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6VJC
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BU of 6vjc by Molmil
LmFPPS mutant T164Y in complex with 476A, IPP & Ca
Descriptor: 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ACETATE ION, CALCIUM ION, ...
Authors:Maheshwari, S, Kim, Y.S, Aripirala, S, Gabelli, S.B.
Deposit date:2020-01-15
Release date:2020-11-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
Biochemistry, 59, 2020
5XN6
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BU of 5xn6 by Molmil
Heterodimer crystal structure of geranylgeranyl diphosphate synthases 1 with GGPPS Recruiting Protein(OsGRP) from Oryza sativa
Descriptor: Os02g0668100 protein, Os07g0580900 protein
Authors:Wang, C, Zhou, F, Lu, S, Zhang, P.
Deposit date:2017-05-18
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8WD5
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BU of 8wd5 by Molmil
Crystal structure of farnesyl diphosphate synthase FPPS1 from silkworm, Bombyx mori
Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL
Authors:Guo, P.C, Fang, H.
Deposit date:2023-09-14
Release date:2024-05-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Insights into the Substrate Binding of Farnesyl Diphosphate Synthase FPPS1 from Silkworm, Bombyx mori.
J.Agric.Food Chem., 72, 2024
4WK5
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BU of 4wk5 by Molmil
Crystal structure of a Isoprenoid Synthase family member from Thermotoga neapolitana DSM 4359, target EFI-509458
Descriptor: Geranyltranstransferase
Authors:Toro, R, Bhosle, R, Vetting, M.W, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Poulter, C.D, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2014-10-01
Release date:2014-11-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of a Isoprenoid Synthase family member from Thermotoga neapolitana DSM 4359, target EFI-509458
To be published
8HDL
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BU of 8hdl by Molmil
Crystal structure of ASFV trans geranylgeranyl diphosphate synthase B318L
Descriptor: Trans-prenyltransferase
Authors:Zhao, H.F.
Deposit date:2022-11-04
Release date:2023-09-06
Method:X-RAY DIFFRACTION (3.198 Å)
Cite:Exploring AlphaFold2's Performance on Predicting Amino Acid Side-Chain Conformations and Its Utility in Crystal Structure Determination of B318L Protein.
Int J Mol Sci, 24, 2023
6KD7
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BU of 6kd7 by Molmil
Crystal structure of geranylgeranyl pyrophosphate synthase
Descriptor: GLYCEROL, MAGNESIUM ION, PYROPHOSPHATE, ...
Authors:Kim, S, Kim, K.-J.
Deposit date:2019-07-01
Release date:2019-09-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of geranylgeranyl pyrophosphate synthase (crtE) from Nonlabens dokdonensis DSW-6.
Biochem.Biophys.Res.Commun., 518, 2019
1FPS
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BU of 1fps by Molmil
CRYSTAL STRUCTURE OF RECOMBINANT FARNESYL DIPHOSPHATE SYNTHASE AT 2.6 ANGSTROMS RESOLUTION
Descriptor: FARNESYL DIPHOSPHATE SYNTHASE
Authors:Tarshis, L.C, Yan, M, Poulter, C.D, Sacchettini, J.C.
Deposit date:1994-06-30
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.
Biochemistry, 33, 1994
6W7I
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BU of 6w7i by Molmil
LmFPPS mutant T164W in complex with 476A, IPP & Ca
Descriptor: 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ACETATE ION, CALCIUM ION, ...
Authors:Maheshwari, S, Kim, Y.S, Aripirala, S, Gabelli, S.B.
Deposit date:2020-03-19
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
Biochemistry, 59, 2020
6G31
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BU of 6g31 by Molmil
Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y bound to zoledronate
Descriptor: Geranylgeranyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID
Authors:Lisnyansky, M, Kapelushnik, N, Ben-Bassat, A, Marom, M, Loewenstein, A, Khananshvili, D, Giladi, M, Haitin, Y.
Deposit date:2018-03-24
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures.
Mol. Pharmacol., 94, 2018
6G32
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BU of 6g32 by Molmil
Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y
Descriptor: GLYCEROL, Geranylgeranyl pyrophosphate synthase
Authors:Lisnyansky, M, Kapelushnik, N, Ben-Bassat, A, Marom, M, Loewenstein, A, Khananshvili, D, Giladi, M, Haitin, Y.
Deposit date:2018-03-24
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.281 Å)
Cite:Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures.
Mol. Pharmacol., 94, 2018
6WW1
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BU of 6ww1 by Molmil
Crystal structure of the LmFPPS mutant E97Y
Descriptor: 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ACETATE ION, CALCIUM ION, ...
Authors:Maheshwari, S, Kim, Y.S, Gabelli, S.B.
Deposit date:2020-05-07
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
Biochemistry, 59, 2020
6C57
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BU of 6c57 by Molmil
Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with bisphosphonate inhibitor FV0109
Descriptor: Geranylgeranyl pyrophosphate synthase, {[(2-{3-[(4-fluorobenzene-1-carbonyl)amino]phenyl}thieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid)
Authors:Park, J, Bin, X, Vincent, F, Tsantrizos, Y.S, Berghuis, A.M.
Deposit date:2018-01-15
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
J. Med. Chem., 61, 2018
6C56
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BU of 6c56 by Molmil
Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in its Apo form
Descriptor: Geranylgeranyl pyrophosphate synthase, {[(2-phenylthieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid)
Authors:Park, J, Ta, V, Tsantrizos, Y.S, Berghuis, A.M.
Deposit date:2018-01-15
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
J. Med. Chem., 61, 2018
3TC1
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BU of 3tc1 by Molmil
Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori
Descriptor: MAGNESIUM ION, Octaprenyl Pyrophosphate Synthase
Authors:Zhang, J.Y, Zhang, X.L, Li, D.F, Zou, Q.M, Wang, D.C.
Deposit date:2011-08-08
Release date:2011-08-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori
To be Published
4XQR
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BU of 4xqr by Molmil
Crystal structure of unliganded human FPPS at 2.15 angstrom resolution
Descriptor: Farnesyl pyrophosphate synthase, PHOSPHATE ION
Authors:Park, J, Berghuis, A.M.
Deposit date:2015-01-20
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of unliganded human FPPS at 2.15 angstrom resolution
To Be Published
3RYE
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BU of 3rye by Molmil
Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate
Descriptor: 3-(2-hydroxy-2,2-diphosphonoethyl)-1-methylpyridinium, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ...
Authors:Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M.
Deposit date:2011-05-11
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate
To be Published
3RYW
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BU of 3ryw by Molmil
Crystal structure of P. vivax geranylgeranyl diphosphate synthase complexed with BPH-811
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ...
Authors:No, J.H, Liu, Y.-L, Zhang, Y, Oldfield, E.
Deposit date:2011-05-11
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.
Proc.Natl.Acad.Sci.USA, 109, 2012
4XQT
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BU of 4xqt by Molmil
Crystal structure of human FPPS in complex with three magnesium ions
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION
Authors:Park, J, Berghuis, A.M.
Deposit date:2015-01-20
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human FPPS in complex with three magnesium ions
To Be Published
3S4J
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BU of 3s4j by Molmil
Human FDPS Synthase in Complex with a Rigid Analog of Risedronate
Descriptor: 6,7-dihydro-5H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), Farnesyl pyrophosphate synthase, MAGNESIUM ION, ...
Authors:Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M.
Deposit date:2011-05-19
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Human FDPS Synthase in Complex with a Rigid Analog of Risedronate
To be Published
4XQS
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BU of 4xqs by Molmil
Crystal structure of human FPPS in complex with one magnesium ion
Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION
Authors:Park, J, Berghuis, A.M.
Deposit date:2015-01-20
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human FPPS in complex with one magnesium ion
To Be Published
3TS7
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BU of 3ts7 by Molmil
CRYSTAL STRUCTURE OF FARNESYL DIPHOSPHATE SYNTHASE (TARGET EFI-501951) FROM Methylococcus capsulatus
Descriptor: Geranyltranstransferase, PHOSPHATE ION
Authors:Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Poulter, C.D, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:2011-09-12
Release date:2011-10-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily.
Proc.Natl.Acad.Sci.USA, 110, 2013
8F8K
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BU of 8f8k by Molmil
The structure of Rv2173 from M. tuberculosis with IPP bound
Descriptor: (2E,6E)-farnesyl diphosphate synthase, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ACETATE ION, ...
Authors:Johnston, J.M, Allison, T.M, Titterington, J, Beasley, C.P.H.
Deposit date:2022-11-22
Release date:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
To be Published
8F8F
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BU of 8f8f by Molmil
The structure of Rv2173 from M. tuberculosis (APO form)
Descriptor: (2E,6E)-farnesyl diphosphate synthase, GLYCEROL, MAGNESIUM ION
Authors:Johnston, J.M, Allison, T.M, Titterington, J.
Deposit date:2022-11-22
Release date:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
To be Published
8F8L
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BU of 8f8l by Molmil
The structure of Rv2173 from M. tuberculosis with DMAP bound
Descriptor: (2E,6E)-farnesyl diphosphate synthase, CALCIUM ION, DIMETHYLALLYL DIPHOSPHATE, ...
Authors:Johnston, J.M, Allison, T.M, Titterington, J.
Deposit date:2022-11-22
Release date:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
To be Published
2VF6
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BU of 2vf6 by Molmil
Human FDPS synthase in complex with minodronate
Descriptor: (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID), FARNESYL PYROPHOSPHATE SYNTHETASE, MAGNESIUM ION
Authors:Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M.
Deposit date:2007-10-31
Release date:2007-11-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Fdps Synthase in Complex with Novel Inhibitor
To be Published

225158

数据于2024-09-18公开中

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