6IHG
 
 | | N terminal domain of Mycobacterium avium complex Lon protease | | 分子名称: | Lon protease | | 著者 | Chen, X.Y, Zhang, S.J, Bi, F.K, Guo, C.Y, Yao, H.W, Lin, D.H. | | 登録日 | 2018-09-29 | | 公開日 | 2019-08-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | | 主引用文献 | Crystal structure of the N domain of Lon protease from Mycobacterium avium complex.
Protein Sci., 28, 2019
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3M65
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3LJC
 | | Crystal structure of Lon N-terminal domain. | | 分子名称: | ATP-dependent protease La | | 著者 | Li, M, Gustchina, A, Dauter, Z, Wlodawer, A. | | 登録日 | 2010-01-26 | | 公開日 | 2010-07-21 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of the N-terminal fragment of Escherichia coli Lon protease
Acta Crystallogr.,Sect.D, 66, 2010
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1ZBO
 | | X-Ray Crystal Structure of Protein BPP1347 from Bordetella parapertussis. Northeast Structural Genomics Consortium Target BoR27. | | 分子名称: | hypothetical protein BPP1347 | | 著者 | Forouhar, F, Yong, W, Conover, K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2005-04-08 | | 公開日 | 2005-04-19 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal Structure of the Hypothetical Protein BPP1347 from Bordetella parapertussis, Northeast Structural Genomics Target BoR27.
To be Published
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2ANE
 | | Crystal structure of N-terminal domain of E.Coli Lon Protease | | 分子名称: | ATP-dependent protease La | | 著者 | Li, M, Rasulova, F, Melnikov, E.E, Rotanova, T.V, Gustchina, A, Maurizi, M.R, Wlodawer, A. | | 登録日 | 2005-08-11 | | 公開日 | 2005-11-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Crystal structure of the N-terminal domain of E. coli Lon protease.
Protein Sci., 14, 2005
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7CAY
 | | Crystal Structure of Lon N-terminal domain protein from Xanthomonas campestris | | 分子名称: | ATP-dependent protease | | 著者 | Singh, R, Sharma, B, Deshmukh, S, Kumar, A, Makde, R.D. | | 登録日 | 2020-06-10 | | 公開日 | 2020-10-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of XCC3289 from Xanthomonas campestris: homology with the N-terminal substrate-binding domain of Lon peptidase.
Acta Crystallogr.,Sect.F, 76, 2020
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7CRA
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7CR9
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6XK9
 | | Cereblon in complex with DDB1, CC-90009, and GSPT1 | | 分子名称: | 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | | 著者 | Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P. | | 登録日 | 2020-06-25 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.64 Å) | | 主引用文献 | CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Blood, 137, 2021
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5HXB
 | | Cereblon in complex with DDB1, CC-885, and GSPT1 | | 分子名称: | 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | | 著者 | Chamberlain, P.P, Matyskiela, M, Pagarigan, B. | | 登録日 | 2016-01-30 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature, 535, 2016
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4TZ4
 | | Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide | | 分子名称: | DNA damage-binding protein 1, Protein cereblon, S-Lenalidomide, ... | | 著者 | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B, Riley, M. | | 登録日 | 2014-07-09 | | 公開日 | 2014-08-06 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
To Be Published
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5V3O
 | | Cereblon in complex with DDB1 and CC-220 | | 分子名称: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... | | 著者 | Matyskiela, M, Pagarigan, B, Chamberlain, P. | | 登録日 | 2017-03-07 | | 公開日 | 2017-05-03 | | 最終更新日 | 2018-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J. Med. Chem., 61, 2018
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4CI3
 | | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide | | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ... | | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | | 登録日 | 2013-12-05 | | 公開日 | 2014-07-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
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4CI1
 | | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide | | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ... | | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | | 登録日 | 2013-12-05 | | 公開日 | 2014-07-16 | | 最終更新日 | 2019-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
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4CI2
 | | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide | | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ... | | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | | 登録日 | 2013-12-05 | | 公開日 | 2014-07-16 | | 最終更新日 | 2019-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
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8OIZ
 | | Crystal structure of human CRBN-DDB1 in complex with Pomalidomide | | 分子名称: | 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... | | 著者 | Le Bihan, Y.-V, Cabry, M.P, van Montfort, R.L.M. | | 登録日 | 2023-03-23 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity.
Chembiochem, 24, 2023
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8OJH
 | | Crystal structure of human CRBN-DDB1 in complex with compound 4 | | 分子名称: | 1,2-ETHANEDIOL, 4-azanyl-2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-7-methoxy-isoindole-1,3-dione, DNA damage-binding protein 1, ... | | 著者 | Cabry, M.P, Le Bihan, Y.-V, van Montfort, R.L.M. | | 登録日 | 2023-03-24 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity.
Chembiochem, 24, 2023
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8CVP
 | | Cereblon-DDB1 in the Apo form | | 分子名称: | DNA damage-binding protein 1, Protein cereblon, ZINC ION | | 著者 | Watson, E.R, Lander, G.C. | | 登録日 | 2022-05-18 | | 公開日 | 2022-07-20 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
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8D7V
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8D7X
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8D81
 | | Cereblon~DDB1 bound to Pomalidomide | | 分子名称: | DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... | | 著者 | Watson, E.R, Lander, G.C. | | 登録日 | 2022-06-07 | | 公開日 | 2022-07-20 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
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8D7U
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8D7W
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8D7Y
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7OXO
 | | human LonP1, R-state, incubated in AMPPCP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | | 著者 | Abrahams, J.P, Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T. | | 登録日 | 2021-06-22 | | 公開日 | 2021-12-22 | | 最終更新日 | 2022-11-09 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Catalytic cycling of human mitochondrial Lon protease.
Structure, 30, 2022
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