8VHU

Crystal structure of dATP bound E. coli class Ia ribonucleotide reductase alpha construct fused with the C-terminal tail of E. coli class Ia beta subunit

Summary for 8VHU

Entry DOI	10.2210/pdb8vhu/pdb
Related	8VHN 8VHO 8VHP 8VHQ 8VHR
Descriptor	Fusion protein of Ribonucleoside-diphosphate reductase 1 subunits alpha and beta, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	ribonucleotide reductase, allosteric regulation, nucleotide binding, subunit interaction, oxidoreductase
Biological source	Escherichia coli K-12 More
Total number of polymer chains	2
Total formula weight	183754.97
Authors	Funk, M.A.,Zimanyi, C.M.,Drennan, C.L. (deposition date: 2024-01-02, release date: 2024-09-04)
Primary citation	Funk, M.A.,Zimanyi, C.M.,Andree, G.A.,Hamilos, A.E.,Drennan, C.L. How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase. Biochemistry, 2024 Cited by PubMed: 39164005 DOI: 10.1021/acs.biochem.4c00329 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation