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1QG1
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BU of 1qg1 by Molmil
GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH AN SHC-DERIVED PEPTIDE
Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR BINDING PROTEIN), PROTEIN (SHC-DERIVED PEPTIDE)
Authors:Ogura, K.
Deposit date:1999-04-19
Release date:1999-04-27
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.
J.Mol.Biol., 289, 1999
7NXE
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BU of 7nxe by Molmil
Structure of the Phospholipase C gamma 1 tSH2 domain in complex with a phosphorylated KSHV pK15 peptide
Descriptor: Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Protein K15
Authors:Ssebyatika, G, Krey, T.
Deposit date:2021-03-18
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Recruitment of phospholipase C gamma 1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.
Plos Pathog., 17, 2021
7SA7
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BU of 7sa7 by Molmil
Crystal structure of the apo SH2 domains of Syk
Descriptor: Tyrosine-protein kinase SYK
Authors:Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J.
Deposit date:2021-09-22
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein Sci., 30, 2021
6WAY
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BU of 6way by Molmil
C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide
Descriptor: Ras GTPase-activating protein 1, Rho GTPase-activating protein 35
Authors:Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J.
Deposit date:2020-03-26
Release date:2020-06-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain.
J.Biol.Chem., 295, 2020
3KFJ
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BU of 3kfj by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic
Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ...
Authors:Clements, J.H.
Deposit date:2009-10-27
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization.
J.Am.Chem.Soc., 131, 2009
3S8N
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BU of 3s8n by Molmil
Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ...
Authors:Clements, J.H, Stephen, F.M.
Deposit date:2011-05-29
Release date:2011-11-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area.
J.Am.Chem.Soc., 133, 2011
6HTF
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BU of 6htf by Molmil
Crystal structure of human Btk SH2 domain bound to rF10 repebody
Descriptor: Tyrosine-protein kinase BTK, rF10 repebody
Authors:Duarte, D.P, Pojer, F, Hantschel, O.
Deposit date:2018-10-04
Release date:2020-05-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Nat Commun, 11, 2020
5KAZ
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BU of 5kaz by Molmil
Human SH2D1B structure
Descriptor: SH2 domain-containing protein 1B, SULFATE ION
Authors:Taha, M, Nezerwa, E, Nam, H.-J.
Deposit date:2016-06-02
Release date:2017-04-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).
Protein Pept. Lett., 23, 2016
1HCT
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BU of 1hct by Molmil
NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
Descriptor: ACETYL-PYEEIE-OH, HUMAN SRC
Authors:Gampe Junior, R.T, Xu, R.X.
Deposit date:1994-09-02
Release date:1995-09-15
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
1HCS
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BU of 1hcs by Molmil
NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX
Descriptor: ACETYL-PYEEIE-OH, HUMAN SRC
Authors:Gampe Junior, R.T, Xu, R.X.
Deposit date:1994-09-02
Release date:1995-09-15
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
Biochemistry, 34, 1995
3WA4
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BU of 3wa4 by Molmil
Grb2 SH2 domain/CD28-derived peptide complex
Descriptor: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ...
Authors:Higo, K, Oda, M, Ito, N.
Deposit date:2013-04-23
Release date:2014-02-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28
Plos One, 8, 2013
2AOA
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BU of 2aoa by Molmil
Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain
Descriptor: 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Growth factor receptor-bound protein 2
Authors:Phan, J, Shi, Z.D, Burke, T.R, Waugh, D.S.
Deposit date:2005-08-12
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
J.Mol.Biol., 353, 2005
7CIO
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BU of 7cio by Molmil
Molecular interactions of cytoplasmic region of CTLA-4 with SH2 domains of PI3-kinase
Descriptor: Cytotoxic T-lymphocyte protein 4, Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Iiyama, M, Numoto, N, Ogawa, S, Kuroda, M, Morii, H, Abe, R, Ito, N, Oda, M.
Deposit date:2020-07-08
Release date:2020-12-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Mol.Immunol., 131, 2021
5JN0
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BU of 5jn0 by Molmil
CRK-II SH2 domain
Descriptor: CHLORIDE ION, CRK-II SH2 domain
Authors:Cho, J.-H.
Deposit date:2016-04-29
Release date:2017-08-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.677 Å)
Cite:CRK-II SH2 domain
To Be Published
6SM5
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BU of 6sm5 by Molmil
MbC/SHP1-C-SH2 complex
Descriptor: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6
Authors:Mann, G, Hantschel, O.
Deposit date:2019-08-21
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:MbC/SHP1-C-SH2 complex
To Be Published
4WWQ
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BU of 4wwq by Molmil
Apo structure of the Grb7 SH2 domain
Descriptor: Growth factor receptor-bound protein 7, MALONIC ACID
Authors:Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A.
Deposit date:2014-11-12
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
4X6S
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BU of 4x6s by Molmil
Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide
Descriptor: Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1
Authors:Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A.
Deposit date:2014-12-09
Release date:2015-09-23
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
2YSX
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BU of 2ysx by Molmil
Solution structure of the human SHIP SH2 domain
Descriptor: Signaling inositol polyphosphate phosphatase SHIP II
Authors:Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-04
Release date:2008-04-08
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the human SHIP SH2 domain
To be Published
5X94
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BU of 5x94 by Molmil
Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex
Descriptor: Cag pathogenicity island protein, Tyrosine-protein phosphatase non-receptor type 11
Authors:Senda, M, Senda, T.
Deposit date:2017-03-05
Release date:2017-09-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Cell Rep, 20, 2017
5MTN
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BU of 5mtn by Molmil
Monobody Mb(Lck_1) bound to Lck-Sh2
Descriptor: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck
Authors:Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-10
Release date:2017-04-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTJ
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BU of 5mtj by Molmil
Yes1-SH2 in complex with monobody Mb(Yes_1)
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ...
Authors:Sha, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-09
Release date:2017-04-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTM
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BU of 5mtm by Molmil
Monobody Mb(Lck_3) bound to Lck-SH2 domain
Descriptor: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION
Authors:Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
Deposit date:2017-01-10
Release date:2017-04-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
2L3T
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BU of 2l3t by Molmil
Solution structure of tandem SH2 domain from Spt6
Descriptor: Transcription elongation factor SPT6
Authors:Liu, J, Zhang, J, Wu, J, Shi, Y.
Deposit date:2010-09-22
Release date:2011-06-15
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain
To be Published
2L4K
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BU of 2l4k by Molmil
Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139
Descriptor: Growth factor receptor-bound protein 7, Receptor tyrosine-protein kinase erbB-2
Authors:Pias, S.C, Ivancic, M, Brescia, P.J, Johnson, D.L, Smith, D.E, Daly, R.J, Lyons, B.A.
Deposit date:2010-10-07
Release date:2010-11-17
Last modified:2012-10-03
Method:SOLUTION NMR
Cite:Water-Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139.
Protein Pept.Lett., 19, 2012
3MAZ
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BU of 3maz by Molmil
Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide
Descriptor: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1
Authors:Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S.
Deposit date:2010-03-24
Release date:2010-05-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Loops govern SH2 domain specificity by controlling access to binding pockets.
Sci.Signal., 3, 2010

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