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2IUE
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BU of 2iue by Molmil
Pactolus I-domain: Functional Switching of the Rossmann Fold
Descriptor: INTEGRIN BETA-2-LIKE PROTEIN
Authors:Sen, M, Legge, G.B.
Deposit date:2006-06-02
Release date:2007-06-05
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Pactolus I-Domain: Functional Switching of the Rossmann Fold.
Proteins, 68, 2007
1M1X
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BU of 1m1x by Molmil
CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Xiong, J.-P, Stehle, T, Zhang, R, Joachimiak, A, Frech, M, Goodman, S.L, Arnaout, M.A.
Deposit date:2002-06-20
Release date:2002-08-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
5HDB
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BU of 5hdb by Molmil
Integrin alphaIIbbeta3 in complex with Ro-435054
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lin, F.Y.
Deposit date:2016-01-05
Release date:2016-02-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7012 Å)
Cite:beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece.
J.Biol.Chem., 291, 2016
2P26
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BU of 2p26 by Molmil
Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin beta-2
Authors:Shi, M, Foo, S.Y, Tan, S.M, Mitchell, E.P, Law, S.K.A, Lescar, J.
Deposit date:2007-03-06
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins
J.Biol.Chem., 282, 2007
7NXD
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BU of 7nxd by Molmil
Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N.
Deposit date:2021-03-18
Release date:2021-08-25
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
Sci Adv, 7, 2021
5FFG
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BU of 5ffg by Molmil
Crystal structure of integrin alpha V beta 6 head
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Dong, X, Springer, T.A.
Deposit date:2015-12-18
Release date:2017-01-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
7L8P
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BU of 7l8p by Molmil
Integrin alphaIIbbeta3 in complex with sibrafiban
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lin, F.-Y, Springer, T.A.
Deposit date:2020-12-31
Release date:2022-06-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.34995365 Å)
Cite:A general chemical principle for creating closure-stabilizing integrin inhibitors.
Cell, 185, 2022
7CEB
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BU of 7ceb by Molmil
Crystal structure of alpha6beta1 integrin headpiece
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-6, ...
Authors:Arimori, T, Takagi, J.
Deposit date:2020-06-22
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structural mechanism of laminin recognition by integrin.
Nat Commun, 12, 2021
4G1E
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BU of 4g1e by Molmil
Crystal structure of integrin alpha V beta 3 with coil-coiled tag.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Dong, X, Mi, L, Zhu, J, Wang, W, Luo, B, Springer, T.A.
Deposit date:2012-07-10
Release date:2012-12-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:AlphaV Beta3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
4G1M
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BU of 4g1m by Molmil
Re-refinement of alpha V beta 3 structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Springer, T.A, Mi, L, Zhu, J.
Deposit date:2012-07-10
Release date:2012-12-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Alpha V Beta 3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
3FCU
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BU of 3fcu by Molmil
Structure of headpiece of integrin aIIBb3 in open conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, CALCIUM ION, ...
Authors:Zhu, J, Luo, B.-H, Xiao, T, Zhang, C, Nishida, N, Springer, T.A.
Deposit date:2008-11-22
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
1U8C
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BU of 1u8c by Molmil
A novel adaptation of the integrin PSI domain revealed from its crystal structure
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Xiong, J.P, Stehle, T, Goodman, S.L, Arnaout, M.A.
Deposit date:2004-08-05
Release date:2004-12-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A novel adaptation of the integrin PSI domain revealed from its crystal structure.
J.Biol.Chem., 279, 2004
1JV2
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BU of 1jv2 by Molmil
CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Xiong, J.P, Stehle, T, Diefenbach, B, Zhang, R, Dunker, R, Scott, D, Joachimiak, A, Goodman, S.L, Arnaout, M.A.
Deposit date:2001-08-28
Release date:2001-10-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3.
Science, 294, 2001
9CKV
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BU of 9ckv by Molmil
Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Werther, R, Nguyen, A, Estrada Alamo, K.A, Wang, X, Campbell, M.G.
Deposit date:2024-07-09
Release date:2024-07-17
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:De Novo Design of Integrin alpha5beta1 Modulating Proteins for Regenerative Medicine
To Be Published
1TYE
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BU of 1tye by Molmil
Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, CALCIUM ION, ...
Authors:Xiao, T, Takagi, J, Coller, B.S, Wang, J.-H, Springer, T.A.
Deposit date:2004-07-07
Release date:2004-10-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
Nature, 432, 2004
4UM9
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BU of 4um9 by Molmil
Crystal structure of alpha V beta 6 with peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Dong, X, Springer, T.A.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
Nat.Struct.Mol.Biol., 21, 2014
1L5G
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BU of 1l5g by Molmil
CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Xiong, J.-P, Stehle, T, Zhang, R, Joachimiak, A, Frech, M, Goodman, S.L, Arnaout, M.A.
Deposit date:2002-03-06
Release date:2002-04-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
4UM8
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BU of 4um8 by Molmil
Crystal structure of alpha V beta 6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, ...
Authors:Dong, X, Springer, T.A.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.852 Å)
Cite:Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
Nat.Struct.Mol.Biol., 21, 2014
3FCS
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BU of 3fcs by Molmil
Structure of complete ectodomain of integrin aIIBb3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Zhu, J, Luo, B.-H, Xiao, T, Zhang, C, Nishida, N, Springer, T.A.
Deposit date:2008-11-22
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
6MK0
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BU of 6mk0 by Molmil
Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161
Descriptor: (2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1,8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:van Agthoven, J, Arnaout, M.A.
Deposit date:2018-09-24
Release date:2019-09-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
Acs Pharmacol Transl Sci, 2, 2019
4Z7O
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BU of 4z7o by Molmil
Integrin alphaIIbbeta3 in complex with AGDV peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lin, F.Y, Zhu, J, Springer, T.A.
Deposit date:2015-04-07
Release date:2016-01-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece.
J.Biol.Chem., 291, 2016
4Z7N
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BU of 4z7n by Molmil
Integrin alphaIIbbeta3 in complex with AGDV peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lin, F.-Y, Zhu, J, Springer, T.A.
Deposit date:2015-04-07
Release date:2015-12-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece.
J.Biol.Chem., 291, 2016
4Z7Q
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BU of 4z7q by Molmil
Integrin alphaIIbbeta3 in complex with AGDV-NH2 peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lin, F.-Y, Zhu, J, Springer, T.A.
Deposit date:2015-04-07
Release date:2015-12-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece.
J.Biol.Chem., 291, 2016
3NIF
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BU of 3nif by Molmil
The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethyl-7-piperazin-1-yl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ...
Authors:Zhu, J.H, Zhu, J.Q, Springer, T.A.
Deposit date:2010-06-15
Release date:2010-12-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Closed headpiece of integrin {alpha}IIb{beta}3 and its complex with an {alpha}IIb{beta}3-specific antagonist that does not induce opening.
Blood, 116, 2010
8IJ5
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BU of 8ij5 by Molmil
Cryo-EM structure of Integrin AVB3
Descriptor: Integrin alpha-V heavy chain, Integrin beta-3
Authors:Xi, Z, Cang, W, Yuanzhu, G.
Deposit date:2023-02-26
Release date:2024-02-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:cryo-EM Structure of Integrin AVB3
To Be Published

225158

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