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1RW2
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Three-dimensional structure of Ku80 CTD
分子名称: ATP-dependent DNA helicase II, 80 kDa subunit
著者Zhang, Z, Hu, W, Cano, L, Lee, T.D, Chen, D.J, Chen, Y.
登録日2003-12-15
公開日2003-12-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions.
STRUCTURE, 12, 2004
1Q2Z
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The 3D solution structure of the C-terminal region of Ku86
分子名称: ATP-dependent DNA helicase II, 80 kDa subunit
著者Harris, R, Esposito, D, Sankar, A, Maman, J.D, Hinks, J.A, Pearl, L.H, Driscoll, P.C.
登録日2003-07-28
公開日2004-01-13
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The 3D Solution Structure of the C-terminal Region of Ku86 (Ku86CTR)
J.Mol.Biol., 335, 2004
3ISM
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BU of 3ism by Molmil
Crystal structure of the EndoG/EndoGI complex: Mechanism of EndoG inhibition
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CG4930, CG8862, ...
著者Loll, B, Gebhardt, M, Wahle, E, Meinhart, A.
登録日2009-08-26
公開日2009-09-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition.
Nucleic Acids Res., 37, 2009
6ZHE
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BU of 6zhe by Molmil
Cryo-EM structure of DNA-PK dimer
分子名称: DNA (25-MER), DNA (26-MER), DNA (27-MER), ...
著者Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
登録日2020-06-23
公開日2020-10-21
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (7.24 Å)
主引用文献Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZH6
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Cryo-EM structure of DNA-PKcs:Ku80ct194
分子名称: DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5
著者Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
登録日2020-06-21
公開日2020-10-21
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.93 Å)
主引用文献Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZHA
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Cryo-EM structure of DNA-PK monomer
分子名称: DNA, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5, ...
著者Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
登録日2020-06-21
公開日2020-10-21
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.91 Å)
主引用文献Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
7K0Y
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Cryo-EM structure of activated-form DNA-PK (complex VI)
分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ...
著者Chen, X, Gellert, M, Yang, W.
登録日2020-09-06
公開日2021-01-06
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
7K1J
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CryoEM structure of inactivated-form DNA-PK (Complex III)
分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ...
著者Chen, X, Gellert, M, Yang, W.
登録日2020-09-07
公開日2021-01-06
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
7K1N
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CryoEM structure of inactivated-form DNA-PK (Complex V)
分子名称: DNA (5'-D(P*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ...
著者Chen, X, Gellert, M, Yang, W.
登録日2020-09-08
公開日2021-01-06
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
7K17
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Re-refined crystal structure of DNA-dependent protein kinase catalytic subunit complexed with Ku80 C-terminal helix
分子名称: DNA-dependent protein kinase catalytic subunit, X-ray repair cross-complementing protein 5
著者Chen, X, Gellert, M, Yang, W.
登録日2020-09-07
公開日2021-01-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (4.3 Å)
主引用文献Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
7K1K
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BU of 7k1k by Molmil
CryoEM structure of inactivated-form DNA-PK (Complex IV)
分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ...
著者Chen, X, Gellert, M, Yang, W.
登録日2020-09-07
公開日2021-01-06
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
7AXZ
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Ku70/80 complex apo form
分子名称: X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
著者Hnizda, A, Tesina, P, Novak, P, Blundell, T.L.
登録日2020-11-10
公開日2021-02-10
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献SAP domain forms a flexible part of DNA aperture in Ku70/80.
Febs J., 288, 2021
7LSY
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BU of 7lsy by Molmil
NHEJ Short-range synaptic complex
分子名称: DNA (26-MER), DNA (5'-D(P*CP*AP*AP*TP*GP*AP*AP*AP*CP*GP*GP*AP*AP*CP*AP*GP*TP*CP*AP*G)-3'), DNA (5'-D(P*GP*TP*TP*CP*TP*TP*AP*GP*TP*AP*TP*AP*TP*A)-3'), ...
著者He, Y, Chen, S.
登録日2021-02-18
公開日2021-04-14
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (8.4 Å)
主引用文献Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
7LT3
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BU of 7lt3 by Molmil
NHEJ Long-range synaptic complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (30-MER), DNA (31-MER), ...
著者He, Y, Chen, S.
登録日2021-02-18
公開日2021-04-14
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
7NFC
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BU of 7nfc by Molmil
Cryo-EM structure of NHEJ super-complex (dimer)
分子名称: DNA (27-MER), DNA (28-MER), DNA ligase 4, ...
著者Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
登録日2021-02-05
公開日2021-08-18
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
7NFE
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BU of 7nfe by Molmil
Cryo-EM structure of NHEJ super-complex (monomer)
分子名称: DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ...
著者Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
登録日2021-02-06
公開日2021-08-18
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (4.29 Å)
主引用文献Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
7SGL
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BU of 7sgl by Molmil
DNA-PK complex of DNA end processing
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, Hairpin_1, ...
著者Liu, L, Li, J, Chen, X, Yang, W, Gellert, M.
登録日2021-10-06
公開日2022-01-12
最終更新日2022-01-19
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7SU3
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BU of 7su3 by Molmil
CryoEM structure of DNA-PK complex VII
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ...
著者Chen, X, Liu, L, Gellert, M, Yang, W.
登録日2021-11-16
公開日2022-01-12
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
7SUD
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BU of 7sud by Molmil
CryoEM structure of DNA-PK complex VIII
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, MAGNESIUM ION, ...
著者Chen, X, Liu, L, Gellert, M, Yang, W.
登録日2021-11-16
公開日2022-01-12
最終更新日2022-01-19
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
8AG5
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Vaccinia C16 protein bound to Ku70/Ku80
分子名称: Ku70-Xrcc6, Protein C10, X-ray repair cross-complementing protein 5
著者Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O.
登録日2022-07-19
公開日2022-11-09
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.
Nat Commun, 13, 2022
8AG4
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Vaccinia C16 protein bound to Ku70/Ku80
分子名称: Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
著者Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O.
登録日2022-07-19
公開日2022-11-09
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.46 Å)
主引用文献Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.
Nat Commun, 13, 2022
7Z88
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DNA-PK in the intermediate state
分子名称: (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ...
著者Liang, S, Blundell, T.L.
登録日2022-03-16
公開日2023-01-18
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.33 Å)
主引用文献Human DNA-dependent protein kinase activation mechanism.
Nat.Struct.Mol.Biol., 30, 2023
7Z87
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DNA-PK in the active state
分子名称: (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ...
著者Liang, S, Blundell, T.L.
登録日2022-03-16
公開日2023-01-18
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Human DNA-dependent protein kinase activation mechanism.
Nat.Struct.Mol.Biol., 30, 2023
7ZT6
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Cryo-EM structure of Ku 70/80 bound to inositol hexakisphosphate
分子名称: INOSITOL HEXAKISPHOSPHATE, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
著者Kefala Stavridi, A, Chaplin, A.K, Blundell, T.L.
登録日2022-05-09
公開日2023-05-17
最終更新日2023-12-06
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
7ZVT
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CryoEM structure of Ku heterodimer bound to DNA
分子名称: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ...
著者Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K.
登録日2022-05-17
公開日2023-05-24
最終更新日2023-12-06
実験手法ELECTRON MICROSCOPY (2.74 Å)
主引用文献Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023

 

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