of 3cp6 by Molmil
Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor
Descriptor: (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), Farnesyl pyrophosphate synthetase, MAGNESIUM ION
Authors:Pilka, E.S, Dunford, J.E, Guo, K, Pike, A.C.W, von Delft, F, Barnett, B.L, Ebetino, F.H, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Russell, R.G.G, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor.
To be Published
4UMJ
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BU of 4umj by Molmil
Native structure of Farnesyl Pyrophosphate Synthase from Pseudomonas aeruginosa PA01, with bound ibandronic acid molecules.
Descriptor: GERANYLTRANSTRANSFERASE, IBANDRONATE, MAGNESIUM ION
Authors:Schmidberger, J.W, Schnell, R, Schneider, G.
Deposit date:2014-05-18
Release date:2015-03-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Characterization of Substrate and Inhibitor Binding to Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa.
Acta Crystallogr.,Sect.D, 71, 2015
4WK5
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BU of 4wk5 by Molmil
Crystal structure of a Isoprenoid Synthase family member from Thermotoga neapolitana DSM 4359, target EFI-509458
Descriptor: Geranyltranstransferase
Authors:Toro, R, Bhosle, R, Vetting, M.W, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Poulter, C.D, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2014-10-01
Release date:2014-11-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of a Isoprenoid Synthase family member from Thermotoga neapolitana DSM 4359, target EFI-509458
To be published
1FPS
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BU of 1fps by Molmil
CRYSTAL STRUCTURE OF RECOMBINANT FARNESYL DIPHOSPHATE SYNTHASE AT 2.6 ANGSTROMS RESOLUTION
Descriptor: FARNESYL DIPHOSPHATE SYNTHASE
Authors:Tarshis, L.C, Yan, M, Poulter, C.D, Sacchettini, J.C.
Deposit date:1994-06-30
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.
Biochemistry, 33, 1994
2VF6
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BU of 2vf6 by Molmil
Human FDPS synthase in complex with minodronate
Descriptor: (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID), FARNESYL PYROPHOSPHATE SYNTHETASE, MAGNESIUM ION
Authors:Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M.
Deposit date:2007-10-31
Release date:2007-11-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Fdps Synthase in Complex with Novel Inhibitor
To be Published
8WD5
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BU of 8wd5 by Molmil
Crystal structure of farnesyl diphosphate synthase FPPS1 from silkworm, Bombyx mori
Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL
Authors:Guo, P.C, Fang, H.
Deposit date:2023-09-14
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Insights into the Substrate Binding of Farnesyl Diphosphate Synthase FPPS1 from Silkworm, Bombyx mori.
J.Agric.Food Chem., 72, 2024
6W7I
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BU of 6w7i by Molmil
LmFPPS mutant T164W in complex with 476A, IPP & Ca
Descriptor: 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ACETATE ION, CALCIUM ION, ...
Authors:Maheshwari, S, Kim, Y.S, Aripirala, S, Gabelli, S.B.
Deposit date:2020-03-19
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
Biochemistry, 59, 2020
6G31
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BU of 6g31 by Molmil
Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y bound to zoledronate
Descriptor: Geranylgeranyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID
Authors:Lisnyansky, M, Kapelushnik, N, Ben-Bassat, A, Marom, M, Loewenstein, A, Khananshvili, D, Giladi, M, Haitin, Y.
Deposit date:2018-03-24
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures.
Mol. Pharmacol., 94, 2018
6WW1
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BU of 6ww1 by Molmil
Crystal structure of the LmFPPS mutant E97Y
Descriptor: 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ACETATE ION, CALCIUM ION, ...
Authors:Maheshwari, S, Kim, Y.S, Gabelli, S.B.
Deposit date:2020-05-07
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
Biochemistry, 59, 2020
6G32
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BU of 6g32 by Molmil
Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y
Descriptor: GLYCEROL, Geranylgeranyl pyrophosphate synthase
Authors:Lisnyansky, M, Kapelushnik, N, Ben-Bassat, A, Marom, M, Loewenstein, A, Khananshvili, D, Giladi, M, Haitin, Y.
Deposit date:2018-03-24
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.281 Å)
Cite:Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures.
Mol. Pharmacol., 94, 2018
6KD7
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BU of 6kd7 by Molmil
Crystal structure of geranylgeranyl pyrophosphate synthase
Descriptor: GLYCEROL, MAGNESIUM ION, PYROPHOSPHATE, ...
Authors:Kim, S, Kim, K.-J.
Deposit date:2019-07-01
Release date:2019-09-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of geranylgeranyl pyrophosphate synthase (crtE) from Nonlabens dokdonensis DSW-6.
Biochem.Biophys.Res.Commun., 518, 2019
6N82
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BU of 6n82 by Molmil
Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Farnesyl pyrophosphate synthase, ...
Authors:Park, J, Schilling, M.A, Berghuis, A.M.
Deposit date:2018-11-28
Release date:2019-11-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
4XQR
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BU of 4xqr by Molmil
Crystal structure of unliganded human FPPS at 2.15 angstrom resolution
Descriptor: Farnesyl pyrophosphate synthase, PHOSPHATE ION
Authors:Park, J, Berghuis, A.M.
Deposit date:2015-01-20
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of unliganded human FPPS at 2.15 angstrom resolution
To Be Published
5AFX
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BU of 5afx by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1238
Descriptor: FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, [1-hydroxy-2-(1-nonyl-1H-3lambda~5~-imidazol-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
Authors:Yang, G, Oldfield, E, No, J.H.
Deposit date:2015-01-27
Release date:2015-10-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation.
Antimicrob.Agents Chemother., 59, 2015
5AHU
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BU of 5ahu by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1326
Descriptor: FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE, MAGNESIUM ION, ...
Authors:Yang, G, Oldfield, E, No, J.H.
Deposit date:2015-02-09
Release date:2015-10-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation.
Antimicrob.Agents Chemother., 59, 2015
5AEL
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BU of 5ael by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-597
Descriptor: FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, {2-[3-(hex-1-yn-1-yl)pyridinium-1-yl]ethane-1,1-diyl}bis(phosphonate)
Authors:Yang, G, Oldfield, E, No, J.H.
Deposit date:2014-12-26
Release date:2015-10-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation.
Antimicrob.Agents Chemother., 59, 2015
5XN6
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BU of 5xn6 by Molmil
Heterodimer crystal structure of geranylgeranyl diphosphate synthases 1 with GGPPS Recruiting Protein(OsGRP) from Oryza sativa
Descriptor: Os02g0668100 protein, Os07g0580900 protein
Authors:Wang, C, Zhou, F, Lu, S, Zhang, P.
Deposit date:2017-05-18
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4XQT
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BU of 4xqt by Molmil
Crystal structure of human FPPS in complex with three magnesium ions
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION
Authors:Park, J, Berghuis, A.M.
Deposit date:2015-01-20
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human FPPS in complex with three magnesium ions
To Be Published
4XQS
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Crystal structure of human FPPS in complex with one magnesium ion
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION
Authors:Park, J, Berghuis, A.M.
Deposit date:2015-01-20
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human FPPS in complex with one magnesium ion
To Be Published
5XN5
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BU of 5xn5 by Molmil
Homo-dimer crystal structure of geranylgeranyl diphosphate synthases 1 from Oryza sativa
Descriptor: Os07g0580900 protein
Authors:Wang, C, Zhou, F, Lu, S, Zhang, P.
Deposit date:2017-05-18
Release date:2017-06-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5YGI
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BU of 5ygi by Molmil
Crystal structure of human FPPS in complex with an inhibitor THZ93
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Li, X.
Deposit date:2017-09-23
Release date:2018-09-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.177 Å)
Cite:The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell, 175, 2018
1RQI
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BU of 1rqi by Molmil
Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Dimethylallyl S-Thiolodiphosphate
Descriptor: DIMETHYLALLYL S-THIOLODIPHOSPHATE, DIPHOSPHATE, Geranyltranstransferase, ...
Authors:Hosfield, D.J, Zhang, Y, Dougan, D.R, Brooun, A, Tari, L.W, Swanson, R.V, Finn, J.
Deposit date:2003-12-05
Release date:2004-03-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
J.Biol.Chem., 279, 2004
1RTR
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BU of 1rtr by Molmil
Crystal Structure of S. Aureus Farnesyl Pyrophosphate Synthase
Descriptor: geranyltranstransferase
Authors:Hosfield, D.J, Zhang, Y, Dougan, D.R, Brooun, A, Tari, L.W, Swanson, R.V, Finn, J.
Deposit date:2003-12-10
Release date:2004-03-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
J.Mol.Biol., 279, 2004
1RQJ
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Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Risedronate
Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranyltranstransferase, ...
Authors:Hosfield, D.J, Zhang, Y, Dougan, D.R, Brooun, A, Tari, L.W, Swanson, R.V, Finn, J.
Deposit date:2003-12-05
Release date:2004-03-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
J.Biol.Chem., 279, 2004

225399

数据于2024-09-25公开中

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