6N82

Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037

Summary for 6N82

Entry DOI	10.2210/pdb6n82/pdb
Descriptor	Farnesyl pyrophosphate synthase, GLYCEROL, [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid, ... (8 entities in total)
Functional Keywords	transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	44570.94
Authors	Park, J.,Schilling, M.A.,Berghuis, A.M. (deposition date: 2018-11-28, release date: 2019-11-06, Last modification date: 2023-10-11)
Primary citation	Feng, Y.,Park, J.,Li, S.G.,Boutin, R.,Viereck, P.,Schilling, M.A.,Berghuis, A.M.,Tsantrizos, Y.S. Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS). J.Med.Chem., 62:9691-9702, 2019 Cited by PubMed: 31577901 DOI: 10.1021/acs.jmedchem.9b01104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation