6XK9

Cereblon in complex with DDB1, CC-90009, and GSPT1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (X, A)	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A	polymer	199	21995.8	2	UniProt (P15170) Pfam (PF03144) Pfam (PF22594)	Homo sapiens (Human)	eRF3a,G1 to S phase transition protein 1 homolog
2	B, E (Y, B)	DNA damage-binding protein 1	polymer	1140	127097.5	2	UniProt (Q16531) Pfam (PF10433) Pfam (PF23726) Pfam (PF03178)	Homo sapiens (Human)	DDB p127 subunit,DNA damage-binding protein a,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,XPE-binding factor,Xeroderma pigmentosum group E-complementing protein
3	C, F (Z, C)	Protein cereblon	polymer	406	46596.6	2	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (Human)
4	G, I (Z, C)	2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide	non-polymer		461.8	2	Chemie (V4M)
5	H, J (Z, C)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

X, A: 437 - 633 (UniProt: P15170)

PDB	External Database	Details
Gly 435	-	expression tag
Ser 436	-	expression tag

Z, C: 40 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Gly 37	-	expression tag
Ser 38	-	expression tag
Met 39	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	391379.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1054.5
All*	Total formula weight	392434.2

*Water molecules are not included.