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8VHQ
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BU of 8vhq by Molmil
Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and ATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHO
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BU of 8vho by Molmil
Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHR
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BU of 8vhr by Molmil
Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and GTP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHP
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BU of 8vhp by Molmil
Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to CDP and two molecules of ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.608 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHN
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BU of 8vhn by Molmil
Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to two ATP molecules
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
8VHU
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BU of 8vhu by Molmil
Crystal structure of dATP bound E. coli class Ia ribonucleotide reductase alpha construct fused with the C-terminal tail of E. coli class Ia beta subunit
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CHLORIDE ION, Fusion protein of Ribonucleoside-diphosphate reductase 1 subunits alpha and beta, ...
Authors:Funk, M.A, Zimanyi, C.M, Drennan, C.L.
Deposit date:2024-01-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.
Biochemistry, 2024
7RW6
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BU of 7rw6 by Molmil
BORF2-APOBEC3Bctd Complex
Descriptor: DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION
Authors:Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S.
Deposit date:2021-08-19
Release date:2022-04-27
Last modified:2022-05-04
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
Sci Adv, 8, 2022
7MDI
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BU of 7mdi by Molmil
Structure of the Neisseria gonorrhoeae ribonucleotide reductase in the inactive state
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Levitz, T.S, Drennan, C.L, Brignole, E.J.
Deposit date:2021-04-05
Release date:2022-01-05
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex.
J.Struct.Biol., 214, 2021
7AGJ
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BU of 7agj by Molmil
Ribonucleotide Reductase R1 protein from Aquifex aeolicus
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Rehling, D, Scaletti, E.R, Stenmark, P.
Deposit date:2020-09-22
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Biochemistry, 61, 2022
6W4X
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BU of 6w4x by Molmil
Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MU-OXO-DIIRON, ...
Authors:Kang, G, Taguchi, A, Stubbe, J, Drennan, C.
Deposit date:2020-03-11
Release date:2020-04-08
Last modified:2020-05-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex.
Science, 368, 2020
6LKM
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BU of 6lkm by Molmil
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide
Descriptor: 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ...
Authors:Miyahara, S, Chong, K.T, Suzuki, T.
Deposit date:2019-12-19
Release date:2020-12-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
6L7L
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BU of 6l7l by Molmil
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide
Descriptor: 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide, ACETATE ION, MAGNESIUM ION, ...
Authors:Miyahara, S, Chong, K.T, Suzuki, T.
Deposit date:2019-11-01
Release date:2020-11-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.171 Å)
Cite:TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
6L3R
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BU of 6l3r by Molmil
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide
Descriptor: 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide, ACETATE ION, MAGNESIUM ION, ...
Authors:Miyahara, S, Chong, K.T, Suzuki, T.
Deposit date:2019-10-15
Release date:2020-10-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
6MYX
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BU of 6myx by Molmil
EM structure of Bacillus subtilis ribonucleotide reductase inhibited double-helical filament of NrdE alpha subunit with dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase
Authors:Thomas, W.C, Bacik, J.P, Chen, J.Z, Ando, N.
Deposit date:2018-11-02
Release date:2019-06-19
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6MW3
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BU of 6mw3 by Molmil
EM structure of Bacillus subtilis ribonucleotide reductase inhibited filament composed of NrdE alpha subunit and NrdF beta subunit with dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase, Ribonucleoside-diphosphate reductase NrdF beta subunit
Authors:Thomas, W.C, Bacik, J.P, Kaelber, J.T, Ando, N.
Deposit date:2018-10-29
Release date:2019-06-19
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.65 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6MVE
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BU of 6mve by Molmil
Reduced X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N.
Deposit date:2018-10-25
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6MV9
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BU of 6mv9 by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase, ...
Authors:Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N.
Deposit date:2018-10-24
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6MT9
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BU of 6mt9 by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N.
Deposit date:2018-10-19
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6CGL
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BU of 6cgl by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound as-isolated (pH 4)
Descriptor: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Ribonucleoside-diphosphate reductase, SULFATE ION
Authors:Maggiolo, A.O, Boal, A.K.
Deposit date:2018-02-20
Release date:2018-05-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGN
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BU of 6cgn by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound (pH 7)
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ...
Authors:Maggiolo, A.O, Boal, A.K.
Deposit date:2018-02-20
Release date:2018-05-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGM
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BU of 6cgm by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit (nucleotide free)
Descriptor: 1,2-ETHANEDIOL, Ribonucleoside-diphosphate reductase
Authors:Maggiolo, A.O, Boal, A.K.
Deposit date:2018-02-20
Release date:2018-05-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6AUI
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BU of 6aui by Molmil
Human ribonucleotide reductase large subunit (alpha) with dATP and CDP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A.
Deposit date:2017-09-01
Release date:2018-04-18
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.
Elife, 7, 2018
5TUS
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BU of 5tus by Molmil
Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule
Descriptor: 2-hydroxy-N'-[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ...
Authors:Mohammed, F.A, Alam, I, Dealwis, C.G.
Deposit date:2016-11-07
Release date:2017-08-02
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5IM3
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BU of 5im3 by Molmil
Crystal structure of the class I ribonucleotide reductase from Pseudomonas aeruginosa in complex with dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase
Authors:Johansson, R, Logan, D.T.
Deposit date:2016-03-05
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones.
Structure, 24, 2016
5D1Y
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BU of 5d1y by Molmil
Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP
Descriptor: Ribonucleoside-diphosphate reductase large subunit
Authors:Ando, N, Li, H, Brignole, E.J, Thompson, S, McLaughlin, M.I, Page, J, Asturias, F, Stubbe, J, Drennan, C.L.
Deposit date:2015-08-04
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (9.005 Å)
Cite:Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.
Biochemistry, 55, 2016

 

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