6G32

Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Geranylgeranyl pyrophosphate synthase	polymer	307	35484.4	6	UniProt (O95749) Pfam (PF00348) In PDB	Homo sapiens (Human)	GGPPSase,(2E,6E)-farnesyl diphosphate synthase,Dimethylallyltranstransferase,Farnesyl diphosphate synthase,Farnesyltranstransferase,Geranylgeranyl diphosphate synthase,Geranyltranstransferase
2	A, B, C, D, E...	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
3		water	water		18.0	1	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 300 (UniProt: O95749)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Gln 109	Pro 109	conflict
Tyr 188	Asp 188	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	212906.2
Non-Polymers*	Number of molecules	6
	Total formula weight	552.6
All*	Total formula weight	213458.8

*Water molecules are not included.