6XK9

Cereblon in complex with DDB1, CC-90009, and GSPT1

Summary for 6XK9

• Entry DOI: 10.2210/pdb6xk9/pdb
• Descriptor: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, DNA damage-binding protein 1, Protein cereblon, ... (5 entities in total)
• Functional Keywords: ddb1, molecular glue, degradation, cc-90009, acute myeloid leukemia, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 392434.18

Authors

Clayton, T.L.,Tran, E.T.,Zhu, J.,Pagarigan, B.E.,Matyskiela, M.E.,Chamberlain, P.P. (deposition date: 2020-06-25, release date: 2020-12-02, Last modification date: 2023-10-18)

• Primary citation: Surka, C.,Jin, L.,Mbong, N.,Lu, C.C.,Jang, I.S.,Rychak, E.,Mendy, D.,Clayton, T.,Tindall, E.,Hsu, C.,Fontanillo, C.,Tran, E.,Contreras, A.,Ng, S.W.K.,Matyskiela, M.,Wang, K.,Chamberlain, P.,Cathers, B.,Carmichael, J.,Hansen, J.,Wang, J.C.Y.,Minden, M.D.,Fan, J.,Pierce, D.W.,Pourdehnad, M.,Rolfe, M.,Lopez-Girona, A.,Dick, J.E.,Lu, G.; CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.; Blood, 137:661-677, 2021; PubMed: 33197925; DOI: 10.1182/blood.2020008676

Experimental method

X-RAY DIFFRACTION (3.64 Å)