6G32

Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y

Summary for 6G32

Entry DOI	10.2210/pdb6g32/pdb
Descriptor	Geranylgeranyl pyrophosphate synthase, GLYCEROL (3 entities in total)
Functional Keywords	geranylgeranyl diphosphate synthase, mevalonate pathway, prenyltransferase, ggpps, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	213458.77
Authors	Lisnyansky, M.,Kapelushnik, N.,Ben-Bassat, A.,Marom, M.,Loewenstein, A.,Khananshvili, D.,Giladi, M.,Haitin, Y. (deposition date: 2018-03-24, release date: 2018-10-17, Last modification date: 2024-01-17)
Primary citation	Lisnyansky, M.,Kapelushnik, N.,Ben-Bassat, A.,Marom, M.,Loewenstein, A.,Khananshvili, D.,Giladi, M.,Haitin, Y. Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures. Mol. Pharmacol., 94:1391-1400, 2018 Cited by PubMed: 30275041 DOI: 10.1124/mol.118.113670 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.281 Å)

Structure validation